Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BRAIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | BRAIN |
| Key Genes/Proteins | FERRITINH |
| Related Diseases | TBI, ASTROCYTE_ACTIVATION, PROTEIN_AGGREGATION |
| Linked Hypotheses | 17 hypotheses |
Knowledge base pages for this entity
graph TD
BRAIN["BRAIN"]
BRAIN -->|"regulates"| Intestinal_Fat_Absorption["Intestinal Fat Absorption"]
BRAIN -->|"mediates"| Gut["Gut"]
BRAIN -->|"modulates"| Fat_Absorption["Fat Absorption"]
BRAIN -->|"interacts"| bone["bone"]
Thyroid_Hormone_Transport["Thyroid Hormone Transport"] -->|"involved_in"| BRAIN
THYROID_HORMONE["THYROID HORMONE"] -->|"regulates"| BRAIN
Gut_Microbiota["Gut Microbiota"] -->|"modulates"| BRAIN
MCT1["MCT1"] -->|"expressed in"| BRAIN
Thyroid_Hormone["Thyroid Hormone"] -->|"transports"| BRAIN
SGMS1_Circular_RNA["SGMS1 Circular RNA"] -->|"expressed in"| BRAIN
Gut_Brain_Axis["Gut-Brain Axis"] -->|"mediates"| BRAIN
Aav["Aav"] -->|"targets"| BRAIN| Target | Relation | Type | Str |
|---|---|---|---|
| Intestinal Fat Absorption | regulates | process | 0.95 |
| Gut | mediates | cell_type | 0.90 |
| Fat Absorption | modulates | process | 0.85 |
| bone | interacts_with | cell_type | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| THYROID HORMONE | regulates | entity | 0.92 |
| FERRITINH | expressed_in | protein | 0.80 |
| STRESS_RESPONSE_NEURONS | expressed_in | cell_type | 0.72 |
| TBI | regulates | disease | 0.72 |
| ASTROCYTE_ACTIVATION | expressed_in | phenotype | 0.64 |
| PROTEIN_AGGREGATION | expressed_in | phenotype | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Optogenetic viral vector delivery via tFUS-mediated blood-br | 0.557 | Alzheimer's disease | Circuit-level neural dynamics in neurode |
| Blood-Brain Barrier SPM Shuttle System | 0.550 | neurodegeneration | Neuroinflammation resolution mechanisms |
| Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A | 0.512 | neurodegeneration | What are the mechanisms by which gut mic |
| GAS6/TAM Axis Activation Stabilizes Blood-Brain Barrier to R | 0.498 | neuroinflammation | Why do TAM receptors protect against neu |
| Cholinergic Basal Forebrain-Hippocampal Circuit Protection | 0.493 | neuroscience | Circuit-level neural dynamics in neurode |
| Gut-Brain Axis M-Cell Modulation | 0.427 | - | Neuroinflammation and microglial priming |
| Gut-Brain Axis Microbiome Modulation | 0.421 | Alzheimer's disease | Neuroinflammation and microglial priming |
| Brain Insulin Resistance with Glucose Transporter Dysfunctio | 0.398 | neurodegeneration | Metabolic reprogramming in neurodegenera |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 7 hypotheses Top: 0.780
connectomics | 2026-04-16 | 0 hypotheses
immunomics | 2026-04-16 | 0 hypotheses
lipidomics | 2026-04-16 | 0 hypotheses
metabolomics | 2026-04-16 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Therapy | validation | Parkinson's Disease | 0.400 | 0.50 | mouse | proposed | $280,000 |
| AAV Serotype Comparison for LRRK2 Knockdown in PD | validation | Parkinson's Disease | 0.400 | 0.50 | mouse | proposed | $280,000 |
| Progranulin Replacement Therapy for FTD — Vector Development and Valid | clinical | ALS | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Gene Therapy: AAV Serotype Comparison for LRRK2 Knockdown | validation | Parkinson's Disease | 0.400 | 0.50 | mouse | proposed | $280,000 |
| Blood-Based Biomarker Panel for Early AD Detection | clinical | Alzheimer's Disease | 0.400 | 0.50 | cell_line | proposed | $220,000 |
| Blood-Brain Barrier Aging and Neurodegeneration — From Leakage to Neur | validation | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $130,000 |
| s:** - ALOX15 overexpression in healthy astrocytes should be protectiv | falsification | Neuroinflammation | 0.400 | 0.50 | mouse | proposed | $200,000 |
