Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Cholesterol dysregulation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| Myelination | inhibits | process | 0.90 |
| mitochondrial_dysfunction | contributes_to | mechanism | 0.70 |
| lysosomal clearance impairment | causes | phenotype | 0.70 |
| neuroinflammation | associated_with | phenotype | 0.70 |
| neuroinflammation | modulates | phenotype | 0.70 |
| Neuroinflammation | contributes_to | process | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APOE4 | causes | protein | 0.90 |
| Neuroinflammation | associated_with | phenotype | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TREM2-Mediated Cholesterol Dysregulation in Microglial Senes | 0.666 | neurodegeneration | Gene expression changes in aging mouse b |
Scientific analyses that reference this entity
molecular biology | 2026-04-16 | 9 hypotheses Top: 0.824
neurodegeneration | 2026-04-03 | 6 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkins [PMID:39964974] | Dai L, Wang J, Meng L, Zhang X, Xiao T, | PLoS biology | 2025 | 0 |
| Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] | ["Chen Kai", "Li Fuyao", "Zhang Shuwen", | Journal of neuroinflammation | 2025 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Multiple Sclerosis Pathology. [PMID:29358320] | Lassmann H | Cold Spring Harbor perspective | 2018 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.71 · 2026-04-16
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
Hypotheses and analyses mentioning Cholesterol dysregulation in their description or question text
No additional research found