gene

JUN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JUN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2523Connections

3Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

JUN is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 1765 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	JUN
Full Name	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit
Chromosome	1p32.1
Protein Type	Transcription Factor
Function	c-Jun/AP-1 is a key transcription factor
Primary Expression	proliferating neural progenitors and migrating neurons, declining to lower basal levels in the adult brain
Pathways	Akt, Amyloid, Apoptosis, Autophagy, Blood-Brain Barrier
UniProt ID	P45985
NCBI Gene ID	3715
Ensembl ID	ENSG00000100994
OMIM	165160
GeneCards	JUN
Human Protein Atlas	JUN
Strategy	Compound/Mechanism
JNK inhibitors	SP600125, D-JNKI1
Associated Diseases	ALS, ALZHEIMER'S DISEASE, Addiction, Aging, Alzheimer
Known Drugs/Compounds	pokeweed mitogen, anti-CD3, burn serum, quercetin
Interactions	HCN1, HCN4, HCN2, NTN1, MIRO1, MAPT
KG Connections	2523 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: JUN — AlphaFold P45985 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    JUN["JUN"] -->|"protects against"| Alzheimer["Alzheimer"]
    JUN["JUN"] -->|"regulates"| Schizophrenia["Schizophrenia"]
    JUN["JUN"] -->|"regulates"| Epilepsy["Epilepsy"]
    JUN["JUN"] -->|"regulates"| Alzheimer["Alzheimer"]
    JUN["JUN"] -->|"regulates"| Autism["Autism"]
    JUN["JUN"] -->|"regulates"| Depression["Depression"]
    JUN["JUN"] -->|"regulates"| Bipolar["Bipolar"]
    JUN["JUN"] -->|"regulates"| Ms["Ms"]
    JUN["JUN"] -.->|"inhibits"| Epilepsy["Epilepsy"]
    JUN["JUN"] -.->|"inhibits"| Ms["Ms"]
    JUN["JUN"] -.->|"inhibits"| Als["Als"]
    JUN["JUN"] -->|"therapeutic target"| Cancer["Cancer"]
    style JUN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Schizophrenia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Epilepsy fill:#ef5350,stroke:#333,color:#e0e0e0
    style Autism fill:#ef5350,stroke:#333,color:#e0e0e0
    style Depression fill:#ef5350,stroke:#333,color:#e0e0e0
    style Bipolar fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (1520)

Target	Relation	Type	Str
Cancer	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
Als	activates	disease	1.00
Apoptosis	activates	pathway	1.00
Tumor	activates	disease	1.00
Inflammation	activates	disease	1.00
Tumor	therapeutic_target	disease	1.00
Neurodegeneration	activates	disease	1.00
Inflammation	regulates	disease	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
GENES	therapeutic_target	gene	1.00
Cancer	activates	disease	0.95
Cancer	inhibits	disease	0.95
Inflammation	therapeutic_target	disease	0.95
Neuroinflammation	activates	disease	0.95
G0/G1 phase arrest	causes	phenotype	0.90
DNA synthesis	inhibits	phenotype	0.90
cell division	inhibits	phenotype	0.90
cell proliferation	inhibits	phenotype	0.90
endoreplication	inhibits	phenotype	0.90
CDK2	inhibits	gene	0.90
CCNA	inhibits	gene	0.90
CCNE	inhibits	gene	0.90
neoplastic transformation	causes	phenotype	0.90
fibrosarcomas	causes	disease	0.90
HDAC7	associated_with	gene	0.90
HDAC7	activates	protein	0.90
MTOR	associated_with	gene	0.90
AP-1	component_of	protein	0.90
DEPRESSION	associated_with	gene	0.90
MICROGLIA	associated_with	gene	0.90
Apoptosis	therapeutic_target	pathway	0.90
Ferroptosis	inhibits	pathway	0.90
Mapk	therapeutic_target	pathway	0.90
C-JUN	activates	gene	0.90
Mapk	activates	pathway	0.90
Oxidative Stress	activates	pathway	0.90
Alzheimer	regulates	disease	0.85
Parkinson	regulates	disease	0.85
Als	regulates	disease	0.85
Neurodegeneration	therapeutic_target	disease	0.85
Neurodegeneration	regulates	disease	0.85
Ischemia	activates	disease	0.85
Parkinson	activates	disease	0.85
Inflammation	inhibits	disease	0.85
Cancer	associated_with	disease	0.85
PD-L1	interacts_with	protein	0.85
TNF	associated_with	gene	0.82

