Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EGFR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
EGFR is a gene implicated in neurodegeneration research. Key relationships include: activates, therapeutic target, interacts with. Associated with AD, ADH, ALS. Connected to 1370 entities in the SciDEX knowledge graph.
| Gene Symbol | EGFR |
| Full Name | Epidermal Growth Factor Receptor |
| Protein Family | ErbB/EGFR tyrosine kinase family |
| Protein Type | Receptor |
| Function | EGFR (Epidermal Growth Factor Receptor) is a receptor tyrosine kinase that binds EGF, TGF-α, and other ligands. |
| Primary Expression | neural stem cells, astrocytes, and neurons, where it regulates neurogenesis, gliogenesis, synaptic plasti |
| Molecular Weight | 134.3 kDa |
| Pathways | Akt, Apoptosis, Autophagy, Camp Signaling, Cell Cycle |
| UniProt ID | [P00533](https://www.uniprot.org/uniprot/P00533) |
| GeneCards | EGFR |
| Human Protein Atlas | EGFR |
| Associated Diseases | AD, ADH, ALS, AMI, Aging |
| Known Drugs/Compounds | EGFR-TKI, RAPAMYCIN, QUERCETIN, tyrosine kinase inhibitors, monoclonal antibodies, osimertinib |
| Interactions | PPARG, HSPA5, MAVS, FIP200, AMBRA1, APC |
| KG Connections | 2660 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
EGFR["EGFR"] -->|"regulates"| cell_proliferation["cell proliferation"]
EGFR["EGFR"] -->|"regulates"| cell_differentiation["cell differentiation"]
EGFR["EGFR"] -->|"regulates"| apoptosis["apoptosis"]
EGFR["EGFR"] -->|"causes"| tumorigenesis["tumorigenesis"]
EGFR["EGFR"] -->|"activates"| SRC["SRC"]
EGFR["EGFR"] -->|"activates"| AKT["AKT"]
tyrosine_kinase_inhibitors["tyrosine kinase inhibitors"] -.->|"inhibits"| EGFR["EGFR"]
monoclonal_antibodies["monoclonal antibodies"] -.->|"inhibits"| EGFR["EGFR"]
GGA2["GGA2"] -->|"binds"| EGFR["EGFR"]
PIEZO1["PIEZO1"] -->|"activates"| EGFR["EGFR"]
style EGFR fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| AKT | activates | protein | 1.00 |
| SRC | activates | protein | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| Als | associated_with | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| Als | activates | disease | 1.00 |
| Wnt | activates | pathway | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Carcinoma | activates | disease | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Mapk | therapeutic_target | pathway | 1.00 |
| Carcinoma | therapeutic_target | disease | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Egfr Signaling | activates | pathway | 1.00 |
| DNA | therapeutic_target | gene | 1.00 |
| Tumor | expressed_in | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Tumor | associated_with | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| CANCER | activates | gene | 1.00 |
| Glioblastoma | activates | disease | 1.00 |
| Drug Resistance | therapeutic_target | pathway | 1.00 |
| Pi3K/Akt | therapeutic_target | pathway | 1.00 |
| Breast Cancer | therapeutic_target | disease | 1.00 |
| Colorectal Cancer | therapeutic_target | disease | 1.00 |
| Lung Cancer | therapeutic_target | disease | 1.00 |
| Lung Cancer | associated_with | disease | 1.00 |
| Lung Cancer | inhibits | disease | 1.00 |
| Lung Cancer | activates | disease | 1.00 |
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Mtor | activates | pathway | 1.00 |
| GENES | activates | gene | 1.00 |
| Mapk | activates | pathway | 1.00 |
| Mtor | therapeutic_target | pathway | 1.00 |
| Pi3K/Akt | activates | pathway | 1.00 |
| GLIOBLASTOMA | activates | gene | 1.00 |
| Lung Adenocarcinoma | associated_with | disease | 0.95 |
| colorectal cancer development | promotes | disease | 0.95 |
| colorectal cancer progression | promotes | disease | 0.95 |
| non-small-cell lung cancer | associated_with | disease | 0.95 |
| CAR T cells | binds_to | cell_type | 0.95 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PI3K | activates | gene | 1.00 |
| PI3K | therapeutic_target | gene | 1.00 |
| ERK | activates | gene | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| TP53 | associated_with | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| EGFR MUTATIONS | inhibits | gene | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| amphiregulin | binds_to | protein | 0.95 |
| panitumumab | binds_to | drug | 0.95 |
| tyrosine kinase inhibitors | inhibits | drug | 0.90 |
| monoclonal antibodies | inhibits | drug | 0.90 |
| AFB1 | activates | drug | 0.90 |
| dural Tregs | increases | cell_type | 0.90 |
| amivantamab | therapeutic_target | drug | 0.90 |
| lazertinib | therapeutic_target | drug | 0.90 |
| osimertinib | therapeutic_target | drug | 0.90 |
| Thiabendazole | binds | drug | 0.90 |
| AKT1 | therapeutic_target | gene | 0.90 |
| TP53 | therapeutic_target | gene | 0.90 |
| OXIDATIVE STRESS | therapeutic_target | gene | 0.90 |
| KRAS | inhibits | gene | 0.90 |
| ALZHEIMER'S DISEASE | associated_with | disease | 0.88 |
| Nomilin | binds | compound | 0.85 |
| GNT-III | modulates | gene | 0.85 |
| GNT-V | modulates | gene | 0.85 |
| FUT8 | modulates | gene | 0.85 |
| Thiabendazole | binds_to | drug | 0.85 |
| nomilin | binds_to | drug | 0.84 |
| EGF | activates | protein | 0.82 |
| AKT | associated_with | gene | 0.82 |
| GGA2 | binds | protein | 0.80 |
| PRKCD | associated_with | gene | 0.80 |
| AKT1 | interacts_with | gene | 0.80 |
| EGF | interacts_with | gene | 0.80 |
| PI3K | inhibits | gene | 0.80 |
| TNF | therapeutic_target | gene | 0.80 |
| VEGF | therapeutic_target | gene | 0.80 |
| STAT3 | therapeutic_target | gene | 0.80 |
| MAPK3 | therapeutic_target | gene | 0.80 |
| PI3K | associated_with | gene | 0.80 |
| KRAS | therapeutic_target | gene | 0.80 |
| INFLAMMATION | therapeutic_target | gene | 0.80 |
| CANCER | interacts_with | gene | 0.80 |
| APOPTOSIS | inhibits | gene | 0.80 |
| CDK2 | coexpressed_with | gene | 0.75 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||