pathway

complement cascade

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about complement cascade: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

261Connections

4Hypotheses

3Analyses

23Outgoing

50Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info

Name	complement cascade
Key Genes/Proteins	C3, AQP4-antibody, C4, GFAP
Related Diseases	neurodegeneration, Alzheimer's disease
Linked Hypotheses	11 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    complement_cascade["complement cascade"] -->|"mediates"| GRANULOCYTE_INFILTRATION["GRANULOCYTE INFILTRATION"]
    style GRANULOCYTE_INFILTRATION fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    complement_cascade["complement cascade"] -->|"causes"| ASTROCYTE["ASTROCYTE"]
    style ASTROCYTE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    complement_cascade["complement cascade"] -->|"causes"| OLIGODENDROCYTE["OLIGODENDROCYTE"]
    style OLIGODENDROCYTE fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    complement_cascade["complement cascade"] -->|"active in"| microglia["microglia"]
    style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    complement_cascade["complement cascade"] -->|"active in"| astrocytes["astrocytes"]
    style astrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    complement_cascade["complement cascade"] -->|"active in"| oligodendrocytes["oligodendrocytes"]
    style oligodendrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    complement_cascade["complement cascade"] -->|"active in"| neurons["neurons"]
    style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    AQP4["AQP4"] -->|"activates"| complement_cascade["complement cascade"]
    style AQP4 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Alzheimer_s_disease["Alzheimer's disease"] -->|"involves"| complement_cascade["complement cascade"]
    style Alzheimer_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    C3["C3"] -->|"participates in"| complement_cascade["complement cascade"]
    style C3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    neurodegeneration["neurodegeneration"] -->|"involves"| complement_cascade["complement cascade"]
    style neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    multiple_sclerosis["multiple sclerosis"] -->|"involves"| complement_cascade["complement cascade"]
    style multiple_sclerosis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    style complement_cascade fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (77)

Target	Relation	Type	Str
microglial phagocytosis	mediates	process	0.90
microglia	active_in	cell_type	0.90
neural stem cells	active_in	cell_type	0.90
demyelination	mediates	process	0.85
phagocytosis	mediates	process	0.80
astrocytes	active_in	cell_type	0.80
oligodendrocytes	active_in	cell_type	0.80
neurons	active_in	cell_type	0.80
unfolded protein response	crosstalk_with	pathway	0.80
endothelial cells	active_in	cell_type	0.80
hippocampus	modulates	brain_region	0.80
synaptic plasticity	crosstalk_with	pathway	0.70
cortex	active_in	brain_region	0.70
spinal cord	active_in	brain_region	0.60
striatum	active_in	brain_region	0.60
synaptic pruning	mediates	process	0.60
interneurons	active_in	cell_type	0.60
pyroptosis	crosstalk_with	pathway	0.60
macrophages	active_in	cell_type	0.60
oxidative stress response	crosstalk_with	pathway	0.60
hippocampus	active_in	brain_region	0.60
blood-brain barrier	active_in	brain_region	0.60
T cells	active_in	cell_type	0.60

Incoming (184)

Source	Relation	Type	Str
C3	involved_in	gene	0.95
C3	participates_in	gene	0.90
neurodegeneration	involves	disease	0.90
AQP4-antibody	activates	protein	0.90
eculizumab	inhibits	drug	0.90
Alzheimer's disease	involves	disease	0.90
C4	participates_in	gene	0.85
GFAP	participates_in	gene	0.85
microglia	active_in	cell_type	0.85
astrocytes	active_in	cell_type	0.85
DAM microglia	active_in	cell_type	0.85
neuroinflammation	involves	disease	0.80
CR3	participates_in	gene	0.80
multiple sclerosis	involves	disease	0.80
C1Q	initiates	gene	0.80
APOE	participates_in	gene	0.75
AQP4	participates_in	gene	0.70
TREM2	participates_in	gene	0.70
C1QA	participates_in	gene	0.70
CD47	participates_in	gene	0.70
C1QB	participates_in	gene	0.70
TET2	participates_in	gene	0.65
TNF	participates_in	gene	0.65
neurons	active_in	cell_type	0.65
CX3CR1	participates_in	gene	0.60
depression	involves	disease	0.60
NLRP3	participates_in	gene	0.60
SREBF2	participates_in	gene	0.60
GLP1R	participates_in	gene	0.60
STX17	participates_in	gene	0.60
STING1	participates_in	gene	0.60
ULK1	participates_in	gene	0.60
TFEB	participates_in	gene	0.60
C1Q	participates_in	gene	0.60
TP53	participates_in	gene	0.60
MTOR	participates_in	gene	0.60
FOXO1	participates_in	gene	0.60
PLIN2	participates_in	gene	0.60
BECN1	participates_in	gene	0.60
SIRT3	participates_in	gene	0.60
SIRT1	participates_in	gene	0.60
SQSTM1	participates_in	gene	0.60
LC3	participates_in	gene	0.60
CD4	participates_in	gene	0.60
C5	participates_in	gene	0.60
PLIN3	participates_in	gene	0.60
PRKAA2	participates_in	gene	0.60
HTRA2	participates_in	gene	0.60
NFE2L2	participates_in	gene	0.60
RPTOR	participates_in	gene	0.60

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SASP-Mediated Complement Cascade Amplification	0.703	neurodegeneration	Senolytic therapy for age-related neurod
Timed Senolytic Therapy Eliminates p16^Ink4a/p21^Cip1-Senesc	0.587	neuroinflammation	What molecular mechanisms drive the tran
Senescent Cell ASM-Complement Cascade Intervention	0.552	neurodegeneration	Lipid raft composition changes in synapt
Complement Cascade Activation Bridges Microglial OxPC Sensin	0.452	neuroinflammation	What molecular mechanisms enable microgl

