Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Aβ accumulation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| tau pathology | causes | mechanism | 0.90 |
| retinal neurodegeneration | promotes | process | 0.70 |
| proteasome function | inhibits | process | 0.70 |
| lysosomal function | inhibits | process | 0.70 |
| complement C1q activation | activates | pathway | 0.50 |
| proteasome dysfunction | causes | process | 0.50 |
| lysosomal dysfunction | causes | process | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Sulforaphane | inhibits | compound | 0.90 |
| 36917314 | defers | paper | 0.90 |
| 41313780 | suppressed | paper | 0.90 |
| lecanemab | therapeutic_target_for | drug | 0.90 |
| donanemab | therapeutic_target_for | drug | 0.90 |
| MT-CO3 | precedes | protein | 0.70 |
| APP | activates | protein | 0.70 |
| 40 Hz gamma entrainment | inhibits | phenotype | 0.70 |
| enhanced autophagy | prevents | process | 0.70 |
| MT-CO1 | precedes | protein | 0.70 |
| Indoles | protects_against | process | 0.70 |
| autophagy impairment | causes | process | 0.70 |
| PI3K | inhibits | gene | 0.70 |
| 21456963 | could relate to | paper | 0.60 |
| CCR2+ monocytes | causes | cell_type | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
Alzheimer's disease | 2026-04-28 | 7 hypotheses Top: 0.725
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.629
neurodegeneration | 2026-04-16 | 2 hypotheses Top: 0.380
neurodegeneration | 2026-04-12 | 1 hypotheses Top: 0.566
neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.605
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.72 · 2026-04-28
closed · Rounds: 4 · Score: 0.62 · 2026-04-21
closed · Rounds: 4 · Score: 0.70 · 2026-04-21
closed · Rounds: 4 · Score: 0.70 · 2026-04-21
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
closed · Rounds: 5 · Score: 0.67 · 2026-04-12
closed · Rounds: 4 · Score: 0.76 · 2026-04-12
closed · Rounds: 4 · Score: 0.78 · 2026-04-12
closed · Rounds: 4 · Score: 0.50 · 2026-04-11
Hypotheses and analyses mentioning Aβ accumulation in their description or question text
No additional research found