protein

ANO3PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ANO3PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

ANO3 is highly expressed in the brain, particularly in the cerebellum, basal ganglia (striatum, globus pallidus), thalamus, and cortical regions. This distribution aligns with its role in motor control and coordination.

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🔬 Protein Info

Gene Symbol	ANO3PROTEIN
Function	is a member of the anoctamin family of calcium-activated chloride channels (CaCC).
Primary Expression	the brain, particularly in the cerebellum, basal ganglia (striatum, globus pallidus), thalamus, and cortical regions
Subcellular Localization	</span><span class="infobox-value">Plasma membrane, Cytoplasm, Endoplasmic reticulum</span></div>
Amino Acids	913 aa
GeneCards	ANO3PROTEIN
Human Protein Atlas	ANO3PROTEIN
Transmembrane Architecture	10 transmembrane helices with a reentrant pore loop between TM3 and TM4, a topology shared with other TMEM16 family members
Calcium Sensitivity	Intracellular calcium binding through multiple sites in the N-terminal and loop regions
Dimerization	Functional channels require dimerization, with each monomer contributing to the conducting pore
Phosphorylation	Multiple serine/threonine phosphorylation sites modulate channel activity
Cl- Equilibrium	At resting potentials, ANO3 activation depolarizes neurons toward the Cl- reversal potential (approximately -70 mV in many neurons)
Excitability Tuning	By modulating Cl- conductance, ANO3 influences action potential threshold and firing patterns
Shunting Inhibition	Increased Cl- conductance can reduce excitatory input effectiveness through shunting
Activity-Dependent Activation	Neuronal activity increases intracellular Ca2+, directly activating ANO3
Associated Diseases	Als, Alzheimer, dementia, neurodegeneration
Interactions	RBFOX1
KG Connections	19 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ano3-protein

protein · 1277 words

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Pathway Diagram

graph TD
    ANO3PROTEIN["ANO3PROTEIN"]
    neurodegeneration["neurodegeneration"]
    ANO3PROTEIN -->|"implicated_in"| neurodegeneration
    style ANO3PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning ANO3PROTEIN in their description or question text

No additional research found