concept

SULFORAPHANE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SULFORAPHANE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

88Connections

1Hypotheses

1Analyses

50Outgoing

27Incoming

1Experiments

1Debates

No summary available yet.

View on Wiki →

No AI portrait yet

💡 Concept Info

Name	SULFORAPHANE
Key Genes/Proteins	AKT, AQP4, BDNF, CREB, ERK, HDAC2
Related Diseases	ALZHEIMER, ALZHEIMER'S DISEASE, ATHEROSCLEROSIS, AUTOPHAGY, CHOLESTEROL

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Sulforaphane and Nrf2 Activation for Neuroprotection

therapeutic · 4477 words

→

Pathway Diagram

graph TD
    SULFORAPHANE["SULFORAPHANE"]
    SULFORAPHANE -->|"activates"| TFEB["TFEB"]
    SULFORAPHANE -->|"activates"| lipophagy["lipophagy"]
    SULFORAPHANE -->|"activates"| AMPK["AMPK"]
    SULFORAPHANE -->|"mediates"| TFEB_Nuclear_Translocation["TFEB Nuclear Translocation"]
    SULFORAPHANE -->|"treats"| Oxidative_Stress["Oxidative Stress"]
    SULFORAPHANE -->|"contributes to"| LC3["LC3"]
    SULFORAPHANE -->|"inhibits"| Neuroinflammation["Neuroinflammation"]
    SULFORAPHANE -->|"suppresses"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]

Outgoing (61)

Target	Relation	Type	Str
h-5050522d	targeted_by	hypothesis	1.00
TFEB	activates	protein	0.95
AMPK	activates	protein	0.90
lipophagy	activates	pathway	0.90
Aβ accumulation	inhibits	process	0.90
Tau hyperphosphorylation	inhibits	process	0.90
TFEB Nuclear Translocation	mediates	mechanism	0.88
GSK3B	activates	gene	0.85
Oxidative Stress	treats	disease	0.85
LC3	contributes_to	protein	0.80
Neuroinflammation	inhibits	process	0.80
KL	modulates	gene	0.75
OXIDATIVE STRESS	suppresses	process	0.75
NRF2	activates	protein	0.70
ASTROCYTES	activates	cell_type	0.70
ASTROCYTES	protects_against	cell_type	0.70
NRF2	activates	protein	0.70
cerebral ischemia/reperfusion injury	treats	disease	0.70
BDNF	regulates	gene	0.65
BDNF	associated_with	gene	0.65
BDNF	phosphorylates	gene	0.65
ISCHEMIA	activates	disease	0.65
AQP4	protects_against	gene	0.65
AQP4	regulates	gene	0.65
TAU	inhibits	protein	0.65
OXIDATIVE STRESS	activates	phenotype	0.65
BDNF	activates	gene	0.65
HDAC2	inhibits	gene	0.65
BDNF	expressed_in	gene	0.55
ROS	associated_with	phenotype	0.50
ASTROCYTES	associated_with	cell_type	0.50
ASTROCYTE	associated_with	cell_type	0.50
NRF2	associated_with	gene	0.50
MAPK	associated_with	gene	0.50
AUTOPHAGY	associated_with	phenotype	0.50
KEAP1	associated_with	gene	0.50
HMOX1	associated_with	gene	0.50
LAMP1	associated_with	gene	0.50
MTOR	associated_with	gene	0.50
TFEB	associated_with	gene	0.50
HO-1	associated_with	gene	0.50
AQP4	associated_with	gene	0.45
TREM2	associated_with	gene	0.45
ISCHEMIA	associated_with	disease	0.45
CURCUMIN	associated_with	drug	0.45
RESVERATROL	associated_with	drug	0.45
ALZHEIMER	associated_with	disease	0.45
STING	associated_with	gene	0.45
RAPAMYCIN	associated_with	drug	0.45
QUERCETIN	associated_with	drug	0.45

Incoming (27)

Source	Relation	Type	Str
h-5050522d	targets	hypothesis	1.00
41894075	modulates	paper	0.90
41894075	suppresses	paper	0.90
41894075	mitigates	paper	0.90
41894075	attenuates	paper	0.90
41894075	preserves	paper	0.90
41894075	inhibits	paper	0.90
41894075	activates	paper	0.90
41894075	improves	paper	0.90
27143001	activates	paper	0.60
41894075	represents potential for	paper	0.60
OXIDATIVE STRESS	associated_with	phenotype	0.50
ATHEROSCLEROSIS	associated_with	disease	0.50
RESVERATROL	associated_with	drug	0.45
SIRT1	associated_with	gene	0.45
STING	associated_with	gene	0.45
BDNF	associated_with	gene	0.45
ALZHEIMER	associated_with	disease	0.45
NEURONS	associated_with	cell_type	0.45
AKT	associated_with	gene	0.45
CREB	associated_with	gene	0.45
ERK	associated_with	gene	0.45
HDAC2	associated_with	gene	0.45
N-ACETYLCYSTEINE	associated_with	drug	0.45
CURCUMIN	associated_with	drug	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.45
HMGB1	associated_with	gene	0.45

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Sequential Iron Chelation (Deferoxamine) and GPX4 Restoratio	0.838	neurodegeneration	Can ferroptosis inhibitors prevent BBB d

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does RGS6 upregulation or D2 autoreceptor modulation prevent neurodegeneration i

neurodegeneration | 2026-04-17 | 7 hypotheses Top: 0.559

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Sequential DFO + Sulforaphane Prevents Iron-Ferroptosis Cascade in Rat	in_vivo	post-cardiac-arrest neurodegen	0.768	0.72	Sprague-Dawley rat asphyxial c	abandoned	$48,000

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810]	["Chen Kai", "Li Fuyao", "Zhang Shuwen",	Journal of neuroinflammation	2025
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554]	Marogianni C, Sokratous M, Dardiotis E,	International journal of molec	2020
Multiple Sclerosis Pathology. [PMID:29358320]	Lassmann H	Cold Spring Harbor perspective	2018

Debates (1)

Multi-agent debates referencing this entity

While RGS6 deficiency causes Parkinson's-like pathology, whether enhancing RGS6

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning SULFORAPHANE in their description or question text

No additional research found