gene

CD36

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD36: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

570Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

CD36 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with ALS, Als, Alzheimer. Connected to 248 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CD36
Aliases	Comprehensive review of CD36 scavenger receptor
Chromosome	7q21.11
Protein Type	Gene
Function	is a multifunctional class B scavenger receptor encoded by the CD36 gene located on chromosome 7q21.
Molecular Weight	88 kDa
Amino Acids	472 aa
Exons	15
Pathways	Amyloid, Cholesterol, Epigenetic, Ferroptosis, Lipid Metabolism
GeneCards	CD36
Human Protein Atlas	CD36
Associated Diseases	ALS, Alzheimer, Atherosclerosis, Cancer, Inflammation, Myocardial Infarction
Interactions	ABCA1, ABCG1, AGING, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections	570 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

cd36

gene · 2666 words

→

CD36 Protein (Cluster of Differentiation 36)

protein · 914 words

→

Pathway Diagram

flowchart TD
    AmyloidB["Amyloid beta
Plaques"] -->|"activates"| CD36["CD36
Scavenger Receptor"]
    CD36 -->|"activates"| PINK1["PINK1
Mitochondrial Kinase"]
    CD36 -->|"promotes"| Pericytes["Pericytes
BBB Support"]
    CD36 -->|"activates"| Inflammation["Systemic
Inflammation"]
    CD36 -->|"activates"| Neuroinflammation["Neuroinflammation
CNS Immune Response"]
    CD36 -->|"regulates"| MS["Multiple
Sclerosis"]
    CD36 -->|"interacts_with"| Alzheimer["Alzheimer's
Disease"]
    CD36 -->|"inhibits"| ALS_Protection["ALS
Neuroprotection"]
    CD36 -->|"associated_with"| Stroke["Ischemic
Stroke"]
    
    Neuroinflammation -->|"contributes_to"| Alzheimer
    Neuroinflammation -->|"worsens"| MS
    Inflammation -->|"promotes"| Neuroinflammation
    PINK1 -->|"maintains"| MitoFunction["Mitochondrial
Function"]
    Pericytes -->|"maintains"| BBB["Blood-Brain
Barrier Integrity"]
    
    MitoFunction -->|"protects_against"| Neurodegeneration["Neuronal
Death"]
    BBB -->|"prevents"| Neuroinflammation
    
    style CD36 fill:#006494
    style PINK1 fill:#4a1a6b
    style Pericytes fill:#1b5e20
    style BBB fill:#1b5e20
    style MitoFunction fill:#1b5e20
    style ALS_Protection fill:#1b5e20
    style AmyloidB fill:#ef5350
    style Inflammation fill:#ef5350
    style Neuroinflammation fill:#ef5350
    style Alzheimer fill:#5d4400
    style MS fill:#5d4400
    style Stroke fill:#5d4400
    style Neurodegeneration fill:#5d4400

Outgoing (413)

