gene

CD36

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD36: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

570Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

CD36 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with ALS, Als, Alzheimer. Connected to 248 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CD36
Aliases	Comprehensive review of CD36 scavenger receptor
Chromosome	7q21.11
Protein Type	Gene
Function	is a multifunctional class B scavenger receptor encoded by the CD36 gene located on chromosome 7q21.
Molecular Weight	88 kDa
Amino Acids	472 aa
Exons	15
Pathways	Amyloid, Cholesterol, Epigenetic, Ferroptosis, Lipid Metabolism
GeneCards	CD36
Human Protein Atlas	CD36
Associated Diseases	ALS, Alzheimer, Atherosclerosis, Cancer, Inflammation, Myocardial Infarction
Interactions	ABCA1, ABCG1, AGING, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections	570 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

cd36

gene · 2666 words

→

CD36 Protein (Cluster of Differentiation 36)

protein · 914 words

→

Pathway Diagram

flowchart TD
    AmyloidB["Amyloid beta
Plaques"] -->|"activates"| CD36["CD36
Scavenger Receptor"]
    CD36 -->|"activates"| PINK1["PINK1
Mitochondrial Kinase"]
    CD36 -->|"promotes"| Pericytes["Pericytes
BBB Support"]
    CD36 -->|"activates"| Inflammation["Systemic
Inflammation"]
    CD36 -->|"activates"| Neuroinflammation["Neuroinflammation
CNS Immune Response"]
    CD36 -->|"regulates"| MS["Multiple
Sclerosis"]
    CD36 -->|"interacts_with"| Alzheimer["Alzheimer's
Disease"]
    CD36 -->|"inhibits"| ALS_Protection["ALS
Neuroprotection"]
    CD36 -->|"associated_with"| Stroke["Ischemic
Stroke"]
    
    Neuroinflammation -->|"contributes_to"| Alzheimer
    Neuroinflammation -->|"worsens"| MS
    Inflammation -->|"promotes"| Neuroinflammation
    PINK1 -->|"maintains"| MitoFunction["Mitochondrial
Function"]
    Pericytes -->|"maintains"| BBB["Blood-Brain
Barrier Integrity"]
    
    MitoFunction -->|"protects_against"| Neurodegeneration["Neuronal
Death"]
    BBB -->|"prevents"| Neuroinflammation
    
    style CD36 fill:#006494
    style PINK1 fill:#4a1a6b
    style Pericytes fill:#1b5e20
    style BBB fill:#1b5e20
    style MitoFunction fill:#1b5e20
    style ALS_Protection fill:#1b5e20
    style AmyloidB fill:#ef5350
    style Inflammation fill:#ef5350
    style Neuroinflammation fill:#ef5350
    style Alzheimer fill:#5d4400
    style MS fill:#5d4400
    style Stroke fill:#5d4400
    style Neurodegeneration fill:#5d4400

Outgoing (413)

Target	Relation	Type	Str
Lipid Metabolism	associated_with	process	0.85
autophagy flux	inhibits	process	0.85
Phagocytosis	involved_in	process	0.85
LIPID METABOLISM	involved_in	entity	0.85
Inflammation	activates	disease	0.85
Tumor Immune Cell Activity	regulates	process	0.80
Ovarian Cancer	therapeutic_target	disease	0.80
sepsis-induced liver injury	promotes	disease	0.80
Ovarian Cancer	biomarker_for	disease	0.80
Neuroinflammation	activates	disease	0.75
Inflammation	regulates	disease	0.75
Tumor	inhibits	disease	0.75
LC3	modulates	protein	0.75
pericyte	regulates	cell_type	0.70
PINK1	interacts_with	protein	0.70
amyloid-beta uptake	regulates	mechanism	0.70
ATP	inhibits	gene	0.70
ASTROCYTES	inhibits	gene	0.70
blood-brain barrier	participates_in	pathway	0.70
INFLAMMATION	activates	gene	0.70
pericyte	activates	cell_type	0.70
PINK1	activates	protein	0.70
Pi3K/Akt	inhibits	pathway	0.70
oxidized lipid uptake	regulates	mechanism	0.70
Lipid Metabolism	activates	pathway	0.70
Lipid Metabolism	inhibits	pathway	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
Autophagy	inhibits	pathway	0.70
NEUROINFLAMMATION	activates	gene	0.70
microglia	expressed_in	cell_type	0.70
AKT	inhibits	gene	0.70
Phagocytosis	regulates	pathway	0.70
Alzheimer	therapeutic_target	disease	0.65
Diabetes	regulates	disease	0.65
Ms	regulates	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Stroke	activates	disease	0.65
Als	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Carcinoma	activates	disease	0.65
Cirrhosis	activates	disease	0.65
Cancer	inhibits	disease	0.65
Atherosclerosis	associated_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Als	inhibits	disease	0.65
Hepatitis	inhibits	disease	0.65
Als	therapeutic_target	disease	0.65

Incoming (157)

Source	Relation	Type	Str
TFEB	regulates	gene	0.85
PPARΑ	regulates	gene	0.80
PPARΑ	upregulates	gene	0.80
AMYLOID	associated_with	disease	0.80
SPP1	upregulates	gene	0.75
Amyloid β	activates	protein	0.70
PI3K	inhibits	gene	0.70
AMPK	inhibits	gene	0.70
APOA1	regulates	entity	0.60
CD163	phosphorylates	entity	0.60
APP	causes	gene	0.60
AKT2	regulates	gene	0.60
ACSL4	biomarker_for	gene	0.60
CD163	biomarker_for	gene	0.60
CD206	biomarker_for	gene	0.60
ACC	expressed_in	gene	0.60
ERK	therapeutic_target	gene	0.60
INFLAMMATION	regulates	gene	0.60
PI3K	activates	gene	0.60
MITOCHONDRIA	activates	gene	0.60
ROS	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
NF-ΚB	inhibits	gene	0.60
INSULIN RESISTANCE	inhibits	gene	0.60
PCK1	interacts_with	gene	0.60
GENES	interacts_with	gene	0.60
CANCER	interacts_with	gene	0.60
AMPK	phosphorylates	entity	0.60
AMYLOID	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
AGING	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
SYNAPSE	activates	gene	0.60
GASTRODIN	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
RNA	activates	gene	0.60
LC3B	activates	gene	0.60
TNF-Α	activates	gene	0.60
AKT	phosphorylates	gene	0.60
APP	inhibits	gene	0.60
PI3K	phosphorylates	gene	0.60
AKT	activates	gene	0.60
APP	expressed_in	gene	0.60
APP	associated_with	gene	0.60
AKT	expressed_in	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macr	0.535	neurodegeneration	How do perivascular cells specifically r

Mentioning Analyses (2)

Scientific analyses that reference this entity

Can P16INK4A expression reliably distinguish harmful from beneficial senescent m

neurodegeneration | 2026-04-11 | 0 hypotheses

How do perivascular cells specifically recognize and respond to amyloid-β to upr

neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.618

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The abstract indicates SPP1 upregulation occurs in perivascular macrophages and

closed · Rounds: 4 · Score: 0.67 · 2026-04-22

The debate proposed P16INK4A-guided targeting but the Skeptic noted microglia ex

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning CD36 in their description or question text

No additional research found