gene

CDC25C

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about CDC25C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

CDC25C is a dual-specificity phosphatase that regulates G2/M cell cycle checkpoint, activating CDK1 for mitotic entry. Dysregulation linked to cancer and neuronal cell cycle re-entry in AD/PD.

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🧬 Gene Info

Gene Symbol	CDC25C
Full Name	Cell Division Cycle 25C
Chromosome	5q31.2
Protein Type	Protein
Function	is a dual-specificity phosphatase that plays a critical role in cell cycle regulation by removing inhibitory phosphates from cyclin-dependent kinases (CDKs).
Subcellular Localization	The localization of CDC25C is tightly regulated throughout the cell cycle[@cdc25c_localization_2016]:
Molecular Weight	53 kDa
Amino Acids	473 aa
Exons	14
UniProt ID	Search UniProt
GeneCards	CDC25C
Human Protein Atlas	CDC25C
Activation of CDK1	CDC25C removes inhibitory phosphates from CDK1 at Tyr15 (by WEE1 kinase) and Thr14 (by MYT1 kinase)
Positive feedback loop	CDK1/cyclin B phosphorylates and activates CDC25C, creating a positive feedback loop that ensures irreversible mitotic entry
Checkpoint recovery	Following DNA repair, CDC25C activity is restored to allow cell cycle progression
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CDC25C — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CDC25C — Cell Division Cycle 25C

gene · 2230 words

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CDC25C Protein

protein · 616 words

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Pathway Diagram

graph TD
    CDC25C["CDC25C"]
    neurodegeneration["neurodegeneration"]
    CDC25C -->|"implicated_in"| neurodegeneration
    style CDC25C fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning CDC25C in their description or question text

No additional research found