Target	Relation	Type	Str
Phagocytosis	involved_in	process	0.85
Lipid Metabolism	associated_with	process	0.85
LIPID METABOLISM	involved_in	entity	0.85
autophagy flux	inhibits	process	0.85
Inflammation	activates	disease	0.85
Tumor Immune Cell Activity	regulates	process	0.80
sepsis-induced liver injury	promotes	disease	0.80
Ovarian Cancer	biomarker_for	disease	0.80
Ovarian Cancer	therapeutic_target	disease	0.80
LC3	modulates	protein	0.75
Tumor	inhibits	disease	0.75
Inflammation	regulates	disease	0.75
Neuroinflammation	activates	disease	0.75
ATP	inhibits	gene	0.70
ASTROCYTES	inhibits	gene	0.70
microglia	expressed_in	cell_type	0.70
ubiquitin-proteasome	participates_in	pathway	0.70
PINK1	interacts_with	protein	0.70
Pi3K/Akt	inhibits	pathway	0.70
pericyte	regulates	cell_type	0.70
Phagocytosis	regulates	pathway	0.70
PINK1	activates	protein	0.70
pericyte	activates	cell_type	0.70
oxidized lipid uptake	regulates	mechanism	0.70
blood-brain barrier	participates_in	pathway	0.70
amyloid-beta uptake	regulates	mechanism	0.70
NEUROINFLAMMATION	activates	gene	0.70
Lipid Metabolism	activates	pathway	0.70
INFLAMMATION	activates	gene	0.70
AKT	inhibits	gene	0.70
Lipid Metabolism	inhibits	pathway	0.70
Autophagy	inhibits	pathway	0.70
Alzheimer	interacts_with	disease	0.65
Cardiac	regulates	disease	0.65
Als	interacts_with	disease	0.65
Ferroptosis	inhibits	disease	0.65
Tumor	interacts_with	disease	0.65
Atherosclerosis	regulates	disease	0.65
Atherosclerosis	therapeutic_target	disease	0.65
Macular Degeneration	activates	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Tumor	regulates	disease	0.65
Cancer	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Fibrosis	regulates	disease	0.65
Cancer	interacts_with	disease	0.65
ALS	activates	disease	0.65
Ms	interacts_with	disease	0.65
Als	biomarker_for	disease	0.65

Incoming (157)

Source	Relation	Type	Str
TFEB	regulates	gene	0.85
PPARΑ	regulates	gene	0.80
PPARΑ	upregulates	gene	0.80
AMYLOID	associated_with	disease	0.80
SPP1	upregulates	gene	0.75
AMPK	inhibits	gene	0.70
PI3K	inhibits	gene	0.70
Amyloid β	activates	protein	0.70
TLR2	associated_with	gene	0.60
RAGE	associated_with	gene	0.60
SIRT6	activates	gene	0.60
HNRNPA2B1	regulates	gene	0.60
IDE	activates	gene	0.60
P38	regulates	gene	0.60
CD14	associated_with	gene	0.60
CD163	activates	gene	0.60
FAS	expressed_in	gene	0.60
UBQLN1	regulates	gene	0.60
DRP1	regulates	gene	0.60
FUNDC1	regulates	gene	0.60
HK2	inhibits	gene	0.60
MYC	inhibits	gene	0.60
TLR4	associated_with	gene	0.60
SIRT6	causes	gene	0.60
CD68	activates	gene	0.60
PLIN2	activates	gene	0.60
NR1H3	activates	gene	0.60
CMKLR1	interacts_with	gene	0.60
NRF2	activates	gene	0.60
TNF	activates	gene	0.60
PI3K	activates	gene	0.60
FYN	inhibits	gene	0.60
JNK	inhibits	gene	0.60
ARG1	inhibits	gene	0.60
ABCG1	inhibits	gene	0.60
TNF	inhibits	gene	0.60
ATG5	inhibits	gene	0.60
P62	inhibits	gene	0.60
LPL	interacts_with	gene	0.60
PPARGC1A	interacts_with	gene	0.60
APOA1	regulates	entity	0.60
CD163	phosphorylates	entity	0.60
CX3CR1	activates	gene	0.60
LPL	regulates	gene	0.60
APP	therapeutic_target	gene	0.60
TREM2	associated_with	gene	0.60
CD68	inhibits	gene	0.60
RAGE	inhibits	gene	0.60
SQSTM1	activates	gene	0.60
TFEB	activates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macr	0.535	neurodegeneration	How do perivascular cells specifically r

Mentioning Analyses (2)

Scientific analyses that reference this entity

Can P16INK4A expression reliably distinguish harmful from beneficial senescent m

neurodegeneration | 2026-04-11 | 0 hypotheses

How do perivascular cells specifically recognize and respond to amyloid-β to upr

neurodegeneration | 2026-04-06 | 7 hypotheses Top: 0.618

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The abstract indicates SPP1 upregulation occurs in perivascular macrophages and

closed · Rounds: 4 · Score: 0.67 · 2026-04-22

The debate proposed P16INK4A-guided targeting but the Skeptic noted microglia ex

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning CD36 in their description or question text

No additional research found