Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CDC25C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CDC25C is a dual-specificity phosphatase that regulates G2/M cell cycle checkpoint, activating CDK1 for mitotic entry. Dysregulation linked to cancer and neuronal cell cycle re-entry in AD/PD.
| Gene Symbol | CDC25C |
| Full Name | CDC25C — Cell Division Cycle 25C |
| Chromosome | 5q31.2 |
| Protein Type | Protein |
| Function | is a dual-specificity phosphatase that plays a critical role in cell cycle regulation by removing inhibitory phosphates from cyclin-dependent kinases (CDKs). |
| Subcellular Localization | The localization of CDC25C is tightly regulated throughout the cell cycle[@cdc25c_localization_2016]: |
| Molecular Weight | 53 kDa |
| Amino Acids | 473 aa |
| Exons | 14 |
| UniProt ID | Search UniProt |
| NCBI Gene ID | Search NCBI |
| GeneCards | CDC25C |
| Human Protein Atlas | CDC25C |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CDC25C["CDC25C"]
neurodegeneration["neurodegeneration"]
CDC25C -->|"implicated_in"| neurodegeneration
style CDC25C fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||