Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CLRN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CLRN1 encodes clarin 1, a synaptic protein essential for photoreceptor and hair cell function, with mutations causing Usher syndrome type 3A and potential roles in neuronal degeneration.
| Gene Symbol | CLRN1 |
| Full Name | Clarin 1 |
| Chromosome | 3q25.31 |
| Function | encodes a member of the clarin family of synaptic proteins that are essential for the formation and maintenance of ribbon synapses in photoreceptors and inner ear hair cells[@sahly2012]. |
| Primary Expression | various brain regions and participates in synaptic signaling pathways relevant to Alzheimer's disease and [Parkinson's |
| Molecular Weight | 34 kDa |
| Amino Acids | 291 aa |
| UniProt ID | Q9NYQ5 |
| NCBI Gene ID | 79568 |
| Ensembl ID | ENSG00000163631 |
| OMIM | 605792 |
| GeneCards | CLRN1 |
| Human Protein Atlas | CLRN1 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CLRN1["CLRN1"]
neurodegeneration["neurodegeneration"]
CLRN1 -->|"implicated_in"| neurodegeneration
style CLRN1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||