Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CRISPR-Cas9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| CANCER GENES | targets | gene | 0.95 |
| Off-Target Editing | causes | process | 0.95 |
| Genetic Interactions | mediates | process | 0.95 |
| PLIN2 Regulation | targets | process | 0.92 |
| Human Genetic Networks | involved_in | pathway | 0.90 |
| PLIN2 | targets | protein | 0.90 |
| PLIN2 | targets | protein | 0.85 |
| SNCA | targets | gene | 0.85 |
| LRRK2 | targets | gene | 0.85 |
| PINK1 | targets | gene | 0.85 |
| Neural Tissues | targets | brain_region | 0.80 |
| SNCA | targets | gene | 0.80 |
| mitochondrial dysfunction | modulates | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| 30906402 | can directly link | paper | 0.60 |
| 41180498 | allows for precise correction of | paper | 0.60 |
| 41180498 | offers potential for | paper | 0.60 |
| 41180498 | targets | paper | 0.60 |
| 41180498 | allows precise correction of | paper | 0.60 |
| 41180498 | offers the potential for | paper | 0.60 |
| 41180498 | could mark a turning point in | paper | 0.30 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CRISPR-Cas9 in their description or question text
No additional research found