gene 1,635 words KG: CACNG7 2026-03-26
kind:genesection:genestopic:alzheimerstopic:parkinsonsstate:published
Contents

CACNG7 — Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 7

🧬 Gene Info
Gene SymbolCACNG7
Full NameCalcium Voltage-Gated Channel Auxiliary Subunit Gamma 7
Chromosome19q13.42
Functionregulation contributes to Alzheimer's disease
UniProt ID[Q8TD88](https://www.uniprot.org/uniprot/Q8TD88)
Ensembl IDENSG00000149090
OMIM607118
GeneCardsCACNG7
Human Protein AtlasCACNG7
N-terminal extracellular domainContains multiple conserved cysteine residues
Single transmembrane helixSpans the membrane
C-terminal intracellular domainContains PDZ-binding motifs for protein interactions
L-type channels (Cav1.2)TARP γ7 modulates gating
P/Q-type channels (Cav2.1)Associated with synaptic transmission
N-type channels (Cav2.2)Regulation of neurotransmitter release
Associated DiseasesAlzheimer's disease, Parkinson's disease
KG Connections2 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (16)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.57
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.68
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (6)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (2 edges)

CACNG7 provides_data_for ds-83b31ef18d49
ds-83b31ef18d49 data_in CACNG7