protein

PI3K

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7192Connections

1Hypotheses

4Analyses

50Outgoing

50Incoming

Summary

A protein referenced in 2 knowledge graph relationships. Key connections: activates AKT (protein); SYK_kinase (protein) activates.

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🔬 Protein Info

Gene Symbol	PI3K (family), PIK3CA, PIK3CB, etc.
Full Name	Phosphoinositide 3-Kinase
Aliases	PI3K, Phosphatidylinositol 3-kinase, VPS34
Chromosome	Various (multiple genes across classes)
Protein Type	Kinase
Function	Class I PI3Ks: Generate PIP3 from PIP2 - Activated by receptor tyrosine kinases (RTKs), G-protein coupled receptors (GPCRs), and small GTPases (Ras) - p110α (PIK3CA): growth factor signaling
Pathways	AUTOPHAGY, LIPID METABOLISM, OXIDATIVE_STRESS, PI3K/AKT, PI3K_AKT_MTOR_pathway
NCBI Gene ID	Multiple (e.g., PIK3CA: 5290, PIK3CB: 5293)
Protein	Phosphoinositide 3-kinase
Strategy	Development Stage
mTOR inhibitors (rapamycin)	Preclinical/Clinical
Akt activators	Preclinical
GSK3β inhibitors	Clinical trials
PI3K isoform-selective	Preclinical
PTEN	Opposing enzyme
Associated Diseases	AD, ALS, AMI, ARM, Aging
Known Drugs/Compounds	CAMP, RAPAMYCIN, QUERCETIN, RESVERATROL, Rehmannioside_A, LY294002
Interactions	LOX, MTOR, AKT, SQSTM1, EIF4EBP1, P62
KG Connections	5220 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    subgraph Pathology["Pathology"]
        PI3K["PI3K"] -->|"associated with"| CANCER["CANCER"]
    end
    subgraph Signaling["Signaling"]
        PI3K["PI3K"] -->|"activates"| AKT["AKT"]
        PI3K["PI3K"] -.->|"inhibits"| MTOR["MTOR"]
        PI3K["PI3K"] -.->|"inhibits"| AKT_1["AKT"]
        PI3K["PI3K"] -.->|"inhibits"| GENES["GENES"]
        PI3K["PI3K"] -.->|"inhibits"| Als["Als"]
        PI3K["PI3K"] -.->|"inhibits"| Autophagy["Autophagy"]
        PI3K["PI3K"] -.->|"inhibits"| Mtor["Mtor"]
        PI3K["PI3K"] -->|"activates"| Cancer["Cancer"]
        PTEN["PTEN"] -.->|"inhibits"| PI3K["PI3K"]
        PTEN_2["PTEN"] -->|"activates"| PI3K["PI3K"]
        AKT_4["AKT"] -->|"activates"| PI3K["PI3K"]
        MTOR_5["MTOR"] -->|"activates"| PI3K["PI3K"]
        TNF["TNF"] -->|"activates"| PI3K["PI3K"]
    end
    subgraph Therapeutic["Therapeutic"]
        PTEN_3["PTEN"] -->|"therapeutic target"| PI3K["PI3K"]
    end
    style PI3K fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
    style CANCER fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AKT fill:#006494,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style MTOR fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AKT_1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style GENES fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Autophagy fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Mtor fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style PTEN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style PTEN_2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style PTEN_3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style AKT_4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style MTOR_5 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style TNF fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0

Outgoing (3667)

Target	Relation	Type	Str
AKT	activates	protein	1.00
MTOR	inhibits	gene	1.00
AKT	inhibits	gene	1.00
MTOR	activates	gene	1.00
AKT	regulates	gene	1.00
MTOR	associated_with	gene	1.00
AKT	associated_with	gene	1.00
AKT	therapeutic_target	gene	1.00
NRF2	activates	gene	1.00
EGFR	activates	gene	1.00
MTOR	regulates	gene	1.00
MTOR	therapeutic_target	gene	1.00
TP53	therapeutic_target	gene	1.00
LC3	activates	gene	1.00
AKT	expressed_in	gene	1.00
OVERVIEW	therapeutic_target	gene	1.00
TP53	associated_with	gene	1.00
EGFR	therapeutic_target	gene	1.00
AKT	contributes_to	gene	1.00
JNK	activates	gene	1.00
CANCER	associated_with	disease	1.00
GENES	inhibits	gene	1.00
Als	inhibits	disease	1.00
Autophagy	inhibits	pathway	1.00
Mtor	inhibits	pathway	1.00
Cancer	activates	disease	1.00
Als	activates	disease	1.00
Tumor	activates	disease	1.00
Oxidative Phosphorylation	activates	pathway	1.00
Glycolysis	activates	pathway	1.00
Mtor	activates	pathway	1.00
GENES	activates	gene	1.00
AMPK	activates	gene	1.00
GENES	regulates	gene	1.00
Inflammation	activates	disease	1.00
Neurodegeneration	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Aging	therapeutic_target	disease	1.00
Autophagy	therapeutic_target	pathway	1.00
Wnt	associated_with	pathway	1.00
Mapk	associated_with	pathway	1.00
Mtor	associated_with	pathway	1.00
Angiogenesis	activates	pathway	1.00
Als	expressed_in	disease	1.00
Apoptosis	activates	pathway	1.00
Nf-Κb	activates	pathway	1.00
Inflammation	regulates	disease	1.00
Nf-Κb	regulates	pathway	1.00
GENES	therapeutic_target	gene	1.00
Tumor	therapeutic_target	disease	1.00

