Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Aβ Oligomers: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| tau hyperphosphorylation | triggers | mechanism | 0.90 |
| microglia | activates | cell_type | 0.90 |
| tau missorting | causes | mechanism | 0.90 |
| synapse loss | causes | phenotype | 0.90 |
| Hippocampal Neuronal Damage | causes | phenotype | 0.85 |
| tau hyperphosphorylation | causes | mechanism | 0.70 |
| SPP1 | causes | gene | 0.70 |
| DNMT1 activity | inhibits | protein | 0.70 |
| C1q/C3/CR3 upregulation | causes | mechanism | 0.70 |
| Perivascular macrophages | activates | cell_type | 0.70 |
| SPP1 upregulation | causes | process | 0.70 |
| complement cascade | activates | pathway | 0.70 |
| HDAC2 phosphorylation at S421/S423 | causes | mechanism | 0.70 |
| microglial activation | activates | process | 0.70 |
| calcium dysregulation | causes | mechanism | 0.70 |
| tau propagation | causes | process | 0.70 |
| EDN1 | activates | protein | 0.70 |
| pericyte oxidative stress | causes | process | 0.70 |
| KCNQ2/3 channels | regulates | protein | 0.70 |
| theta_oscillations | disrupts | phenotype | 0.70 |
| gamma oscillations | inhibits | phenotype | 0.70 |
| tau-Fyn complex formation | activates | mechanism | 0.70 |
| KCNQ2/3 channels | inhibits | protein | 0.70 |
| PV interneuron function | associated_with | phenotype | 0.70 |
| CD36 | activates | protein | 0.50 |
| YAP/TAZ nuclear translocation | causes | process | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Closed-loop focused ultrasound targeting CA1 PV interneurons | 0.729 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
Scientific analyses that reference this entity
Alzheimer's disease | 2026-04-28 | 7 hypotheses Top: 0.700
neurodegeneration | 2026-04-25 | 7 hypotheses Top: 0.740
neurodegeneration | 2026-04-25 | 6 hypotheses Top: 0.720
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.629
neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.643
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667] | Zhang D, Zhang W, Ming C, Gao X, Yuan H, | Neuron | 2024 | 0 |
| The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117] | Balusu S, De Strooper B | Acta neuropathologica | 2024 | 0 |
| Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890] | Burillo J, Marqués P, Jiménez B, Gonzále | Cells | 2021 | 0 |
| Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169] | ["Oakley, Holly", "Cole, Sarah L", "Loga | The Journal of neuroscience : | 2006 | 0 |
| The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773] | ["Hardy, John", "Selkoe, Dennis J"] | Science (New York, N.Y.) | 2002 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.72 · 2026-04-28
closed · Rounds: 4 · Score: 0.65 · 2026-04-25
closed · Rounds: 4 · Score: 0.68 · 2026-04-25
closed · Rounds: 4 · Score: 0.68 · 2026-04-22
closed · Rounds: 4 · Score: 0.67 · 2026-04-22
closed · Rounds: 4 · Score: 0.68 · 2026-04-21
closed · Rounds: 4 · Score: 0.70 · 2026-04-21
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
Hypotheses and analyses mentioning Aβ Oligomers in their description or question text
No additional research found