Incoming (1003)

Source	Relation	Type	Str
P38	activates	gene	1.00
JNK	activates	gene	1.00
C-JUN	activates	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
ROS	activates	gene	1.00
ds-83b31ef18d49	data_in	dataset	1.00
TNF	activates	gene	1.00
JNK	inhibits	gene	1.00
C-JUN	regulates	gene	1.00
GENES	activates	gene	1.00
pokeweed mitogen	activates	drug	0.90
anti-CD3	activates	drug	0.90
AP-1	regulates	protein	0.90
AMYLOID	associated_with	gene	0.90
AUTOPHAGY	associated_with	gene	0.90
AKT1	therapeutic_target	gene	0.90
TNF	therapeutic_target	gene	0.90
PI3K	therapeutic_target	gene	0.90
BCL-2	activates	gene	0.90
CANCER	therapeutic_target	gene	0.90
C-JUN	inhibits	gene	0.90
C-JUN	associated_with	gene	0.90
TNF-Α	activates	gene	0.90
INFLAMMATION	regulates	gene	0.90
NEURODEGENERATION	activates	gene	0.90
APOE	associated_with	gene	0.82
AMPK	associated_with	entity	0.82
JNK signaling pathway	regulates	pathway	0.80
burn serum	activates	drug	0.80
hypoxia	activates	phenotype	0.80
PRKCD	associated_with	gene	0.80
ALS	associated_with	disease	0.80
TNF	associated_with	gene	0.80
PI3K	activates	gene	0.80
FOS	activates	gene	0.80
ERK1	activates	gene	0.80
GFAP	activates	gene	0.80
ERK	inhibits	gene	0.80
CANCER	activates	gene	0.80
INFLAMMATION	inhibits	gene	0.80
INFLAMMATION	activates	gene	0.80
HO-1	activates	gene	0.80
FERROPTOSIS	inhibits	gene	0.80
NF-ΚB	activates	gene	0.80
APOPTOSIS	therapeutic_target	gene	0.80
CANCER	inhibits	gene	0.80
CYTOKINES	activates	gene	0.80
OXIDATIVE STRESS	inhibits	gene	0.80
ASTROCYTES	activates	gene	0.80
CANCER	associated_with	gene	0.80

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
ER Stress Reduction as Adjunctive Therapy to Support Autopha	0.566	neurodegeneration	Why does iron chelation therapy worsen o
Astroglial Gap Junction Coordination via Connexin-43 Phospho	0.497	neurodegeneration	Perivascular spaces and glymphatic clear
Gap Junction Hemichannel Modulation for Controlled Mitochond	0.386	neurodegeneration	Mitochondrial transfer between neurons a

Mentioning Analyses (1)

