C-JUN

Understanding Entity Pages

This page aggregates everything SciDEX knows about C-JUN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

C-JUN is a protein involved in neurodegeneration research. Key relationships include: activates, inhibits, therapeutic target. Associated with ALS, Aging, Als. Connected to 470 entities in the SciDEX knowledge graph.

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flowchart TD
    CJUN["C-JUN<br/>Transcription Factor"]
    
    %% Upstream signaling
    JNK["JNK<br/>Stress Kinase"]
    STRESS["Cellular Stress<br/>Oxidative/ER Stress"]
    
    %% Pathways activated by C-JUN
    APOPTOSIS["Apoptosis<br/>Pathway"]
    ER_STRESS["ER Stress<br/>Response"]
    BIP["BiP/GRP78<br/>ER Chaperone"]
    
    %% Inhibited pathways
    AKT["AKT<br/>Survival Kinase"]
    PI3K["PI3K/AKT<br/>Survival Pathway"]
    
    %% Neuroinflammation
    NEUROINFLAM["Neuroinflammation"]
    INFLAMMATION["Systemic<br/>Inflammation"]
    
    %% Neurodegenerative diseases
    ALS["Amyotrophic<br/>Lateral Sclerosis"]
    PD["Parkinson's<br/>Disease"]
    MS["Multiple<br/>Sclerosis"]
    EPILEPSY["Epilepsy"]
    
    %% Cellular outcomes
    CELL_DEATH["Neuronal<br/>Cell Death"]
    NEUROPROT["Neuroprotection<br/>(Context-dependent)"]
    
    %% Connections
    STRESS --|"activates"|--> JNK
    JNK --|"phosphorylates"|--> CJUN
    
    CJUN --|"activates"|--> APOPTOSIS
    CJUN --|"activates"|--> ER_STRESS
    CJUN --|"activates"|--> BIP
    CJUN --|"inhibits"|--> AKT
    CJUN --|"inhibits"|--> PI3K
    
    CJUN --|"promotes"|--> NEUROINFLAM
    CJUN --|"activates"|--> INFLAMMATION
    
    CJUN --|"dual role"|--> ALS
    CJUN --|"contributes"|--> PD
    CJUN --|"promotes"|--> MS
    CJUN --|"triggers"|--> EPILEPSY
    
    APOPTOSIS --|"leads to"|--> CELL_DEATH
    ER_STRESS --|"can promote"|--> CELL_DEATH
    AKT --|"blocked"|--> NEUROPROT
    
    NEUROINFLAM --|"exacerbates"|--> ALS
    NEUROINFLAM --|"worsens"|--> PD
    
    %% Styling
    style CJUN fill:#006494
    style APOPTOSIS fill:#ef5350
    style ER_STRESS fill:#ef5350
    style NEUROINFLAM fill:#ef5350
    style INFLAMMATION fill:#ef5350
    style CELL_DEATH fill:#5d4400
    style ALS fill:#5d4400
    style PD fill:#5d4400
    style MS fill:#5d4400
    style EPILEPSY fill:#5d4400
    style BIP fill:#1b5e20
    style NEUROPROT fill:#1b5e20
    style JNK fill:#4a1a6b
    style AKT fill:#4a1a6b
    style PI3K fill:#4a1a6b