gene

VPS4A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VPS4A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

80Connections
0Hypotheses
0Analyses
43Outgoing
37Incoming

Summary

Page for VPS4A — Vacuolar Protein Sorting 4 Homolog A

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🧬 Gene Info
Gene SymbolVPS4A
Full NameVacuolar Protein Sorting 4 Homolog A
Chromosome16q22.1
Functionencodes an AAA+ ATPase involved in endosomal sorting, multivesicular body formation, and autophagy.
Molecular Weight48 kDa
Amino Acids437 aa
PathwaysAutophagosome-lysosome Fusion, Autophagy, autophagy pathway
UniProt IDQ9Y5X0
NCBI Gene ID27183
Ensembl IDENSG00000167842
OMIM609434
GeneCardsVPS4A
Human Protein AtlasVPS4A
Protein ClassAAA+ ATPase
Associated Diseasesneurodegeneration
Known Drugs/CompoundsAloperine
InteractionsSQSTM1, Rb, CANCER, APOPTOSIS, AUTOPHAGY, ROS
KG Connections80 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: VPS4A — AlphaFold Q9Y5X0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (15)

Knowledge base pages for this entity

Canonical Page

VPS4A — Vacuolar Protein Sorting 4 Homolog A

gene · 1544 words

Alpha-Synuclein ESCRT-III Inhibition Mechanism

mechanism · 3574 words

Exosome Biogenesis in Neurodegeneration

mechanism · 3104 words

CHMP4B — Charged Multivesicular Body Protein 4B

gene · 2584 words

ESCRT-III Inhibition by Alpha-Synuclein in Neurodegeneration

mechanism · 2580 words

ESCRT-III Neuroprotection Therapy for Neurodegeneration

idea · 2528 words

Pathway Diagram

graph TD
    VPS4A["<b>VPS4A</b>"]
    Cancer{"Cancer"}
    VPS4A -->|"inhibits"| Cancer
    Tumor{"Tumor"}
    VPS4A -->|"inhibits"| Tumor
    Hepatitis{"Hepatitis"}
    VPS4A -->|"activates"| Hepatitis
    Autophagy(["Autophagy"])
    VPS4A -->|"inhibits"| Autophagy
    Tgf__(["Tgf-Beta"])
    VPS4A -->|"inhibits"| Tgf__
    Apoptosis(["Apoptosis"])
    VPS4A -->|"inhibits"| Apoptosis
    SQSTM1["SQSTM1"]
    VPS4A -->|"inhibits"| SQSTM1
    CANCER["CANCER"]
    VPS4A -->|"inhibits"| CANCER
    APOPTOSIS["APOPTOSIS"]
    VPS4A -->|"inhibits"| APOPTOSIS
    AUTOPHAGY["AUTOPHAGY"]
    VPS4A -->|"inhibits"| AUTOPHAGY
    ROS["ROS"]
    VPS4A -->|"inhibits"| ROS
    AND["AND"]
    VPS4A -->|"interacts with"| AND
    SQSTM1 -->|"inhibits"| VPS4A
    C_JUN["C-JUN"]
    C_JUN -->|"activates"| VPS4A
    CHMP1B["CHMP1B"]
    CHMP1B -->|"activates"| VPS4A
    JUN["JUN"]
    JUN -->|"activates"| VPS4A
    APOPTOSIS -->|"inhibits"| VPS4A
    LYSOSOME["LYSOSOME"]
    LYSOSOME -->|"inhibits"| VPS4A
    AMPK["AMPK"]
    AMPK -->|"activates"| VPS4A
    style VPS4A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (43)

TargetRelationTypeStr
Autophagosome-lysosome Fusionregulatesprocess0.85
Autophagyregulatesprocess0.85
Cancerinhibitsdisease0.65
Tumorinhibitsdisease0.65
Hepatitisactivatesdisease0.65

Incoming (37)

SourceRelationTypeStr
Aloperinetargetscompound0.95
Aloperinebindscompound0.90
SQSTM1inhibitsgene0.60
CHMP1Bactivatesgene0.60
JUNactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found