Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Arginine: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| MTORC1 | activates | protein | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Arginine Methylation Enhancement Therapy | 0.653 | neurodegeneration | TDP-43 phase separation therapeutics for |
| Serine/Arginine-Rich Protein Kinase Modulation | 0.624 | neurodegeneration | TDP-43 phase separation therapeutics for |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Network pharmacology screening of ginger targets against gastric cance | exploratory | gastric cancer | 0.900 | 0.00 | computational analysis using h | proposed | N/A |
| Molecular docking validation of ginger-PRMT1 interactions | exploratory | gastric cancer | 0.800 | 0.00 | computational molecular dockin | proposed | N/A |
| Proposed experiment from debate on Microglia activate astrocytes via I | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $100,000 |
| s:** - Temporal analysis showing mitochondrial defects precede other p | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| ALS Progression Rate Heterogeneity — mechanism and biomarker predictor | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Development | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $2,280,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Predicting the molecular mechanism of ginger targeting PRMT1/BTG2 axis to inhibi [PMID:40446574] | Chen G, Gou B, Du Y, Zhou Z, Bai Y, Yang | Phytomedicine | 2025 | 1 |
| PRMT1 promotes pancreatic cancer development and resistance to chemotherapy. [PMID:38460517] | Ku B, Eisenbarth D, Baek S, Jeong TK, Ka | Cell Rep Med | 2024 | 1 |
| PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemor [PMID:38383964] | Yamamoto T, Hayashida T, Masugi Y, Oshik | Cancer Res | 2024 | 1 |
| Promising role of protein arginine methyltransferases in overcoming anti-cancer [PMID:37980859] | Zhu Y, Xia T, Chen DQ, Xiong X, Shi L, Z | Drug Resist Updat | 2024 | 1 |
| Protein arginine methylation: from enigmatic functions to therapeutic targeting. [PMID:33742187] | Wu Q, Schapira M, Arrowsmith CH, Barsyte | Nat Rev Drug Discov | 2021 | 1 |
| DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-asso [PMID:34614409] | Li Y, Xu J, Lu Y, Bian H, Yang L, Wu H, | Cell Metab | 2021 | 1 |
| Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kin [PMID:32169215] | Gou LT, Lim DH, Ma W, Aubol BE, Hao Y, W | Cell | 2020 | 1 |
| ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fert [PMID:23177736] | Zheng G, Dahl JA, Niu Y, Fedorcsak P, Hu | Mol Cell | 2013 | 1 |
| Repression of PRMT activities sensitize human homologous recombination-proficien [PMID:41632514] | ["Zhang Y", "Xu M", "Yuan J", "Hu Z", "J | eLife | 2026 | 0 |
| Ginsenoside RG3 and cantharidin synergistically suppress the progression of hepa [PMID:41501793] | ["Wang Y", "Yuan H", "Yu Y", "Gou X", "W | Journal of translational medic | 2026 | 0 |
| Palmitoylation-Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High-Fa [PMID:41610308] | Tan XH, Li KF, Yuan YM, Xia MC, Zhao FZ | Adv Sci (Weinh) | 2026 | 0 |
| Protein arginine methyltransferases in cancer: mechanisms, functions, and therap [PMID:41928257] | Jeong Y, Cho Y, Kim YK | J Biomed Sci | 2026 | 0 |
| Targeting PRMTs Creates Vulnerability of DNA Double-Stand Break Repair Pathways, [PMID:41801765] | Thiebaut C, Martinez S, Pruvost L, Eve L | Cancer science | 2026 | 0 |
| Potentiating BSEP-mediated bile acid efflux reverses first-line tyrosine kinase [PMID:41903671] | Wu Z, Wang Y, Yu B, Yu R, Chen M, Chen Z | Cancer letters | 2026 | 0 |
| LC-MS profiling of [PMID:41756837] | ["Basirattalab A", "Wallis D", "Hartel N | bioRxiv : the preprint server | 2026 | 0 |
| Discovery of the First-in-Class Protein Arginine Methyltransferase 1 PROTAC Degr [PMID:41830641] | Guo S, Li J, Lin J, Chen Y, Liu C, Liu H | Journal of medicinal chemistry | 2026 | 0 |
| PRMT1 facilitates the tumorigenesis of chronic lymphocytic leukemia by regulatin [PMID:41912914] | Tian Z, Gao P, Zhang Y, Ma J, Hu X, Wang | Leukemia | 2026 | 0 |
| PFKM governs metabolic shifts throughout skeletal muscle differentiation. [PMID:41735679] | ["Campos M", "Nguyen S", "Kong X", "Yang | Nature metabolism | 2026 | 0 |
| PRMT1-rich exosomes derived from M2 macrophages as novel therapeutics for enhanc [PMID:41610641] | ["Hong H", "Zhou C", "Wang H", "Lin C", | Tissue & cell | 2026 | 0 |
| Exercise preconditioning prevents immobilization-induced skeletal muscle atrophy [PMID:41737591] | ["Yang X", "Zou Y", "Wang H", "Niu Y", " | Sports medicine and health sci | 2026 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity