concept

SYNAPSE LOSS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SYNAPSE LOSS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

48Connections

0Hypotheses

1Analyses

5Outgoing

43Incoming

0Experiments

1Debates

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💡 Concept Info

Name	SYNAPSE LOSS

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Complement-Mediated Synapse Loss

mechanism · 3185 words

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Pathway Diagram

graph TD
    SYNAPSE_LOSS["SYNAPSE LOSS"]
    SYNAPSE_LOSS -->|"contributes to"| Alzheimer_s_Disease["Alzheimer's Disease"]
    SYNAPSE_LOSS -->|"correlates_with"| Cognitive_Decline["Cognitive Decline"]
    C1Q["C1Q"] -->|"mediates"| SYNAPSE_LOSS
    Microglia["Microglia"] -->|"mediates"| SYNAPSE_LOSS
    Complement["Complement"] -->|"mediates"| SYNAPSE_LOSS
    GADD45G["GADD45G"] -->|"causes"| SYNAPSE_LOSS
    Inhibition_of_C1Q["Inhibition of C1Q"] -.protects against.-> SYNAPSE_LOSS
    Inhibition_of_C3["Inhibition of C3"] -.protects against.-> SYNAPSE_LOSS
    Alzheimer_s_Disease -->|"causes"| SYNAPSE_LOSS
    NPTX2["NPTX2"] -.protects against.-> SYNAPSE_LOSS

Outgoing (5)

Target	Relation	Type	Str
Alzheimer's Disease	contributes_to	disease	0.95
Cognitive Decline	associated_with	phenotype	0.90
Neuroplasticity	associated_with	process	0.88
Cognitive Decline	correlates_with	phenotype	0.85
COVID-19 Neuropathologies	biomarker_for	disease	0.80

Incoming (43)

Source	Relation	Type	Str
C1Q	mediates	protein	0.95
Microglia	mediates	cell_type	0.95
Complement	mediates	pathway	0.95
GADD45G	causes	gene	0.92
Beta-Amyloid Oligomers	causes	compound	0.92
CR3	involved_in	receptor	0.90
Complement-Blocking Antibody	protects_against	drug	0.90
Alzheimer's Disease	causes	disease	0.90
MICROGLIA	mediates	cell_type	0.90
Brain-Penetrant Complement-Blocking Antibody	protects_against	drug	0.90
Amyloid_Beta	causes	compound	0.90
Microglia	promotes	cell_type	0.90
C1Q	associated_with	protein	0.90
NEUROINFLAMMATION	causes	process	0.90
Inhibition of C1Q	protects_against	mechanism	0.90
Inhibition of C3	protects_against	mechanism	0.90
β-amyloid Oligomers	causes	compound	0.90
C1Q	promotes	protein	0.90
Classical Complement Cascade	drives	pathway	0.90
Microglia	causes	cell_type	0.90
NPTX2	protects_against	protein	0.90
Minocycline	protects_against	drug	0.90
brain-penetrant recombinant antibody	decreases	compound	0.90
Classical Complement Cascade	contributes_to	pathway	0.88
Neuroinflammation	causes	process	0.85
ALZHEIMER'S DISEASE	associated_with	disease	0.85
Complement System	contributes_to	pathway	0.85
TAU	implicated_in	entity	0.85
Amyloid-Beta	causes	protein	0.85
Dark Microglia	causes	phenotype	0.85
C3	involved_in	protein	0.85
Integrated Stress Response Inhibition	associated_with	process	0.85
C3	promotes	protein	0.85
amyloid-β	causes	protein	0.80
Astrocytes	contributes_to	cell_type	0.80
Lipid Synthesis Inhibition	associated_with	process	0.80
Microglia	contributes_to	cell_type	0.80
complement activation	causes	process	0.70
tau pathology	causes	process	0.70
BMAL1	protects_against	gene	0.70
microglia	promotes	cell_type	0.70
DEPRESSION	causes	gene	0.70
C1q blockade	inhibits	drug	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Synaptic pruning by microglia in neurodegeneration

neurodegeneration | 2026-04-02 | 7 hypotheses Top: 0.720

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What is the role of microglial synaptic pruning in Alzheimer's disease and other

active · Rounds: 4 · Score: 0.68 · 2026-04-22