Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ASO: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| SNCA | inhibits | gene | 0.87 |
| ALPHA_SYNUCLEIN | inhibits | protein | 0.87 |
| TDP-43 | targets | protein | 0.75 |
| axonal degeneration | prevents | phenotype | 0.70 |
| PARKINSONS_DISEASE | treats | disease | 0.64 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TfR1 | binds | receptor | 0.90 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.664
molecular biology | 2026-04-10 | 5 hypotheses Top: 0.657
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Plant-based dietary patterns and Alzheimer's disease risk in multiethn | clinical | Alzheimer's disease and relate | 0.950 | 0.00 | human patients | proposed | N/A |
| Microglial SIRPα expression in human Alzheimer's disease tissue | exploratory | Alzheimer's disease | 0.800 | 0.00 | human brain tissue | proposed | N/A |
| Closed-loop tFUS Enhances Glymphatic Clearance and Restores CA1 PV Int | in_vivo | Alzheimer's disease | 0.765 | 0.55 | APP/PS1 mice 8-11 months (n=10 | abandoned | $125,000 |
| tFUS Targeting EC-II SST Interneurons Restores Hippocampal-Prefrontal | in_vivo | Alzheimer's disease | 0.744 | 0.48 | hAPP-J20 mice (n=10/group x 3 | abandoned | $110,000 |
| Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy in 4R-Tau | validation | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $170,000 |
| Tau ASO Therapy | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861] | ["Han X", "Sun S", "Sun Y", "Song Q", "Z | Autophagy | 2020 | 1 |
| Retinal Müller glia alterations and their impact on ocular glymphatic clearance [PMID:41603340] | Das G, Raghunathan R, Wang L | J Alzheimers Dis | 2026 | 0 |
| The Glymphatic-Venous Axis in Brain Clearance Failure: Aquaporin-4 Dysfunction, [PMID:41226584] | ["Costea D", "Dobrin N", "Tataru C", "To | International journal of molec | 2025 | 0 |
| Longitudinal changes of blood-brain barrier and transcytolemmal water exchange p [PMID:40089221] | Xiong C, Yu Z, Yin Y | Neuroimage | 2025 | 0 |
| The future of biomarkers for vascular contributions to cognitive impairment and [PMID:40542975] | Lennon MJ, Karvelas N, Ganesh A | Geroscience | 2025 | 0 |
| P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667] | Zhang D, Zhang W, Ming C, Gao X, Yuan H, | Neuron | 2024 | 0 |
| The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117] | Balusu S, De Strooper B | Acta neuropathologica | 2024 | 0 |
| Inhibition of autophagy in microglia and macrophages exacerbates innate immune r [PMID:36652438] | Hegdekar N, Sarkar C, Bustos S, Ritzel R | Autophagy | 2023 | 0 |
| Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's [PMID:37029500] | Yan YQ, Zheng R, Liu Y, Ruan Y, Lin ZH, | Aging cell | 2023 | 0 |
| Inflammasome assembly in neurodegenerative diseases. [PMID:37633753] | Singh J, Habean ML, Panicker N | Trends in neurosciences | 2023 | 0 |
| Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like [PMID:36288697] | Li S, Fang Y, Zhang Y, Song M, Zhang X, | Cell reports | 2022 | 0 |
| Biomarker of Neuroinflammation in Parkinson's Disease. [PMID:35456966] | Liu TW, Chen CM, Chang KH | Int J Mol Sci | 2022 | 0 |
| NLRP3/caspase-1/GSDMD-mediated pyroptosis exerts a crucial role in astrocyte pat [PMID:34877938] | Li S, Sun Y, Song M, Song Y, Fang Y, Zha | JCI insight | 2021 | 0 |
| Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890] | Burillo J, Marqués P, Jiménez B, Gonzále | Cells | 2021 | 0 |
| Improvement of glymphatic-lymphatic drainage of beta-amyloid by focused ultrasou [PMID:32999351] | Lee Y, Choi Y, Park EJ | Sci Rep | 2020 | 0 |
| NLRP3 inflammasome activation drives tau pathology. [PMID:31748742] | ["Ising C", "Venegas C", "Zhang S", "Sch | Nature | 2019 | 0 |
| Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodeg [PMID:30381407] | Gordon R, Albornoz EA, Christie DC, Lang | Science translational medicine | 2018 | 0 |
| Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in tra [PMID:17021169] | ["Oakley, Holly", "Cole, Sarah L", "Loga | The Journal of neuroscience : | 2006 | 0 |
| The amyloid hypothesis of Alzheimer's disease: progress and problems on the road [PMID:12130773] | ["Hardy, John", "Selkoe, Dennis J"] | Science (New York, N.Y.) | 2002 | 0 |
Multi-agent debates referencing this entity
archived · Rounds: 2 · Score: 0.73 · 2026-04-28
closed · Rounds: 4 · Score: 0.49 · 2026-04-27
closed · Rounds: 4 · Score: 0.69 · 2026-04-21
closed · Rounds: 4 · Score: 0.50 · 2026-04-13
Hypotheses and analyses mentioning ASO in their description or question text
Score: 0.827 · alzheimers · 2026-04-16
## Mechanistic Overview Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via glymph
Score: 0.827 · alzheimers · 2026-04-07
## Mechanistic Overview Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST interneurons to resto
Score: 0.824 · neurodegeneration · 2026-04-05
## Mechanistic Overview Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 Proteinopathy Neuroinflammation in
Score: 0.822 · neurodegeneration · 2026-04-05
## Mechanistic Overview Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-Synuclein Aggregates Drives Non-Cell-
Score: 0.805 · neurodegeneration · 2026-04-05
## Mechanistic Overview Mitochondrial DAMPs-Driven AIM2 Inflammasome Activation in Neurodegeneration starts from the cla
Score: 0.804 · neurodegeneration · 2026-04-05
## Mechanistic Overview Calcium-Dysregulated mPTP Opening as an Alternative mtDNA Release Mechanism for AIM2 Inflammasom
Score: 0.803 · neurodegeneration · 2026-04-17
## Mechanistic Overview Targeting the Mechanistic Link Between AQP4 Dysfunction and Ferroptosis Prevents Both Cytotoxic
Score: 0.803 · neurodegeneration · 2026-04-05
## Mechanistic Overview Mitochondrial DNA-Driven AIM2 Inflammasome Activation in Neurodegeneration starts from the claim
Score: 0.800 · multi · 2026-04-28
Shared mechanism across AD, PD: Misfolded protein stress activates microglial NLRP3; IL-1 beta and inflammasome signalin
Score: 0.797 · alzheimers · 2026-04-07
## Mechanistic Overview Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with real-time gamma f
Score: 0.767 · alzheimers · 2026-04-12
## Mechanistic Overview Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via somato
Score: 0.762 · neurodegeneration · 2026-04-22
## Mechanistic Overview Focused Ultrasound with Microbubble Contrast Agents for Antibody CNS Delivery starts from the cl
Score: 0.760 · neurodegeneration · 2026-05-01
Antisense oligonucleotides targeting expanded GGGGCC repeats in C9orf72 offer the strongest therapeutic hypothesis by si
Score: 0.754 · alzheimers · 2026-04-07
## Mechanistic Overview Closed-loop focused ultrasound targeting CA1 PV interneurons to restore theta-gamma coupling and
Score: 0.748 · alzheimers · 2026-04-05
## Mechanistic Overview Closed-loop focused ultrasound targeting EC-II SST interneurons to restore gamma gating and bloc