Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SRSF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SRSF1 is a protein involved in neurodegeneration research. Key relationships include: regulates, inhibits, interacts with. Associated with Als, Cancer, Tumor. Connected to 14 entities in the SciDEX knowledge graph.
| Gene Symbol | SRSF1 |
| Full Name | Serine/Arginine Rich Splicing Factor 1 |
| Chromosome | 17q22 |
| Function | SRSF1 (Serine/Arginine Rich Splicing Factor 1), also known as ASF/SF2, is a member of the serine/arginine (SR) family of splicing factors. |
| Molecular Weight | 28 kDa |
| Amino Acids | 248 aa |
| Pathways | Mtor, Oxidative Stress |
| UniProt ID | P07919 |
| NCBI Gene ID | 6732 |
| Ensembl ID | ENSG00000136450 |
| OMIM | 603364 |
| GeneCards | SRSF1 |
| Human Protein Atlas | SRSF1 |
| Associated Diseases | ALS |
| Known Drugs/Compounds | Antisense Oligonucleotides |
| Interactions | BECLIN1, PIK3C3, LC3, SRSF2, VEGF, AUTOPHAGY |
| KG Connections | 47 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SRSF1["<b>SRSF1</b>"]
autophagy["autophagy"]
SRSF1 -->|"inhibits"| autophagy
PIK3C3["PIK3C3"]
SRSF1 -->|"binds"| PIK3C3
MAP1LC3["MAP1LC3"]
SRSF1 -->|"binds"| MAP1LC3
Als{"Als"}
SRSF1 -->|"regulates"| Als
Cancer{"Cancer"}
SRSF1 -->|"regulates"| Cancer
Tumor{"Tumor"}
SRSF1 -->|"regulates"| Tumor
BECLIN1["BECLIN1"]
SRSF1 -->|"interacts with"| BECLIN1
CANCER["CANCER"]
SRSF1 -->|"regulates"| CANCER
AUTOPHAGY["AUTOPHAGY"]
SRSF1 -->|"inhibits"| AUTOPHAGY
SRSF1 -->|"interacts with"| PIK3C3
LC3["LC3"]
SRSF1 -->|"inhibits"| LC3
Autophagy(["Autophagy"])
SRSF1 -->|"inhibits"| Autophagy
style SRSF1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Aberrant Splicing | associated_with | process | 0.90 |
| PIK3C3 | binds | protein | 0.80 |
| MAP1LC3 | binds | protein | 0.70 |
| Als | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Tumor | regulates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| BECLIN1 | interacts_with | gene | 0.60 |
| PIK3C3 | interacts_with | gene | 0.60 |
| LC3 | inhibits | gene | 0.60 |
| VEGF | inhibits | gene | 0.60 |
| cancer | inhibits | disease | 0.60 |
| SRSF2 | associated_with | gene | 0.60 |
| SRSF3 | associated_with | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| AUTOPHAGY | inhibits | gene | 0.60 |
| Autophagy | inhibits | pathway | 0.60 |
| Oxidative Stress | activates | pathway | 0.60 |
| AND | activates | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| MTORC1 | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| SREBP1 | activates | gene | 0.60 |
| Mtor | activates | pathway | 0.60 |
| AND | inhibits | gene | 0.60 |
| ALS | associated_with | disease | 0.60 |
| T cells | expressed_in | cell_type | 0.60 |
| frontotemporal dementia | activates | disease | 0.60 |
| SRSF2 | phosphorylates | gene | 0.55 |
| SRSF2 | co_expressed_with | gene | 0.50 |
| SRSF3 | co_expressed_with | gene | 0.50 |
| VEGF | co_expressed_with | gene | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Antisense Oligonucleotides | targets | drug | 0.80 |
| SRPK1 | regulates | gene | 0.60 |
| SRPK1 | activates | gene | 0.60 |
| SRPK1 | expressed_in | gene | 0.60 |
| SRPK1 | inhibits | gene | 0.60 |
| SF3B1 | interacts_with | gene | 0.60 |
| HNRNPA1 | associated_with | gene | 0.60 |
| HNRNPA2B1 | associated_with | gene | 0.60 |
| C9ORF72 | inhibits | gene | 0.60 |
| SFPQ | associated_with | gene | 0.60 |
| GTPBP4 | interacts_with | gene | 0.60 |
| ALS | activates | gene | 0.60 |
| SRPK1 | phosphorylates | gene | 0.55 |
| HNRNPA1 | co_expressed_with | gene | 0.50 |
| HNRNPA2B1 | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||