gene

JUN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about JUN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2426Connections

12Hypotheses

0Analyses

50Outgoing

50Incoming

5Experiments

0Debates

Summary

JUN is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, inhibits. Associated with ALS, Aging, Als. Connected to 1765 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	JUN
Full Name	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit
Chromosome	1p32.1
Protein Type	Transcription Factor
Function	c-Jun/AP-1 is a key transcription factor
Primary Expression	proliferating neural progenitors and migrating neurons, declining to lower basal levels in the adult brain
Pathways	Akt, Amyloid, Apoptosis, Autophagy, Blood-Brain Barrier
UniProt ID	P45985
NCBI Gene ID	3715
Ensembl ID	ENSG00000100994
OMIM	165160
GeneCards	JUN
Human Protein Atlas	JUN
Associated Diseases	Addiction, Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	anti-CD3, burn serum, pokeweed mitogen, quercetin
Interactions	ABCA1, ABCB1, ACSL5, ACTB, Actin, AGING
KG Connections	2425 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: JUN — AlphaFold P45985 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    JUN["JUN"] -->|"protects against"| Alzheimer["Alzheimer"]
    JUN["JUN"] -->|"regulates"| Schizophrenia["Schizophrenia"]
    JUN["JUN"] -->|"regulates"| Epilepsy["Epilepsy"]
    JUN["JUN"] -->|"regulates"| Alzheimer["Alzheimer"]
    JUN["JUN"] -->|"regulates"| Autism["Autism"]
    JUN["JUN"] -->|"regulates"| Depression["Depression"]
    JUN["JUN"] -->|"regulates"| Bipolar["Bipolar"]
    JUN["JUN"] -->|"regulates"| Ms["Ms"]
    JUN["JUN"] -.->|"inhibits"| Epilepsy["Epilepsy"]
    JUN["JUN"] -.->|"inhibits"| Ms["Ms"]
    JUN["JUN"] -.->|"inhibits"| Als["Als"]
    JUN["JUN"] -->|"therapeutic target"| Cancer["Cancer"]
    style JUN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style Alzheimer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Schizophrenia fill:#ef5350,stroke:#333,color:#e0e0e0
    style Epilepsy fill:#ef5350,stroke:#333,color:#e0e0e0
    style Autism fill:#ef5350,stroke:#333,color:#e0e0e0
    style Depression fill:#ef5350,stroke:#333,color:#e0e0e0
    style Bipolar fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (1451)

Target	Relation	Type	Str
JUN	encodes	protein	0.00
benchmark_ot_ad_answer_key:JUN	data_in	dataset_row	0.00
Inflammation	activates	disease	1.00
Als	activates	disease	1.00
Cancer	therapeutic_target	disease	1.00
Apoptosis	activates	pathway	1.00
Inflammation	regulates	disease	1.00
Tumor	activates	disease	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
Neurodegeneration	activates	disease	1.00
Tumor	therapeutic_target	disease	1.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Als	therapeutic_target	disease	1.00
NEURODEGENERATION	associated_with	gene	1.00
GENES	therapeutic_target	gene	1.00
Cancer	activates	disease	0.95
Inflammation	therapeutic_target	disease	0.95
Neuroinflammation	activates	disease	0.95
Cancer	inhibits	disease	0.95
AP-1	component_of	protein	0.90
G0/G1 phase arrest	causes	phenotype	0.90
CCNE	inhibits	gene	0.90
HDAC7	activates	protein	0.90
MTOR	associated_with	gene	0.90
HDAC7	associated_with	gene	0.90
fibrosarcomas	causes	disease	0.90
neoplastic transformation	causes	phenotype	0.90
cell proliferation	inhibits	phenotype	0.90
CDK2	inhibits	gene	0.90
CCNA	inhibits	gene	0.90
DEPRESSION	associated_with	gene	0.90
DNA synthesis	inhibits	phenotype	0.90
MICROGLIA	associated_with	gene	0.90
cell division	inhibits	phenotype	0.90
endoreplication	inhibits	phenotype	0.90
Mapk	therapeutic_target	pathway	0.90
Ferroptosis	inhibits	pathway	0.90
Mapk	activates	pathway	0.90
Oxidative Stress	activates	pathway	0.90
Apoptosis	therapeutic_target	pathway	0.90
C-JUN	activates	gene	0.90
Parkinson	regulates	disease	0.85
Alzheimer	regulates	disease	0.85
Als	regulates	disease	0.85
Neurodegeneration	regulates	disease	0.85
Inflammation	inhibits	disease	0.85
Neurodegeneration	therapeutic_target	disease	0.85
Ischemia	activates	disease	0.85
Parkinson	activates	disease	0.85
PD-L1	interacts_with	protein	0.85

Incoming (975)

