Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHMP1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | CHMP1B |
| Full Name | Charged Multivesicular Body Protein 1B |
| Chromosome | 18q23 |
| Function | is a component of the ESCRT-III (Endosomal Sorting Complex Required for Transport-III) machinery, essential for endosomal membrane remodeling and multivesicular body (MVB) formation. |
| Molecular Weight | 22 kDa |
| Amino Acids | 199 aa |
| UniProt ID | [Q9Y3Q1](https://www.uniprot.org/uniprot/Q9Y3Q1) |
| Ensembl ID | ENSG00000086205 |
| GeneCards | CHMP1B |
| Human Protein Atlas | CHMP1B |
| Associated Diseases | neurodegeneration |
| Interactions | JUN, VPS4A, UBIQUITIN, JNK, ROS, C-JUN |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CHMP1B["<b>CHMP1B</b>"]
Hepatitis{"Hepatitis"}
CHMP1B -->|"activates"| Hepatitis
JUN["JUN"]
CHMP1B -->|"activates"| JUN
VPS4A["VPS4A"]
CHMP1B -->|"activates"| VPS4A
neurodegeneration["neurodegeneration"]
CHMP1B -->|"implicated in"| neurodegeneration
C_JUN["C-JUN"]
C_JUN -->|"activates"| CHMP1B
style CHMP1B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||