Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CASP12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Endoplasmic reticulum caspase mediating ER stress-induced apoptosis in neurodegeneration
No AI portrait yet
| Gene Symbol | CASP12 |
| Full Name | Cysteine-Containing Aspartate-Specific Protease 12 |
| Chromosome | 11q22.2 |
| Function | is a typical inactive zymogen consisting of |
| Primary Expression | Primarily in brain, muscle, and peripheral tissues |
| Amino Acids | 341 aa |
| UniProt ID | Q9Y252 |
| NCBI Gene ID | 100506658 |
| Ensembl ID | ENSG00000244045 |
| OMIM | 602394 |
| GeneCards | CASP12 |
| Human Protein Atlas | CASP12 |
| Exon 1 | Encodes the prodomain with the caspase recruitment domain (CARD) |
| Exons 2-6 | Encode the catalytic domains (p20 and p10 subunits) |
| African populations | ~60-80% express functional caspase-12 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease, ALS |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CASP12(["CASP12"])
style CASP12 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
Apoptosis(("Apoptosis"))
neurodegeneration["neurodegeneration"]
Apoptosis -->|"activates"| CASP12
CASP12 -->|"implicated_in"| neurodegeneration
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class Apoptosis pathway
class neurodegeneration disease| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CASP12 in their description or question text
No additional research found