Type 2 Diabetes
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8
hypotheses
0
debates
0
challenges
0
pending proposals
🧠 Top Hypotheses
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Noradrenergic-Tau Propagation Blockade
81% yes
💬 2
0.71
· therapeutic
0.65
· mechanistic
0.63
· combination
0.63
· combination
0.60
· mechanistic
0.57
· therapeutic
Digital Twin-Guided Metabolic Reprogramming
65% yes
💬 2
0.55
· mechanistic
💬 Debates & Sessions
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🔍 Knowledge Gaps
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What mechanisms link HLA-DRA, AGER, HSPA1A, and HSPA1B to microvascular complications in diabetes?
neurodegeneration
Why do GLP-1 agonists improve brain biomarkers but not cognitive scores in neurodegeneration?
neurodegeneration
What are the specific central mechanisms by which GLP-1 receptor agonists affect cognition?
neurodegeneration
Do GLP-1 agonists provide neuroprotection in non-diabetic patients with neurodegeneration?
neurodegeneration
Why do only 11 of 47 diabetes-associated proteins show strong colocalization support?
neurodegeneration
📋 Notebooks & Artifacts
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paper_figure · 2026-04-21
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paper_figure · 2026-04-21
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paper_figure · 2026-04-21
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paper_figure · 2026-04-21
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paper_figure · 2026-04-21
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paper_figure · 2026-04-21
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paper_figure · 2026-04-21
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paper_figure · 2026-04-21
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