gene

CASP5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASP5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

CASP5 encodes caspase-5, an inflammatory caspase involved in pyroptosis, inflammasome signaling, and neuroinflammation in neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	CASP5
Full Name	Caspase 5
Chromosome	11q22.2
Protein Family	Cysteine-aspartic acid proteases
Function	is a key component of the non-canonical inflammasome pathway, which is distinct from the canonical caspase-1-dependent inflammasome.
UniProt ID	Q9U2L0
NCBI Gene ID	838
Ensembl ID	ENSG00000137757
OMIM	602665
GeneCards	CASP5
Human Protein Atlas	CASP5
Encoded Protein	Caspase-5
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CASP5 — AlphaFold Q9U2L0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CASP5["CASP5"]
    neurodegeneration["neurodegeneration"]
    CASP5 -->|"implicated_in"| neurodegeneration
    style CASP5 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity