gene

IFIH1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IFIH1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections
0Hypotheses
0Analyses
22Outgoing
18Incoming
0Experiments

Summary

IFIH1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, expressed in. Associated with Cardiovascular. Connected to 38 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolIFIH1
Protein TypeReceptor
Functionencodes a critical cytoplasmic RNA helicase that serves as a pattern recognition receptor for viral RNA.
Primary Expressionneurons, astrocytes, and microglia - Upregulated during viral infections - Elevated in neurodegenerative
PathwaysInterferon Signaling
Ensembl IDENSG00000165178
GeneCardsIFIH1
Human Protein AtlasIFIH1
Ligand recognitionLong dsRNA (>1 kb), viral dsRNA genomes
SpecificityPicornaviruses, rotaviruses, noroviruses, some flaviviruses
ActivationBinding to viral RNA induces conformational changes
OligomerizationActivated MDA5 forms filaments on dsRNA
SignalingCARD domains interact with MAVS on mitochondria
Associated Diseasesneurodegeneration
InteractionsGNAI1, ATG16L1, GNG2, GNAI2, NOD2, GNAS
KG Connections40 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (14)

Knowledge base pages for this entity

Canonical Page

IFIH1 Gene (MDA5)

gene · 1077 words

Interferon Signaling in Neurodegeneration

mechanism · 2944 words

ADAR Gene

gene · 1749 words

MAVS Gene

gene · 1739 words

AMPD2 — Adenosine Monophosphate Deaminase 2

gene · 1710 words

DDX60 — DEAD-Box Helicase 60

gene · 983 words

Pathway Diagram

graph TD
    IFIH1["<b>IFIH1</b>"]
    Cardiovascular{"Cardiovascular"}
    IFIH1 -->|"expressed in"| Cardiovascular
    ISG15["ISG15"]
    IFIH1 -->|"associated with"| ISG15
    MMP2["MMP2"]
    IFIH1 -->|"associated with"| MMP2
    IL8["IL8"]
    IFIH1 -->|"regulates"| IL8
    GNAI1["GNAI1"]
    IFIH1 -->|"interacts with"| GNAI1
    ATG16L1["ATG16L1"]
    IFIH1 -->|"interacts with"| ATG16L1
    GNG2["GNG2"]
    IFIH1 -->|"interacts with"| GNG2
    WDR81["WDR81"]
    IFIH1 -->|"expressed in"| WDR81
    GNPTG["GNPTG"]
    IFIH1 -->|"expressed in"| GNPTG
    GNAI2["GNAI2"]
    IFIH1 -->|"interacts with"| GNAI2
    NOD2["NOD2"]
    IFIH1 -->|"interacts with"| NOD2
    GNAS["GNAS"]
    IFIH1 -->|"interacts with"| GNAS
    CXCL8["CXCL8"]
    CXCL8 -->|"associated with"| IFIH1
    IL6["IL6"]
    IL6 -->|"associated with"| IFIH1
    RAB7A["RAB7A"]
    RAB7A -->|"associated with"| IFIH1
    IL1B["IL1B"]
    IL1B -->|"associated with"| IFIH1
    CD8["CD8"]
    CD8 -->|"regulates"| IFIH1
    EGFR["EGFR"]
    EGFR -->|"associated with"| IFIH1
    HSP90AA1["HSP90AA1"]
    HSP90AA1 -->|"associated with"| IFIH1
    ACTB["ACTB"]
    ACTB -->|"associated with"| IFIH1
    AKT1["AKT1"]
    AKT1 -->|"interacts with"| IFIH1
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"interacts with"| IFIH1
    AKT["AKT"]
    AKT -->|"interacts with"| IFIH1
    GNB1["GNB1"]
    GNB1 -->|"interacts with"| IFIH1
    style IFIH1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (22)

TargetRelationTypeStr
Cardiovascularexpressed_indisease0.65
ISG15associated_withgene0.60
MMP2associated_withgene0.60
GNAI1interacts_withgene0.60
ATG16L1interacts_withgene0.60

Incoming (18)

SourceRelationTypeStr
CXCL8associated_withgene0.60
IL6associated_withgene0.60
RAB7Aassociated_withgene0.60
IL1Bassociated_withgene0.60
CD8regulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found