| Gene Symbol | CASP5 |
| Full Name | Caspase 5 |
| Chromosome | 11q22.2 |
| Protein Family | Cysteine-aspartic acid proteases |
| Function | is a key component of the non-canonical inflammasome pathway, which is distinct from the canonical caspase-1-dependent inflammasome. |
| UniProt ID | Q9U2L0 |
| NCBI Gene ID | 838 |
| Ensembl ID | ENSG00000137757 |
| OMIM | 602665 |
| GeneCards | CASP5 |
| Human Protein Atlas | CASP5 |
| NLRP1 | Human NLRP1 directly interacts with and activates caspase-5, forming the NLRP1 inflammasome[@Xia2019][@Tan2020]. |
| ASC adaptor | Caspase-5 can recruit ASC (PYCARD) to form inflammasome complexes. |
| Gasdermin D | Primary substrate for caspase-5-mediated cleavage. |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
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