Source	Relation	Type	Str
JUN	encodes	gene	0.00
benchmark_ot_ad_answer_key:JUN	data_in	dataset_row	0.00
JNK	activates	gene	1.00
C-JUN	activates	gene	1.00
genes-jun	documents	wiki	1.00
ROS	activates	gene	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
ds-83b31ef18d49	data_in	dataset	1.00
P38	activates	gene	1.00
JNK	inhibits	gene	1.00
GENES	activates	gene	1.00
C-JUN	regulates	gene	1.00
TNF	activates	gene	1.00
anti-CD3	activates	drug	0.90
AP-1	regulates	protein	0.90
AMYLOID	associated_with	gene	0.90
pokeweed mitogen	activates	drug	0.90
genes-jun	describes	wiki	0.90
AUTOPHAGY	associated_with	gene	0.90
BCL-2	activates	gene	0.90
CANCER	therapeutic_target	gene	0.90
INFLAMMATION	regulates	gene	0.90
TNF-Α	activates	gene	0.90
NEURODEGENERATION	activates	gene	0.90
AKT1	targets	gene	0.90
PI3K	therapeutic_target	gene	0.90
C-JUN	inhibits	gene	0.90
TNF	therapeutic_target	gene	0.90
C-JUN	associated_with	gene	0.90
AMPK	associated_with	entity	0.82
APOE	associated_with	gene	0.82
hypoxia	activates	phenotype	0.80
PRKCD	associated_with	gene	0.80
burn serum	activates	drug	0.80
JNK signaling pathway	regulates	pathway	0.80
ALS	associated_with	disease	0.80
ERK	inhibits	gene	0.80
CANCER	activates	gene	0.80
ALZHEIMER	regulates	gene	0.80
NEURODEGENERATION	regulates	gene	0.80
NEURODEGENERATIVE DISEASES	inhibits	gene	0.80
OXIDATIVE STRESS	inhibits	gene	0.80
CYTOKINES	activates	gene	0.80
ASTROCYTES	activates	gene	0.80
CANCER	inhibits	gene	0.80
APOPTOSIS	therapeutic_target	gene	0.80
CANCER	associated_with	gene	0.80
GFAP	activates	gene	0.80
ERK1	activates	gene	0.80
INFLAMMATION	activates	gene	0.80

Targeting Hypotheses (12)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Matrix Metalloproteinase-9 and TIMP-1 Ratio in Peripheral Bl	0.735	-	What blood-brain barrier permeability ch
Matrix Metalloproteinase-9/TIMP-1 Ratio in CSF Identifies Pr	0.675	-	What blood-brain barrier permeability ch
Matrix Metalloproteinase-9 and TIMP-1 Ratio in Peripheral Bl	0.640	-	What blood-brain barrier permeability ch
The most realistic translational use of physiological SCFAs	0.610	neurodegeneration	Do physiological concentrations of SCFAs
MALAT1 Three-Way Junction as a Druggable Target for Structur	0.591	molecular-biology	What are the conserved secondary structu

Astroglial Gap Junction Coordination via Connexin-43 Phospho	0.566	neurodegeneration	Perivascular spaces and glymphatic clear
ER Stress Reduction as Adjunctive Therapy to Support Autopha	0.566	neurodegeneration	Why does iron chelation therapy worsen o
Matrix Metalloproteinase-9-Mediated Claudin-5 Cleavage Drive	0.515	-	What blood-brain barrier permeability ch
C1q-Alectinib Complexation Disrupts Tight Junction Integrity	0.445	molecular-biology	Does Alectinib truly bind C1q directly w
tight-junction remodeling is the actionable driver in: Blood	0.362	neurodegeneration	Blood-brain barrier permeability changes
Gap Junction Hemichannel Modulation for Controlled Mitochond	0.361	neurodegeneration	Mitochondrial transfer between neurons a
Endocannabinoid-Mediated Tight Junction Stabilization	0.000	-	Blood-brain barrier tight junction disru