Mentioning Analyses (3)

Scientific analyses that reference this entity

Immune atlas neuroinflammation analysis in neurodegeneration

Neuroinflammation | 2026-04-03 | 1 hypotheses Top: 0.522

Immune atlas neuroinflammation analysis in neurodegeneration

Neuroinflammation | 2026-04-02 | 0 hypotheses

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.703

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Complement, Inflammasome, and Microglial Crosstalk in Glaucoma: From Neurodegene [PMID:41900887]	Chen TY, Wu N, Sun X	Life (Basel)	2026	1
Systemic Neurodegeneration and Brain Aging: Multi-Omics Disintegration, Proteost [PMID:40868276]	Voicu V, Toader C, Șerban M, Covache-Bus	Biomedicines	2025	1
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614]	Han QQ, Shen SY, Liang LF, Chen XR, Yu J	Brain Behav Immun	2024	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
Microglia regulation of synaptic plasticity and learning and memory. [PMID:34472455]	Cornell J, Salinas S, Huang HY, Zhou M	Neural Regen Res	2022	1
Complement and microglia mediate early synapse loss in Alzheimer mouse models. [PMID:27033548]	Hong S, Beja-Glasser VF, Nfonoyim BM, Fr	Science	2016	1
Panacis Quinquefolii Radix Polysaccharides Alleviate Depressive-Like Behaviors i [PMID:41914021]	Xie M, Feng L, Li R, Li M, Shen L, Zhang	CNS neuroscience & therapeutic	2026	0
Vaccine-induced antibodies can limit Salmonella infection in the absence of comp [PMID:41738756]	Perez-Toledo M, Aksu-Istil K, Marcial-Ju	mBio	2026	0
The Immuno-Glial Connectome in Alzheimer's Disease: Integrating Central and Peri [PMID:41569436]	Gopalakrishna PK, Che Mohd Nassir CMN, A	Cellular and molecular neurobi	2026	0
Messengers of coagulopathy: complement-carrying extracellular vesicles in SARS-C [PMID:41766448]	Taxiarchis A, Pruner I	Current opinion in hematology	2026	0
Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721]	Aranda-Abreu GE, Rojas-Durán F, Hernánde	Neurology international	2026	0
The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkins [PMID:39964974]	Dai L, Wang J, Meng L, Zhang X, Xiao T,	PLoS biology	2025	0
PDE4 inhibition alleviates HMGB1/C1q/C3-mediated excessive phagocytic pruning of [PMID:39947489]	Zhao Q, Zeng C, Luo F, Xian Z, Wen H, Tu	Brain, behavior, and immunity	2025	0
Acid sphingomyelinase activity suggests a new antipsychotic pharmaco-treatment s [PMID:39825014]	Chestnykh D, Mühle C, Schumacher F, Kali	Mol Psychiatry	2025	0
Large-scale Plasma Proteomic Profiling Unveils Novel Diagnostic Biomarkers and P [PMID:40166037]	Cruchaga C, Heo G, Thomas A, Wang E, Oh	Res Sq	2025	0
Reduction of sphingomyelinase activity associated with progranulin deficiency an [PMID:40633679]	Boyle NR, Fox SN, Tadepalli AS, Seyfried	Neurobiol Dis	2025	0
Botulinum Neurotoxin Induces Neurotoxic Microglia Mediated by Exogenous Inflamma [PMID:38342616]	Ambrin G, Kang YJ, Van Do K, Lee C, Sing	Advanced science (Weinheim, Ba	2024	0
Development of Injectable Thermosensitive Nanocomposite Hydrogel for Ratiometric [PMID:38456789]	["Zhu J", "Wei R", "Hu G", "Wang H", "Wa	Small (Weinheim an der Bergstr	2024	0
The Role of Complement Dysregulation in Glaucoma. [PMID:38396986]	["Hoppe C", "Gregory-Ksander M"]	International journal of molec	2024	0
Retracted: Ginsenoside Rg1 Ameliorates Acute Renal Ischemia/Reperfusion Injury v [PMID:38234567]	["Longevity O"]	Oxidative medicine and cellula	2024	0

complement cascade

Understanding Entity Pages

Wiki Pages (20)

Novel Therapy Index

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Microglial Cells — Cell Type Hierarchy

Astrocyte Reactivity Mechanism

Excitotoxicity in Neurodegeneration

Novartis Alzheimer's Disease Phase 2 Trial (NCT07094516)

Neuroinflammation in Parkinson's Disease

Amyloid-beta Cellular Uptake Pathway

CR1 Gene — Complement Component 1q Receptor

Prion Strain Diversity and Selective Vulnerability

Alzheimer's Disease Synaptic Repair and Neuroprotection Companies

Neuroinflammation Microglia

Multifocal Motor Neuropathy (MMN)

microglial-synaptic-pruning-dysregulation

Complement System in Neurodegeneration

Demyelination

Neuromyelitis Optica Spectrum Disorder (NMOSD)

Complement-Mediated Synapse Loss

Neuroinflammation in Alzheimer's Disease

ALS Regional Onset and Spread: Network-Level Staging Model

Pathway Diagram

Outgoing (77)

Incoming (184)

Targeting Hypotheses (4)

Mentioning Analyses (3)

Immune atlas neuroinflammation analysis in neurodegeneration

Immune atlas neuroinflammation analysis in neurodegeneration

Senolytic therapy for age-related neurodegeneration

Related Papers (20)