Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ASTROCYTE_ACTIVATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| REACTIVE_GLIOSIS | causes | phenotype | 0.72 |
| INTERMEDIATE_FILAMENTS | activates | protein | 0.72 |
| ASTROCYTES | expressed_in | cell_type | 0.72 |
| SPINAL_CORD | expressed_in | brain_region | 0.64 |
| BRAIN | expressed_in | brain_region | 0.64 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BMAL1 | inhibits | protein | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Heterogeneous astrocyte activation states differentially imp | 0.523 | Alzheimer's disease | SEA-AD Single-Cell Analysis: Cell-Type V |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Brain atrophy patterns in anti-IgLON5 disease. [PMID:40650880] | Yogeshwar SM, Bartels F, Grüter T, Muñiz | Brain | 2026 | 0 |
| Potential diagnostic markers in Alzheimer's disease: current perspectives and fu [PMID:40911035] | Zheng M, Wang S, Jia J | Neurodegener Dis Manag | 2026 | 0 |
| Granulocyte and astrocyte markers distinguish MOG-antibody disease and neuromyel [PMID:40988129] | Furlan R, Schaedelin S, Frederiksen JL, | Brain | 2026 | 0 |
| Kidney Function, Alzheimer Disease Blood Biomarkers, and Dementia Risk in Commun [PMID:41337685] | Gasparini F, Valletta M, Vetrano DL, Ber | Neurology | 2026 | 0 |
| The role of astrocytes in Alzheimer's disease: Pathophysiology, biomarkers, and [PMID:41527736] | Abedin MJ, Kastanenka KV | J Alzheimers Dis | 2026 | 0 |
| Biomarker-integrated prognostic stagings for Alzheimer's Disease. [PMID:41622252] | Shin D, Lee S, Kim JP, Jang H, Yun J et | Nat Commun | 2026 | 0 |
| Prognostic Value of Plasma NfL and GFAP for Conversion to Alzheimer's Disease an [PMID:41703957] | Özkurt Ç, Kelicen-Uğur P | Biomarkers | 2026 | 0 |
| From scaffold to effector: reframing GFAP in neurodegeneration. [PMID:41775321] | Lu YH, Zhu XP, Li S, Zhang FN, Cai CB et | J Adv Res | 2026 | 0 |
| Translating neurofilament light chain testing into clinical practice: a multidis [PMID:41831326] | Furlan R, Di Sapio A, Ferraro D, Rossi E | Clin Chem Lab Med | 2026 | 0 |
| Role of astrocyte biomarker GFAP in early diagnosis and prognosis assessment of [PMID:41850459] | Li S, Wei S, Wang L, Yu T, Wang H et al. | Int J Biol Macromol | 2026 | 0 |
| Biocompatible Lubricant-Coated Flexible Neural Probes with Enhanced Long-Term Re [PMID:41860566] | Lee H, Lee S, Hwang KS, Kim G, Hong Y et | ACS Appl Bio Mater | 2026 | 0 |
| Ythdf2/Setd1b regulatory axis is essential for cerebellar development through re [PMID:41933071] | Ren X, Jiang J, Hu X, Zhang M, Li J et a | Mol Psychiatry | 2026 | 0 |
| Amyloid-related imaging abnormalities in Japanese patients with Alzheimer's dise [PMID:41936348] | Shimasaki R, Kurihara M, Bannai T, Hatan | J Prev Alzheimers Dis | 2026 | 0 |
| Etomidate relieves oxaliplatin-induced neuropathic pain by regulating AMPK/Nrf2/ [PMID:41936904] | Chen K, Lin Y, Han X, Zhao L, Wang J et | Mol Cell Endocrinol | 2026 | 0 |
| A Bayesian classification model for differential diagnosis of Alzheimer's diseas [PMID:41940846] | Costa T, Liloia D, Premi E, Ashton N, Ze | J Alzheimers Dis | 2026 | 0 |
| Impact of zervimesine on the neuroinflammatory biomarker GFAP and related proteo [PMID:41943055] | Di Caro V, Cho E, Thiel J, Lizama BN, Ko | Alzheimer's research & therapy | 2026 | 0 |
| Associations between air pollution and markers of neuroinflammation, synaptic dy [PMID:41944915] | Kimura K, Driscoll I, Cook N, Shahzad S, | Neurotoxicity research | 2026 | 0 |
| The role of brain MRI in autoimmune encephalitis. [PMID:41947644] | Hartung TJ, Kuchling J, Finke C | Curr Opin Neurol | 2026 | 0 |
| Assessing treatment response in multiple sclerosis. [PMID:41947653] | Föttinger F, Krajnc N, Bsteh G | Curr Opin Neurol | 2026 | 0 |
| Prognostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protei [PMID:41948987] | Kabak EG, Voermans MMC, Heijst H, Teunis | Ann Clin Transl Neurol | 2026 | 0 |