protein 2,702 words KG: CASP12PROTEIN 2026-03-26
kind:proteinsection:proteinsstate:publishedtopic:alzheimerstopic:parkinsonstopic:als
Contents

CASP12 (Caspase-12)

🔬 Protein Info
Gene SymbolCASP12
Full NameCysteine-Containing Aspartate-Specific Protease 12
Chromosome11q22.2
Functionis a typical inactive zymogen consisting of
Primary ExpressionPrimarily in brain, muscle, and peripheral tissues
Amino Acids341 aa
UniProt IDQ9Y252
NCBI Gene ID100506658
Ensembl IDENSG00000244045
OMIM602394
GeneCardsCASP12
Human Protein AtlasCASP12
Associated DiseasesAlzheimer's disease, Parkinson's disease, ALS
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (19)

Microbial Inflammasome Priming Prevention
Score: 0.58
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
TREM2-Dependent Microglial Senescence Transition
Score: 0.69
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.59
Competitive APOE4 Domain Stabilization Peptides
Score: 0.56

Related Analyses (7)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (3)

Alpha-Synuclein Aggregation Triggers — Sporadic PD Initiatio
clinical · proposed · Score: 0.40
Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk
clinical · proposed · Score: 0.40
Microbiome-Gut Barrier Signatures in ALS — Experiment Design
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in