protein

SRSF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SRSF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

47Connections
0Hypotheses
0Analyses
32Outgoing
15Incoming

Summary

SRSF1 is a protein involved in neurodegeneration research. Key relationships include: regulates, inhibits, interacts with. Associated with Als, Cancer, Tumor. Connected to 14 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolSRSF1
Full NameSerine/Arginine Rich Splicing Factor 1
Chromosome17q22
FunctionSRSF1 (Serine/Arginine Rich Splicing Factor 1), also known as ASF/SF2, is a member of the serine/arginine (SR) family of splicing factors.
Molecular Weight28 kDa
Amino Acids248 aa
PathwaysMtor, Oxidative Stress
UniProt IDP07919
NCBI Gene ID6732
Ensembl IDENSG00000136450
OMIM603364
GeneCardsSRSF1
Human Protein AtlasSRSF1
Associated DiseasesALS
Known Drugs/CompoundsAntisense Oligonucleotides
InteractionsBECLIN1, PIK3C3, LC3, SRSF2, VEGF, AUTOPHAGY
KG Connections47 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: SRSF1 — AlphaFold P07919 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

SRSF1

gene · 519 words

TRA2B Protein - Transformer-2 Beta

protein · 4438 words

RNA Metabolism Dysregulation in Alzheimer's Disease

mechanism · 4024 words

TYNDASE — Tyndall

gene · 3964 words

4R Tau in Corticobasal Degeneration

mechanism · 3291 words

HNRNPH2 Gene

gene · 2633 words

Pathway Diagram

graph TD
    SRSF1["<b>SRSF1</b>"]
    autophagy["autophagy"]
    SRSF1 -->|"inhibits"| autophagy
    PIK3C3["PIK3C3"]
    SRSF1 -->|"binds"| PIK3C3
    MAP1LC3["MAP1LC3"]
    SRSF1 -->|"binds"| MAP1LC3
    Als{"Als"}
    SRSF1 -->|"regulates"| Als
    Cancer{"Cancer"}
    SRSF1 -->|"regulates"| Cancer
    Tumor{"Tumor"}
    SRSF1 -->|"regulates"| Tumor
    BECLIN1["BECLIN1"]
    SRSF1 -->|"interacts with"| BECLIN1
    CANCER["CANCER"]
    SRSF1 -->|"regulates"| CANCER
    AUTOPHAGY["AUTOPHAGY"]
    SRSF1 -->|"inhibits"| AUTOPHAGY
    SRSF1 -->|"interacts with"| PIK3C3
    LC3["LC3"]
    SRSF1 -->|"inhibits"| LC3
    Autophagy(["Autophagy"])
    SRSF1 -->|"inhibits"| Autophagy
    style SRSF1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (32)

TargetRelationTypeStr
Aberrant Splicingassociated_withprocess0.90
PIK3C3bindsprotein0.80
MAP1LC3bindsprotein0.70
Alsregulatesdisease0.65
Cancerregulatesdisease0.65

Incoming (15)

SourceRelationTypeStr
Antisense Oligonucleotidestargetsdrug0.80
SRPK1regulatesgene0.60
SRPK1activatesgene0.60
SRPK1expressed_ingene0.60
SRPK1inhibitsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found