CD36

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD36: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

CD36 is a gene implicated in neurodegeneration research. Key relationships include: activates, inhibits, regulates. Associated with ALS, Als, Alzheimer. Connected to 248 entities in the SciDEX knowledge graph.

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flowchart TD
    AmyloidB["Amyloid beta<br/>Plaques"] --|"activates"|--> CD36["CD36<br/>Scavenger Receptor"]
    CD36 --|"activates"|--> PINK1["PINK1<br/>Mitochondrial Kinase"]
    CD36 --|"promotes"|--> Pericytes["Pericytes<br/>BBB Support"]
    CD36 --|"activates"|--> Inflammation["Systemic<br/>Inflammation"]
    CD36 --|"activates"|--> Neuroinflammation["Neuroinflammation<br/>CNS Immune Response"]
    CD36 --|"regulates"|--> MS["Multiple<br/>Sclerosis"]
    CD36 --|"interacts_with"|--> Alzheimer["Alzheimer's<br/>Disease"]
    CD36 --|"inhibits"|--> ALS_Protection["ALS<br/>Neuroprotection"]
    CD36 --|"associated_with"|--> Stroke["Ischemic<br/>Stroke"]
    
    Neuroinflammation --|"contributes_to"|--> Alzheimer
    Neuroinflammation --|"worsens"|--> MS
    Inflammation --|"promotes"|--> Neuroinflammation
    PINK1 --|"maintains"|--> MitoFunction["Mitochondrial<br/>Function"]
    Pericytes --|"maintains"|--> BBB["Blood-Brain<br/>Barrier Integrity"]
    
    MitoFunction --|"protects_against"|--> Neurodegeneration["Neuronal<br/>Death"]
    BBB --|"prevents"|--> Neuroinflammation
    
    style CD36 fill:#006494
    style PINK1 fill:#4a1a6b
    style Pericytes fill:#1b5e20
    style BBB fill:#1b5e20
    style MitoFunction fill:#1b5e20
    style ALS_Protection fill:#1b5e20
    style AmyloidB fill:#ef5350
    style Inflammation fill:#ef5350
    style Neuroinflammation fill:#ef5350
    style Alzheimer fill:#5d4400
    style MS fill:#5d4400
    style Stroke fill:#5d4400
    style Neurodegeneration fill:#5d4400