| s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice with engin | falsification | Neuroinflammation | 0.400 | 0.50 | mouse | proposed | $200,000 |
| s:** - Compare uptake with/without magnetic particles using tight junc | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $120,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Genome-Scale Meta-analysis of Host Responses to Staphylococcus aureus Identifies [PMID:40447280] | Russell CD, Goeldner-Thompson S, Smith E | J Infect Dis | 2025 | 1 |
| Pseudostellaria heterophylla polysaccharide mitigates Alzheimer's-like pathology [PMID:38750854] | He C, Jiang J, Liu J, Zhou L, Ge Y, Yang | International journal of biolo | 2024 | 1 |
| An AAV capsid reprogrammed to bind human transferrin receptor mediates brain-wid [PMID:38753766] | Huang Q, Chan KY, Wu J, Botticello-Romer | Science | 2024 | 1 |
| Targeting the transferrin receptor to transport antisense oligonucleotides acros [PMID:39141703] | Barker SJ, Thayer MB, Kim C, Tatarakis D | Sci Transl Med | 2024 | 1 |
| Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214] | Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia | J Inflamm Res | 2022 | 1 |
| Blood-brain barrier transport using a high affinity, brain-selective VNAR antibo [PMID:33241587] | Stocki P, Szary J, Rasmussen CLM, Demydc | FASEB J | 2021 | 1 |
| Transferrin receptor 1 in cancer: a new sight for cancer therapy. [PMID:30034931] | Shen Y, Li X, Dong D, Zhang B, Xue Y, Sh | American journal of cancer res | 2018 | 1 |
| Therapeutic strategies for hypertension: exploring the role of microbiota-derive [PMID:40637840] | Tortelote GG | Pediatr Nephrol | 2026 | 0 |
| Exploring the gut-kidney axis: Berberine's role in alleviating chronic kidney di [PMID:41344525] | Lu Z, Li Z, Gu S, Cai Y, Wu Y et al. | J Ethnopharmacol | 2026 | 0 |
| Rebalancing the inflammatory niche in allergic rhinitis ". [PMID:41360358] | Wang N, Tang Y | Clin Chim Acta | 2026 | 0 |
| Differentiating Damp-Heat and Cold-Damp Diarrhea in Rat Models via Gut Microbiot [PMID:41566926] | Zhang H, Song X, Mi W, Ji P, Wei Y et al | Microbiologyopen | 2026 | 0 |
| Astragaloside IV Exhibited Antidiabetic Effects by Improving Glucose Metabolism, [PMID:41947478] | Yang X, Zhu C, Liu B, Yang P, Cao Z et a | Phytother Res | 2026 | 0 |
| Cranberry extract-supplemented microbiota effluents enhance intestinal barrier i [PMID:41680408] | Cattero V, Mayer T, Veilleux A, Roussel | Scientific reports | 2026 | 0 |
| Cadmium exposure is associated with impaired ovarian function: Potential role of [PMID:41548307] | ["Li J", "Wang Y", "Huang Y", "Li N", "Z | Journal of hazardous materials | 2026 | 0 |
| A humanized transferrin receptor 1-transferrin model supports functional iron ho [PMID:41338456] | Yesiltepe M, Metkar S, Yin T, Chakrabort | The Journal of biological chem | 2026 | 0 |
| Early hypoxia-induced secretome remodeling reveals adaptive mechanisms and bioma [PMID:41699623] | Wu Q, Jiang Y, Peng L, Dang Y, You C, Li | Molecular brain | 2026 | 0 |
| MITF programs macrophage iron homeostasis to drive gut-liver inflammatory axis i [PMID:41832955] | Han D, Han L, Kang L, Liu J, Zhang N, Tu | Cell reports | 2026 | 0 |
| Astrocytic α7-nicotinic acetylcholine receptors mediate pain information process [PMID:41453579] | Teng T, Yang S, Li J, Wang H, Wu F, He Y | Neurobiology of disease | 2026 | 0 |
| Signal-Level Determinants of Cognitive Decline With PPIs versus H2RAs: Transport [PMID:41663888] | Saihati HAA, Ahmed BY, Mosaad RM, El-Gar | Molecular nutrition & food res | 2026 | 0 |
| Nicotine Suppresses Human Memory Th Cell Subsets With Preferential Effects on Ce [PMID:41928597] | Gholizadeh F, Hajiaghayi M, Rahbari N, C | Eur J Immunol | 2026 | 0 |