gene

CCM2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCM2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Cerebral Cavernous Malformation 2 - essential scaffold protein in vascular development, blood-brain barrier function, and neurovascular unit integrity

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🧬 Gene Info

Gene Symbol	CCM2
Full Name	Cerebral Cavernous Malformation 2
Chromosome	7p13
Protein Type	Scaffold Protein
Function	encodes an essential scaffold protein that plays a critical role in vascular development, endothelial cell function, and blood-brain barrier integrity.
Primary Expression	endothelial cells (arterial, venous, and capillary), brain (cortex, hippocampus, cerebellum), heart (myocardium and vasculature), and lung (pulmonary
Molecular Weight	52 kDa
Amino Acids	444 aa
Exons	10
Pathways	TGF-β, MAPK
UniProt ID	[Q9BSQ5](https://www.uniprot.org/uniprot/Q9BSQ5)
Ensembl ID	ENSG00000168781
GeneCards	CCM2
Human Protein Atlas	CCM2
Associated Diseases	Alzheimer's disease, Stroke
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CCM2 Gene

gene · 1202 words

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CCM2 Protein

protein · 1978 words

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Pathway Diagram

graph TD
    CCM2["CCM2"]
    neurodegeneration["neurodegeneration"]
    CCM2 -->|"implicated_in"| neurodegeneration
    style CCM2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CCM2 in their description or question text

No additional research found