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (5)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Cx43 and GJA1-20k overexpression effects on mitochondrial transfer	exploratory	osteoarthritis	0.950	0.00	human bone marrow-derived MSCs	completed	N/A
Cx43 knockdown effects on mitochondrial transfer	exploratory	osteoarthritis	0.900	0.00	human bone marrow-derived MSCs	proposed	N/A
Confocal imaging of MSC-chondrocyte interactions during mitochondrial	exploratory	osteoarthritis	0.850	0.00	human bone marrow-derived MSCs	proposed	N/A
Astrocyte Ferritin Iron Metabolism Dysfunction in Parkinson's Disease	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Gap Junction Dysfunction Validation in Parkinson's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
PIEZO channels link mechanical forces to uterine contractions in parturition. [PMID:41231991]	Zhang Y, Kini SA, Mishkanian SA, Yarishk	Science	2025	1
GJA1-20k and Mitochondrial Dynamics. [PMID:35399255]	Shimura D, Shaw RM	Front Physiol	2022	1
Inhibition of connexin43 improves functional recovery after ischemic brain injur [PMID:25988944]	Li X, Zhao H, Tan X, Kostrzewa RM, Du G,	Glia	2015	1
Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline [PMID:41618855]	["Ying H", "Fan H", "Wang Y", "Jiang R",	Advanced science (Weinheim, Ba	2026	0
Prenatal lipopolysaccharide exposure programs cardiac fibrosis via dysregulating [PMID:41789580]	Wen Y, Yuan Y, Zhang H, Liu Y	Molecular medicine reports	2026	0
The relationship between Connexin 43 (Cx43) and partner protein, human discs lar [PMID:41703342]	["Scott H", "Dong L", "Stevenson A", "Ma	Cell and tissue research	2026	0
Thermal Adaptation Inhibits the Wnt Signaling Pathway Regulating Autophagy and I [PMID:41889212]	["Song R", "Zhang Z", "Zhu S", "Fu K", "	Molecular reproduction and dev	2026	0
Identification and validation of ferroptosis-related genes for diabetic nephropa [PMID:41825713]	Duan H, Wang Y, Wang Q, Yan J, Fan X, Wu	European journal of pharmacolo	2026	0
Danggui Sini decoction attenuates intervertebral disc degeneration by regulating [PMID:41812505]	Chen S, Zhou X, Wang W, Zheng Y, Kang R,	International immunopharmacolo	2026	0
Reproductive tissue-derived stromal cells rescue fertility by coupling follicula [PMID:41888633]	["Borutinskait\u0117 V", "Krastinait\u01	Stem cells translational medic	2026	0
A Single-Cell Transcriptomic Atlas Elucidates a Microglial Gene Signature Linkin [PMID:41884157]	["Zhong R", "Yang H", "Li X", "Wang F",	Journal of inflammation resear	2026	0
Essential Role of CD63 in Maintaining Corneal Epithelial Identity in the Human L [PMID:41817143]	["Sasamoto Y", "Suzuki K", "Sato S", "Le	Investigative ophthalmology &	2026	0
Hypoxia Increases Connexin46 and Connexin43 Levels in KNS-42 Glioblastoma Cells. [PMID:41898710]	Minogue PJ, Beyer EC, Berthoud VM	International journal of molec	2026	0
Cx43 modulates malignant phenotypes in bladder cancer cells via the c-Src/PTEN/F [PMID:41910821]	["Chi Q", "Xu H", "Li H", "Ma G", "Li X"	Journal of molecular histology	2026	0
SnRNA-seq reveals the ameliorative effects of optimized Xueyu Jingshen formula o [PMID:41720010]	Bai J, Xie N, Hou Y, Yan J, Chen M, Yu S	Phytomedicine : international	2026	0
Transcriptome and alternative splicing analyses uncover immune-centric pathogene [PMID:41911957]	["Yan W", "Na L", "Tao G", "Jing L", "Yi	Gene	2026	0
Blood-brain barrier biomarkers. [PMID:38797540]	Zapata-Acevedo JF, Mantilla-Galindo A, V	Adv Clin Chem	2024	0
Endothelial Cell Senescence Effect on the Blood-Brain Barrier in Stroke and Cogn [PMID:39541552]	Real MGC, Falcione SR, Boghozian R	Neurology	2024	0
Blood-brain barrier biomarkers. [PMID:38797540]	Zapata-Acevedo JF, Mantilla-Galindo A, V	Advances in clinical chemistry	2024	0
Endothelial Cell Senescence Effect on the Blood-Brain Barrier in Stroke and Cogn [PMID:39541552]	["Real Maria Guadalupe C", "Falcione Sar	Neurology	2024	0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning JUN in their description or question text

JUN

Understanding Entity Pages

Summary

Wiki Pages (4)

JUN Gene

JUND Gene - JunD Transcription Factor

JUN Protein

JUNB Gene

Pathway Diagram

Outgoing (1451)

Incoming (975)

Targeting Hypotheses (12)

Mentioning Analyses (0)

Experiments (5)

Related Papers (20)

Debates (0)

Related Research

Astroglial Gap Junction Coordination via Connexin-43 Phosphorylation Modulation

ER Stress Reduction as Adjunctive Therapy to Support Autophagy

Matrix Metalloproteinase-9-Mediated Claudin-5 Cleavage Drives Early Tight Juncti

C1q-Alectinib Complexation Disrupts Tight Junction Integrity to Enable Paracellu

tight-junction remodeling is the actionable driver in: Blood-brain barrier perme

Gap Junction Hemichannel Modulation for Controlled Mitochondrial Exchange

Endocannabinoid-Mediated Tight Junction Stabilization