Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VPS4A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | VPS4A |
| Full Name | Vacuolar Protein Sorting 4 Homolog A |
| Chromosome | 16q22.1 |
| Function | encodes an AAA+ ATPase involved in endosomal sorting, multivesicular body formation, and autophagy. |
| Molecular Weight | 48 kDa |
| Amino Acids | 437 aa |
| Pathways | Autophagosome-lysosome Fusion, Autophagy, autophagy pathway |
| UniProt ID | Q9Y5X0 |
| NCBI Gene ID | 27183 |
| Ensembl ID | ENSG00000167842 |
| OMIM | 609434 |
| GeneCards | VPS4A |
| Human Protein Atlas | VPS4A |
| Protein Class | AAA+ ATPase |
| Associated Diseases | neurodegeneration |
| Known Drugs/Compounds | Aloperine |
| Interactions | SQSTM1, Rb, CANCER, APOPTOSIS, AUTOPHAGY, ROS |
| KG Connections | 80 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
VPS4A["<b>VPS4A</b>"]
Cancer{"Cancer"}
VPS4A -->|"inhibits"| Cancer
Tumor{"Tumor"}
VPS4A -->|"inhibits"| Tumor
Hepatitis{"Hepatitis"}
VPS4A -->|"activates"| Hepatitis
Autophagy(["Autophagy"])
VPS4A -->|"inhibits"| Autophagy
Tgf__(["Tgf-Beta"])
VPS4A -->|"inhibits"| Tgf__
Apoptosis(["Apoptosis"])
VPS4A -->|"inhibits"| Apoptosis
SQSTM1["SQSTM1"]
VPS4A -->|"inhibits"| SQSTM1
CANCER["CANCER"]
VPS4A -->|"inhibits"| CANCER
APOPTOSIS["APOPTOSIS"]
VPS4A -->|"inhibits"| APOPTOSIS
AUTOPHAGY["AUTOPHAGY"]
VPS4A -->|"inhibits"| AUTOPHAGY
ROS["ROS"]
VPS4A -->|"inhibits"| ROS
AND["AND"]
VPS4A -->|"interacts with"| AND
SQSTM1 -->|"inhibits"| VPS4A
C_JUN["C-JUN"]
C_JUN -->|"activates"| VPS4A
CHMP1B["CHMP1B"]
CHMP1B -->|"activates"| VPS4A
JUN["JUN"]
JUN -->|"activates"| VPS4A
APOPTOSIS -->|"inhibits"| VPS4A
LYSOSOME["LYSOSOME"]
LYSOSOME -->|"inhibits"| VPS4A
AMPK["AMPK"]
AMPK -->|"activates"| VPS4A
style VPS4A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Autophagosome-lysosome Fusion | regulates | process | 0.85 |
| Autophagy | regulates | process | 0.85 |
| Cancer | inhibits | disease | 0.65 |
| Tumor | inhibits | disease | 0.65 |
| Hepatitis | activates | disease | 0.65 |
| Lung Cancer | inhibits | disease | 0.65 |
| Diabetes | regulates | disease | 0.65 |
| Cancer | regulates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Nafld | regulates | disease | 0.65 |
| Atherosclerosis | regulates | disease | 0.65 |
| Fatty Liver | regulates | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| Infection | interacts_with | disease | 0.65 |
| SQSTM1 | inhibits | gene | 0.60 |
| SREBF1 | associated_with | gene | 0.60 |
| TFE3 | associated_with | gene | 0.60 |
| P62 | associated_with | gene | 0.60 |
| SPART | associated_with | gene | 0.60 |
| ATG14 | associated_with | gene | 0.60 |
| Rb | inhibits | protein | 0.60 |
| Autophagy | inhibits | pathway | 0.60 |
| Tgf-Β | inhibits | pathway | 0.60 |
| Apoptosis | inhibits | pathway | 0.60 |
| CANCER | inhibits | gene | 0.60 |
| APOPTOSIS | inhibits | gene | 0.60 |
| AUTOPHAGY | inhibits | gene | 0.60 |
| ROS | inhibits | gene | 0.60 |
| CANCER | regulates | gene | 0.60 |
| LIPOPHAGY | regulates | gene | 0.60 |
| SREBP1 | associated_with | gene | 0.60 |
| Lysosomal Degradation | associated_with | pathway | 0.60 |
| ROS | activates | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| Actin | inhibits | protein | 0.60 |
| Fus | inhibits | protein | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| Alzheimer's disease | inhibits | disease | 0.55 |
| cancer | inhibits | disease | 0.50 |
| LYSOSOME | inhibits | gene | 0.50 |
| AUTOPHAGOSOME | inhibits | concept | 0.50 |
| TUMOR | inhibits | disease | 0.50 |
| CELL DEATH | inhibits | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Aloperine | targets | compound | 0.95 |
| Aloperine | binds | compound | 0.90 |
| SQSTM1 | inhibits | gene | 0.60 |
| CHMP1B | activates | gene | 0.60 |
| JUN | activates | gene | 0.60 |
| TFEB | associated_with | gene | 0.60 |
| NBR1 | associated_with | gene | 0.60 |
| FOXO1 | associated_with | gene | 0.60 |
| PPARA | associated_with | gene | 0.60 |
| SQSTM1 | associated_with | gene | 0.60 |
| OPTN | associated_with | gene | 0.60 |
| PPARG | associated_with | gene | 0.60 |
| UBIQUITIN | activates | gene | 0.60 |
| JNK | activates | gene | 0.60 |
| CHMP2B | interacts_with | gene | 0.60 |
| CHMP4B | interacts_with | gene | 0.60 |
| CHMP7 | interacts_with | gene | 0.60 |
| C-JUN | activates | gene | 0.60 |
| APOPTOSIS | inhibits | gene | 0.60 |
| LYSOSOME | inhibits | gene | 0.60 |
| AUTOPHAGY | inhibits | gene | 0.60 |
| ROS | inhibits | gene | 0.60 |
| NEURODEGENERATION | regulates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| LATE | inhibits | entity | 0.60 |
| PD-L1 | inhibits | gene | 0.60 |
| CANCER | inhibits | gene | 0.60 |
| VPS4 | interacts_with | gene | 0.55 |
| VPS4 | inhibits | gene | 0.55 |
| ESCRT-III | interacts_with | gene | 0.55 |
| late | inhibits | disease | 0.50 |
| SQSTM1 | co_expressed_with | gene | 0.50 |
| MLKL | co_expressed_with | gene | 0.50 |
| VPS4 | co_expressed_with | protein | 0.50 |
| AMPK | activates | gene | 0.50 |
| Autophagy | inhibits | process | 0.50 |
| TGF | co_expressed_with | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||