Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CASP5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CASP5 encodes caspase-5, an inflammatory caspase involved in pyroptosis, inflammasome signaling, and neuroinflammation in neurodegenerative diseases.
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| Gene Symbol | CASP5 |
| Full Name | Caspase 5 |
| Chromosome | 11q22.2 |
| Protein Family | Cysteine-aspartic acid proteases |
| Function | is a key component of the non-canonical inflammasome pathway, which is distinct from the canonical caspase-1-dependent inflammasome. |
| UniProt ID | Q9U2L0 |
| NCBI Gene ID | 838 |
| Ensembl ID | ENSG00000137757 |
| OMIM | 602665 |
| GeneCards | CASP5 |
| Human Protein Atlas | CASP5 |
| NLRP1 | Human NLRP1 directly interacts with and activates caspase-5, forming the NLRP1 inflammasome[@Xia2019][@Tan2020]. |
| ASC adaptor | Caspase-5 can recruit ASC (PYCARD) to form inflammasome complexes. |
| Gasdermin D | Primary substrate for caspase-5-mediated cleavage. |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CASP5["CASP5"]
neurodegeneration["neurodegeneration"]
CASP5 -->|"implicated_in"| neurodegeneration
style CASP5 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CASP5 in their description or question text
No additional research found