Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CLRN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CLRN1 encodes clarin 1, a synaptic protein essential for photoreceptor and hair cell function, with mutations causing Usher syndrome type 3A and potential roles in neuronal degeneration.
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| Gene Symbol | CLRN1 |
| Full Name | Clarin 1 |
| Chromosome | 3q25.31 |
| Function | encodes a member of the clarin family of synaptic proteins that are essential for the formation and maintenance of ribbon synapses in photoreceptors and inner ear hair cells[@sahly2012]. |
| Primary Expression | various brain regions and participates in synaptic signaling pathways relevant to Alzheimer's disease and [Parkinson's |
| Molecular Weight | 34 kDa |
| Amino Acids | 291 aa |
| UniProt ID | Q9NYQ5 |
| NCBI Gene ID | 79568 |
| Ensembl ID | ENSG00000163631 |
| OMIM | 605792 |
| GeneCards | CLRN1 |
| Human Protein Atlas | CLRN1 |
| N-terminal extracellular domain | Contains a large extracellular loop important for protein-protein interactions |
| Four transmembrane domains | Form a rigid scaffold for membrane localization |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CLRN1["CLRN1"]
neurodegeneration["neurodegeneration"]
CLRN1 -->|"implicated_in"| neurodegeneration
style CLRN1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| genes-clrn1 | linked_to | wiki | 1.00 |
Hypotheses where this entity is a therapeutic target
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| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CLRN1 in their description or question text
No additional research found