Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHRNA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CHRNA1 |
| Full Name | Cholinergic Receptor Nicotinic Alpha Subunit 1 |
| Chromosome | 2q31.1 |
| Function | CHRNA1 is a key component of the muscle-type nAChR, a pentameric ligand-gated ion channel[@changeux2020]: |
| Molecular Weight | 55 kDa |
| UniProt ID | P30530 |
| NCBI Gene ID | 1135 |
| Ensembl ID | ENSG00000138435 |
| OMIM | 100710 |
| GeneCards | CHRNA1 |
| Human Protein Atlas | CHRNA1 |
| ACh Binding | The alpha-1 subunit contains the primary acetylcholine binding site |
| Ion Channel | Forms the cation-permeable pore for Na⁺ and K⁺ influx |
| Endplate Potential | Triggers muscle fiber depolarization at the NMJ |
| Pentameric Assembly | Typically (α1)₂β1δ1ε1 in adult receptors |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CHRNA1["CHRNA1"]
neurodegeneration["neurodegeneration"]
CHRNA1 -->|"implicated_in"| neurodegeneration
style CHRNA1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity