The study identifies these four proteins as associated with most diabetic microvascular complications, but the mechanistic pathways connecting these proteins to vascular damage are not explained. Understanding these mechanisms is critical since microvascular complications affect the nervous system through diabetic neuropathy. Gap type: unexplained_observation Source paper: Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteome-wide Mendelian randomization and colocalization analyses. (2023, Cell Rep Med, PMID:37652020)
Landscape Summary: What mechanisms link HLA-DRA, AGER, HSPA1A, and HSPA1B to microvascular complications in diabetes? is a 0.79 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.
Colonna, Sevlever, et al. (TREM2 biology)
What mechanisms link HLA-DRA, AGER, HSPA1A, and HSPA1B to microvascular complications in diabetes? — INVOKE-2 (completed)
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