Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about adar: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ADAR |
| Full Name | Adenosine Deaminase Acting On RNA 1 |
| Aliases | ADAR1, ADAR, A-to-I editing enzyme, dsRNA adenosine deaminase |
| Chromosome | 1q21.3 |
| Protein Family | ADAR (ADAR1, ADARB1/ADAR2, ADARB2/ADAR3) |
| Function | ADAR1 performs several essential cellular functions |
| Subcellular Localization | the cytoplasm |
| Molecular Weight | 122 kDa |
| Amino Acids | 1226 aa |
| UniProt ID | P55265 |
| NCBI Gene ID | 235 |
| Ensembl ID | ENSG00000166510 |
| OMIM | 146920 |
| GeneCards | ADAR |
| Human Protein Atlas | ADAR |
| Associated Diseases | Neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["ADAR"]
N1["EGFR"]
N0 -->|"regulates"| N1
N2["Interferon Signaling"]
N0 -->|"activates"| N2
N3["IFIH1"]
N3 -->|"protects against"| N0
N4["neurodegeneration"]
N0 -->|"implicated in"| N4
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
class N1 gene
class N2 pathway
class N3 gene| Target | Relation | Type | Str |
|---|---|---|---|
| EGFR | regulates | gene | 0.60 |
| Interferon Signaling | activates | pathway | 0.60 |
| benchmark_ot_ad_answer_key:ADAR | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| IFIH1 | protects_against | gene | 0.60 |
| benchmark_ot_ad_answer_key:ADAR | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity