protein

CAML

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CAML: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Calcium Modulator and Cyclophilin Ligand - ER calcium channel regulator with roles in neurodegeneration and neuroinflammation

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🔬 Protein Info

Gene Symbol	CAML
Aliases	Calcium Modulator and Cyclophilin Ligand
Protein Type	Gene
Function	encodes a group of serine/threonine kinases that play critical roles in neuronal signaling, synaptic plasticity, and cognitive function.
Primary Expression	the forebrain, particularly in hippocampal CA1 neurons and cortical pyramidal cells[@lisman2002] - CAMK2B: Expressed throughout the brain, with hi
Molecular Weight	64 kDa
GeneCards	CAML
Human Protein Atlas	CAML
CAMK2A	Highly expressed in the forebrain, particularly in hippocampal CA1 neurons and cortical pyramidal cells[@lisman2002]
CAMK2B	Expressed throughout the brain, with high levels in the striatum and hippocampus
CAMK1/CAMK4	Expressed in neuronal nuclei, regulating gene expression programs
Associated Diseases	Alzheimer's disease, Parkinson's disease, ALS
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CAML Gene

gene · 628 words

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CAML Protein

protein · 2522 words

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Pathway Diagram

graph TD
    CAML["CAML"]
    neurodegeneration["neurodegeneration"]
    CAML -->|"implicated_in"| neurodegeneration
    style CAML fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning CAML in their description or question text

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