gene

CACNG7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CACNG7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

0Hypotheses

0Analyses

1Outgoing

1Incoming

0Experiments

0Debates

Summary

CACNG7 encodes TARP γ7, a neuronal auxiliary subunit critical for AMPA receptor trafficking, synaptic plasticity, and calcium channel modulation. Dysregulation contributes to Alzheimer's disease, epilepsy, and other neurological disorders.

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🧬 Gene Info

Gene Symbol	CACNG7
Full Name	Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 7
Chromosome	19q13.42
Function	regulation contributes to Alzheimer's disease
UniProt ID	[Q8TD88](https://www.uniprot.org/uniprot/Q8TD88)
Ensembl ID	ENSG00000149090
OMIM	607118
GeneCards	CACNG7
Human Protein Atlas	CACNG7
N-terminal extracellular domain	Contains multiple conserved cysteine residues
Single transmembrane helix	Spans the membrane
C-terminal intracellular domain	Contains PDZ-binding motifs for protein interactions
L-type channels (Cav1.2)	TARP γ7 modulates gating
P/Q-type channels (Cav2.1)	Associated with synaptic transmission
N-type channels (Cav2.2)	Regulation of neurotransmitter release
Associated Diseases	Alzheimer's disease, Parkinson's disease
KG Connections	2 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CACNG7 — Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 7

gene · 1635 words

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Pathway Diagram

graph TD
    CACNG7["CACNG7"]
    neurodegeneration["neurodegeneration"]
    CACNG7 -->|"implicated_in"| neurodegeneration
    style CACNG7 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00

Incoming (1)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CACNG7 in their description or question text

No additional research found