concept

DIPEPTIDE REPEAT PROTEINS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DIPEPTIDE REPEAT PROTEINS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

3Hypotheses

3Analyses

16Outgoing

15Incoming

0Experiments

4Debates

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💡 Concept Info

Name	DIPEPTIDE REPEAT PROTEINS
Key Genes/Proteins	FUS
Related Diseases	Amyotrophic Lateral Sclerosis, C9orf72-ALS/FTD
Related Pathways	Repeat-associated non-AUG translation

Pathway Diagram

graph TD
    DIPEPTIDE_REPEAT_PROTEINS["DIPEPTIDE REPEAT PROTEINS"]
    DIPEPTIDE_REPEAT_PROTEINS -->|"contributes to"| Neurodegeneration["Neurodegeneration"]
    DIPEPTIDE_REPEAT_PROTEINS -.biomarker for.-> Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    DIPEPTIDE_REPEAT_PROTEINS -->|"causes"| Toxic_Gain_Of_Function["Toxic Gain Of Function"]
    DIPEPTIDE_REPEAT_PROTEINS -->|"expressed in"| Motor_Cortex["Motor Cortex"]
    DIPEPTIDE_REPEAT_PROTEINS -->|"expressed in"| Spinal_Cord["Spinal Cord"]
    GSK2606414["GSK2606414"] -->|"downregulates"| DIPEPTIDE_REPEAT_PROTEINS
    Aberrant_Splicing["Aberrant Splicing"] -->|"involved_in"| DIPEPTIDE_REPEAT_PROTEINS
    Antisense_Oligonucleotides["Antisense Oligonucleotides"] -->|"downregulates"| DIPEPTIDE_REPEAT_PROTEINS
    C9ORF72["C9ORF72"] -->|"produces"| DIPEPTIDE_REPEAT_PROTEINS
    GGGGCC_repeat_RNA["GGGGCC repeat RNA"] -->|"activates"| DIPEPTIDE_REPEAT_PROTEINS

Outgoing (16)

Target	Relation	Type	Str
Neurodegeneration	contributes_to	process	0.90
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.90
Neurodegeneration	causes	process	0.90
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.90
Toxic Gain Of Function	causes	mechanism	0.85
Motor Cortex	expressed_in	brain_region	0.85
Neurodegeneration	contributes_to	process	0.85
Spinal Cord	expressed_in	brain_region	0.85
C9orf72-ALS/FTD	contributes_to	disease	0.85
FUS	interacts_with	protein	0.85
Abnormal Phase Transition	causes	process	0.85
Degeneration	causes	phenotype	0.70
Amyotrophic Lateral Sclerosis	causes	disease	0.70
Amyotrophic Lateral Sclerosis	associated_with	disease	0.70
phase separation	disrupts	phenotype	0.70
RNP_condensates	disrupts	cell_type	0.70

Incoming (15)

Source	Relation	Type	Str
C9ORF72	causes	gene	0.90
Repeat-associated non-AUG translation	produces	mechanism	0.90
C9ORF72 repeat expansion	causes	gene	0.90
C9orf72 repeat expansion	causes	gene	0.90
C9orf72 ASO	inhibits	drug	0.90
C9orf72 ASO	reduces	drug	0.90
C9ORF72	associated_with	gene	0.85
GSK2606414	downregulates	drug	0.85
Aberrant Splicing	involved_in	process	0.85
Antisense Oligonucleotides	downregulates	drug	0.85
Repeat-Associated Non-ATG Translation	associated_with	process	0.80
C9ORF72	produces	gene	0.80
GGGGCC repeat RNA	activates	process	0.70
C9orf72 ASO	inhibits	drug	0.70
38019311	suggested to be	paper	0.60

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ASO-mediated reduction of toxic C9orf72 dipeptide repeat pro	0.760	neurodegeneration	Test
C9orf72 Hexanucleotide Repeat Dipeptide Repeat Proteins Inhi	0.738	neurodegeneration	Legacy Pre-Pipeline Hypothesis Import
ATXN2 Antisense Oligonucleotides Reduce Dipeptide Repeat Pro	0.630	neurodegeneration	Test