Incoming (3525)

Source	Relation	Type	Str
PTEN	inhibits	gene	1.00
PTEN	activates	gene	1.00
PTEN	therapeutic_target	gene	1.00
AKT	activates	gene	1.00
MTOR	activates	gene	1.00
TNF	activates	gene	1.00
AKT	therapeutic_target	gene	1.00
AKT	regulates	gene	1.00
PTEN	regulates	gene	1.00
AKT	associated_with	gene	1.00
AKT	inhibits	gene	1.00
MTOR	inhibits	gene	1.00
MTOR	regulates	gene	1.00
MTOR	associated_with	gene	1.00
CASP3	associated_with	gene	1.00
STAT3	therapeutic_target	gene	1.00
TNF	inhibits	gene	1.00
ROS	regulates	process	1.00
MIRNAS	therapeutic_target	gene	1.00
NEURODEGENERATION	activates	gene	1.00
NEURODEGENERATION	therapeutic_target	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
APOPTOSIS	associated_with	gene	1.00
APOPTOSIS	inhibits	gene	1.00
AUTOPHAGY	therapeutic_target	gene	1.00
AUTOPHAGY	activates	gene	1.00
OXIDATIVE STRESS	activates	gene	1.00
APOPTOSIS	therapeutic_target	gene	1.00
OXIDATIVE STRESS	therapeutic_target	gene	1.00
OXIDATIVE STRESS	inhibits	gene	1.00
INSULIN RESISTANCE	activates	gene	1.00
ROS	activates	gene	1.00
AUTOPHAGY	associated_with	gene	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
NF-KB	associated_with	protein	1.00
AMYLOID	associated_with	protein	1.00
GAIN	therapeutic_target	gene	1.00
TNF	therapeutic_target	gene	1.00
AKT1	therapeutic_target	gene	1.00
ERK	therapeutic_target	gene	1.00
NEURODEGENERATION	regulates	gene	1.00
AMPK	associated_with	gene	0.98
PARKINSON'S DISEASE	associated_with	gene	0.98
Gnetupendin A	targets	compound	0.95
AFB1	inhibits	drug	0.95
alpelisib	inhibits	drug	0.95
MTOR SIGNALING	regulates	process	0.95
MTOR SIGNALING	activates	process	0.95
phillygenin	activates	drug	0.92
AKT1	downstream_of	gene	0.92

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TREM2-DAP12 Signalosome Enhancement — Boosting PI3K-AKT-mTOR	0.451	Alzheimer's disease	TREM2 agonism vs antagonism in DAM micro

Mentioning Analyses (4)

Scientific analyses that reference this entity

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.487

Synaptic pruning by microglia in early AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.503

4R-tau strain-specific spreading patterns in PSP vs CBD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.507

Blood-brain barrier transport mechanisms for antibody therapeutics

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.566

Related Papers (1)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Trem2-dependent Insl3 regulation via Dap12-Syk-PI3K pathway: A new pathogenic me [PMID:41038403]	Ye S, Wu C, Huang S, Fan H, Zhang Z et a	Genomics	2025	0

PI3K

Understanding Entity Pages

Summary

Wiki Pages (21)

PI3K — Phosphoinositide 3-Kinase

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Parkinson's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

PD Combination Therapy Matrix

NRF2 Oxidative Stress Pathway

Alzheimer's Disease

NTF4 Protein

TREM2 Mechanism Hub

GSK-3β in Neurodegeneration

Growth Factor Therapies

Autophagy Mechanisms

Tau Spreading Mechanism

ncam2

Neurotrophin Signaling Pathways in Neurodegeneration

amyloid-beta-metalloproteinases

TREM2 Microglial Signaling Pathway in Neurodegeneration

CNTN6 — Contactin 6

omega-3-fatty-acids-neurodegeneration