Scientific analyses that reference this entity

What is the relative contribution of connexin-43 gap junctions vs tunneling nano

cell biology | 2026-04-12 | 2 hypotheses Top: 0.579

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
PIEZO channels link mechanical forces to uterine contractions in parturition. [PMID:41231991]	Zhang Y, Kini SA, Mishkanian SA, Yarishk	Science	2025	1
GJA1-20k and Mitochondrial Dynamics. [PMID:35399255]	Shimura D, Shaw RM	Front Physiol	2022	1
Inhibition of connexin43 improves functional recovery after ischemic brain injur [PMID:25988944]	Li X, Zhao H, Tan X, Kostrzewa RM, Du G,	Glia	2015	1
Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline [PMID:41618855]	["Ying H", "Fan H", "Wang Y", "Jiang R",	Advanced science (Weinheim, Ba	2026	0
Prenatal lipopolysaccharide exposure programs cardiac fibrosis via dysregulating [PMID:41789580]	Wen Y, Yuan Y, Zhang H, Liu Y	Molecular medicine reports	2026	0
Bladder under stress: Pathological and adaptive shifts in channel expression. [PMID:41945411]	Swärd K, Andersson KE, Uvelius B	Channels (Austin)	2026	0
The relationship between Connexin 43 (Cx43) and partner protein, human discs lar [PMID:41703342]	["Scott H", "Dong L", "Stevenson A", "Ma	Cell and tissue research	2026	0
Thermal Adaptation Inhibits the Wnt Signaling Pathway Regulating Autophagy and I [PMID:41889212]	["Song R", "Zhang Z", "Zhu S", "Fu K", "	Molecular reproduction and dev	2026	0
Identification and validation of ferroptosis-related genes for diabetic nephropa [PMID:41825713]	Duan H, Wang Y, Wang Q, Yan J, Fan X, Wu	European journal of pharmacolo	2026	0
Danggui Sini decoction attenuates intervertebral disc degeneration by regulating [PMID:41812505]	Chen S, Zhou X, Wang W, Zheng Y, Kang R,	International immunopharmacolo	2026	0
Reproductive tissue-derived stromal cells rescue fertility by coupling follicula [PMID:41888633]	["Borutinskait\u0117 V", "Krastinait\u01	Stem cells translational medic	2026	0
A Single-Cell Transcriptomic Atlas Elucidates a Microglial Gene Signature Linkin [PMID:41884157]	["Zhong R", "Yang H", "Li X", "Wang F",	Journal of inflammation resear	2026	0
Essential Role of CD63 in Maintaining Corneal Epithelial Identity in the Human L [PMID:41817143]	["Sasamoto Y", "Suzuki K", "Sato S", "Le	Investigative ophthalmology &	2026	0
Hypoxia Increases Connexin46 and Connexin43 Levels in KNS-42 Glioblastoma Cells. [PMID:41898710]	Minogue PJ, Beyer EC, Berthoud VM	International journal of molec	2026	0
Cx43 modulates malignant phenotypes in bladder cancer cells via the c-Src/PTEN/F [PMID:41910821]	["Chi Q", "Xu H", "Li H", "Ma G", "Li X"	Journal of molecular histology	2026	0
SnRNA-seq reveals the ameliorative effects of optimized Xueyu Jingshen formula o [PMID:41720010]	Bai J, Xie N, Hou Y, Yan J, Chen M, Yu S	Phytomedicine : international	2026	0
Transcriptome and alternative splicing analyses uncover immune-centric pathogene [PMID:41911957]	["Yan W", "Na L", "Tao G", "Jing L", "Yi	Gene	2026	0
Metabolites released from apoptotic cells in central nervous system orchestrates [PMID:41518198]	Xiao F, Tan X, He A, Zhou Y, Xu K et al.	Autophagy	2026	0
Efferocytosis-related biomarkers and immune infiltration in pancreatic ductal ad [PMID:41966742]	Huang S, Gu D, Xiong W	Biochem Biophys Res Commun	2026	0
Connexin and Pannexin Hemichannels: Broad-Spectrum Players in Neuroinflammatory [PMID:40956013]	["S\u00e1ez J", "Ocaranza F", "Prieto-Vi	Journal of neurochemistry	2025	0

JUN

Understanding Entity Pages

Summary

Wiki Pages (21)

JUN Gene

Progressive Supranuclear Palsy (PSP)

Alzheimer's Disease

NTF4 Protein

Autophagy Mechanisms

Neurotrophin Signaling Pathways in Neurodegeneration

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

TYNDASE — Tyndall

Lipid Peroxidation in Neurodegeneration

FOXO1 Protein

NF-kB Signaling Pathway in Neurodegeneration

er-stress-neurodegeneration

Deep Cerebellar Nuclear Neurons

Tumor Necrosis Factor Alpha (TNF-α) as a Neurodegenerative Disease Biomarker

Climbing Fiber Inputs

Amyotrophic Lateral Sclerosis (ALS)

Neurogenesis and Neurodegeneration

CR1 Gene — Complement Component 1q Receptor

Tau Pathology

MAPK9 Gene