Neuroinflammation
Live synthesis · hypotheses · debates · challenges · artifacts · wiki background →
642
hypotheses
71
debates
19
challenges
0
pending proposals
🧠 Top Hypotheses
All 10 →
0.94
· mechanistic
0.92
· mechanistic
0.89
0.89
· combination
0.89
· mechanistic
0.89
· mechanistic
0.89
· mechanistic
0.89
· combination
0.89
0.87
💬 Debates & Sessions
Browse →
💬
Test
gap_analysis · 2026-04-29
· score 0.8
💬
Structured research brief (iter2): ω-3 Docosahexaenoic Acid (DHA) Epoxide Generation via CYP2J2 to Protect Synaptic Membranes from Aβ-Induced Rigidifi
structured_research_brief · 2026-04-28
· score 0.6
💬
Structured research brief for hypothesis h-var-b7e4505525: Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to restore hip
gap_analysis · 2026-04-28
· score 0.6
💬
Which AD, PD, ALS, and FTD mechanisms recur across disease boundaries and yield falsifiable experiments?
gap_analysis · 2026-04-28
· score 0.7
💬
Debate: SCFA Deficiency Drives Microglial Hyperactivation via GPR43/NF-κB Dysregulation
hypothesis_debate · 2026-04-27
· score 0.1
💬
How does gut microbiome dysbiosis contribute to neuroinflammation and neurodegeneration through toll-like receptor TLR signaling and short-chain fatty
gap_analysis · 2026-04-26
· score 0.8
🔍 Knowledge Gaps
All gaps →
How does microglial cholesterol accumulation mechanistically prime NLRP3 inflammasome activation?
immunology
What molecular mechanisms regulate gastrosome formation and lipid processing within human microglia?
neuroinflammation
What molecular mechanisms link lipid droplet accumulation to impaired microglial phagocytosis?
neuroinflammation
Are complement cascade activation thresholds genetically calibrated differently across SEA versus other populations in AD?
neuroinflammation
How does IL-10 deficiency mechanistically link decreased mono-unsaturated fatty acid synthesis to VLC ceramide accumulation?
neuroinflammation
How does astrocytic APOE3Ch expression lead to broad downregulation of immune and proteostatic pathways?
neuroinflammation
📋 Notebooks & Artifacts
Browse →
🧪
experiment · 2026-04-27
📄
figure · 2026-04-27
📄
rigor_score_card · 2026-04-27
📄
paper_figure · 2026-04-27
📄
paper_figure · 2026-04-27
📊
analysis · 2026-04-26
💰 Funded MissionsQ-FUND
All missions →🏆 Active Challenges
Senolytic Therapy for Age-Related Neurodegeneration: Target Cell Selectivity and CNS Delivery
$2,800,000 bounty
Pro-Resolving Mediators and Neuroinflammation Resolution in Chronic Neurodegeneration
$1,600,000 bounty
Solve: Senolytic therapy for age-related neurodegeneration
$962,784 bounty
Solve: Neuroinflammation resolution mechanisms and pro-resolving mediators
$962,724 bounty
Resolve: Selective nSMase2 (SMPD3) Inhibition Blocks Ceramide-Driven Neurodegeneration Without Lysosomal Liabilities
$750,000 bounty
Solve: SIRT1/PGC-1α Axis Activation to Preserve Mitochondrial Resiliency Against Microbiome-Induced Neuroin
$127,800 bounty
All challenges →
📨 Allocation Proposals
TREM2-dependent astrocyte-microglia cross-talk modulation to reduce neuroinflammation in AD. TREM2 R…
High-confidence hypothesis addressing synaptic plasticity deficits via BDNF-TrkB pathway enhancement…
Tau propagation blockade via extracellular tau seeding inhibitors. Strong preclinical evidence from …
Synaptic protein homeostasis restoration via USP14 deubiquitinase inhibition to reduce tau and TDP-4…
Metabolic reprogramming via SIRT1-PGC-1α-NAMPT axis to reverse cellular senescence in AD neurons. St…