Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IFIH1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
IFIH1 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, associated with, expressed in. Associated with Cardiovascular. Connected to 38 entities in the SciDEX knowledge graph.
| Gene Symbol | IFIH1 |
| Protein Type | Receptor |
| Function | encodes a critical cytoplasmic RNA helicase that serves as a pattern recognition receptor for viral RNA. |
| Primary Expression | neurons, astrocytes, and microglia - Upregulated during viral infections - Elevated in neurodegenerative |
| Pathways | Interferon Signaling |
| Ensembl ID | ENSG00000165178 |
| GeneCards | IFIH1 |
| Human Protein Atlas | IFIH1 |
| Ligand recognition | Long dsRNA (>1 kb), viral dsRNA genomes |
| Specificity | Picornaviruses, rotaviruses, noroviruses, some flaviviruses |
| Activation | Binding to viral RNA induces conformational changes |
| Oligomerization | Activated MDA5 forms filaments on dsRNA |
| Signaling | CARD domains interact with MAVS on mitochondria |
| Associated Diseases | neurodegeneration |
| Interactions | GNAI1, ATG16L1, GNG2, GNAI2, NOD2, GNAS |
| KG Connections | 40 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
IFIH1["<b>IFIH1</b>"]
Cardiovascular{"Cardiovascular"}
IFIH1 -->|"expressed in"| Cardiovascular
ISG15["ISG15"]
IFIH1 -->|"associated with"| ISG15
MMP2["MMP2"]
IFIH1 -->|"associated with"| MMP2
IL8["IL8"]
IFIH1 -->|"regulates"| IL8
GNAI1["GNAI1"]
IFIH1 -->|"interacts with"| GNAI1
ATG16L1["ATG16L1"]
IFIH1 -->|"interacts with"| ATG16L1
GNG2["GNG2"]
IFIH1 -->|"interacts with"| GNG2
WDR81["WDR81"]
IFIH1 -->|"expressed in"| WDR81
GNPTG["GNPTG"]
IFIH1 -->|"expressed in"| GNPTG
GNAI2["GNAI2"]
IFIH1 -->|"interacts with"| GNAI2
NOD2["NOD2"]
IFIH1 -->|"interacts with"| NOD2
GNAS["GNAS"]
IFIH1 -->|"interacts with"| GNAS
CXCL8["CXCL8"]
CXCL8 -->|"associated with"| IFIH1
IL6["IL6"]
IL6 -->|"associated with"| IFIH1
RAB7A["RAB7A"]
RAB7A -->|"associated with"| IFIH1
IL1B["IL1B"]
IL1B -->|"associated with"| IFIH1
CD8["CD8"]
CD8 -->|"regulates"| IFIH1
EGFR["EGFR"]
EGFR -->|"associated with"| IFIH1
HSP90AA1["HSP90AA1"]
HSP90AA1 -->|"associated with"| IFIH1
ACTB["ACTB"]
ACTB -->|"associated with"| IFIH1
AKT1["AKT1"]
AKT1 -->|"interacts with"| IFIH1
AUTOPHAGY["AUTOPHAGY"]
AUTOPHAGY -->|"interacts with"| IFIH1
AKT["AKT"]
AKT -->|"interacts with"| IFIH1
GNB1["GNB1"]
GNB1 -->|"interacts with"| IFIH1
style IFIH1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cardiovascular | expressed_in | disease | 0.65 |
| ISG15 | associated_with | gene | 0.60 |
| MMP2 | associated_with | gene | 0.60 |
| GNAI1 | interacts_with | gene | 0.60 |
| ATG16L1 | interacts_with | gene | 0.60 |
| GNG2 | interacts_with | gene | 0.60 |
| WDR81 | expressed_in | gene | 0.60 |
| GNPTG | expressed_in | gene | 0.60 |
| GNAI2 | interacts_with | gene | 0.60 |
| NOD2 | interacts_with | gene | 0.60 |
| GNAS | interacts_with | gene | 0.60 |
| GNAI3 | interacts_with | gene | 0.60 |
| ADAR | protects_against | gene | 0.60 |
| EGFR | regulates | gene | 0.60 |
| IFNAR2 | implicated_in | gene | 0.60 |
| TBK1 | implicated_in | gene | 0.60 |
| IL8 | regulates | gene | 0.60 |
| Autophagy | interacts_with | pathway | 0.60 |
| Wnt | expressed_in | pathway | 0.60 |
| Akt | interacts_with | pathway | 0.60 |
| Interferon Signaling | regulates | pathway | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CXCL8 | associated_with | gene | 0.60 |
| IL6 | associated_with | gene | 0.60 |
| RAB7A | associated_with | gene | 0.60 |
| IL1B | associated_with | gene | 0.60 |
| CD8 | regulates | gene | 0.60 |
| EGFR | associated_with | gene | 0.60 |
| HSP90AA1 | associated_with | gene | 0.60 |
| ACTB | associated_with | gene | 0.60 |
| AKT1 | interacts_with | gene | 0.60 |
| AKT | interacts_with | gene | 0.60 |
| GNB1 | interacts_with | gene | 0.60 |
| AMPD2 | expressed_in | gene | 0.60 |
| ATG5 | interacts_with | gene | 0.60 |
| MAVS | interacts_with | gene | 0.60 |
| TBK1 | interacts_with | gene | 0.60 |
| CLCN7 | expressed_in | gene | 0.60 |
| RIPK2 | interacts_with | gene | 0.60 |
| AUTOPHAGY | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||