protein

CBLN2PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CBLN2PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

The three-dimensional structure reveals a beta-sheet rich fold that enables CBLN2 to function as a synaptic adhesion molecule, bridging presynaptic and postsynaptic membranes [4].

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🔬 Protein Info

Gene Symbol	CBLN2PROTEIN
Function	is a member of the Cerebellin family of secreted proteins that play crucial roles in synaptic connectivity and neuronal communication in the central nervous system.
Primary Expression	both cerebellar and extra-cerebellar regions
Subcellular Localization	** \| Secreted, extracellular matrix \|
Molecular Weight	32 kDa
GeneCards	CBLN2PROTEIN
Human Protein Atlas	CBLN2PROTEIN
Signal Peptide	N-terminal secretory signal sequence for extracellular targeting
Cerebellin Domain	Core domain mediating protein-protein interactions
Dimerization Capacity	Forms homodimers and heterodimers with other CBLN family members
Post-translational Modifications	Contains potential N-glycosylation sites for extracellular stability
Presynaptic Organization	Binds to presynaptic neurexin-1 isoforms to induce presynaptic differentiation
Postsynaptic Targeting	Recruits postsynaptic density proteins and glutamate receptors to synaptic sites
Synapse Maintenance	Contributes to long-term stability of established synapses
Excitatory Specificity	Primarily promotes glutamatergic excitatory synapses
Associated Diseases	neurodegeneration
Interactions	GLUD1, GRID1, Rb, SYNAPSE
KG Connections	8 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Cerebellin-2 Protein

protein · 920 words

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Pathway Diagram

graph TD
    CBLN2PROTEIN["CBLN2PROTEIN"]
    neurodegeneration["neurodegeneration"]
    CBLN2PROTEIN -->|"implicated_in"| neurodegeneration
    style CBLN2PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning CBLN2PROTEIN in their description or question text

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