Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Aberrant Splicing: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| cryptic exons | associated_with | process | 0.90 |
| Amyotrophic Lateral Sclerosis | contributes_to | disease | 0.85 |
| Dipeptide Repeat Proteins | involved_in | protein | 0.85 |
| APOE mRNA | suppresses | compound | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TDP-43 Loss of Function | causes | mechanism | 0.92 |
| SRSF1 | associated_with | protein | 0.90 |
| TDP-43 mislocalization | causes | phenotype | 0.90 |
| TARDBP | causes | gene | 0.90 |
| Rbp Dysfunction | causes | phenotype | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.720
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.72 · 2026-04-12
closed · Rounds: 4 · Score: 0.88 · 2026-04-06
Hypotheses and analyses mentioning Aberrant Splicing in their description or question text
No additional research found