gene 1,635 words KG: CACNG7
Contents

CACNG7 — Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 7

🧬 Gene Info
Gene SymbolCACNG7
Full NameCalcium Voltage-Gated Channel Auxiliary Subunit Gamma 7
Chromosome19q13.42
Functionregulation contributes to Alzheimer's disease
UniProt ID[Q8TD88](https://www.uniprot.org/uniprot/Q8TD88)
Ensembl IDENSG00000149090
OMIM607118
GeneCardsCACNG7
Human Protein AtlasCACNG7
N-terminal extracellular domainContains multiple conserved cysteine residues
Single transmembrane helixSpans the membrane
C-terminal intracellular domainContains PDZ-binding motifs for protein interactions
L-type channels (Cav1.2)TARP γ7 modulates gating
P/Q-type channels (Cav2.1)Associated with synaptic transmission
N-type channels (Cav2.2)Regulation of neurotransmitter release
Associated DiseasesAlzheimer's disease, Parkinson's disease
KG Connections2 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (16)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.95
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Mechanosensitive Ion Channel Reprogramming
Score: 0.70
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67
Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65
Circadian-Gated Maresin Biosynthesis Amplification
Score: 0.56

Related Analyses (6)

Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

Knowledge Graph (2 edges)

CACNG7 provides_data_for ds-83b31ef18d49
ds-83b31ef18d49 data_in CACNG7

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