pathway

Myelination

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Myelination: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

527Connections

2Hypotheses

1Analyses

48Outgoing

50Incoming

Summary

Myelination is a biological pathway involved in neurodegeneration research. Key relationships include: associated with, activates, contributes to. Associated with ALS, Aging, Als. Connected to 165 entities in the SciDEX knowledge graph.

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🔀 Pathway Info

Name	Myelination
Summary	Page for Oligodendrocytes in CNS Myelination
Key Genes/Proteins	APOE4, OCN, GBA1, AQP4, CD19, GABRA1
Related Pathways	Cholesterol Dysregulation, Metabolic Reprogramming
Linked Hypotheses	2 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    AQP4["AQP4"] -->|"activates"| Myelination["Myelination"]
    CD19["CD19"] -->|"therapeutic target"| Myelination["Myelination"]
    GABRA1["GABRA1"] -->|"associated"| Myelination["Myelination"]
    GABRG2["GABRG2"] -->|"associated"| Myelination["Myelination"]
    style Myelination fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (62)

Target	Relation	Type	Str
MYELIN	inhibits	concept	0.50
MYELIN	associated_with	concept	0.50
REMYELINATION	associated_with	concept	0.50
MYELIN	interacts_with	concept	0.50
MYELIN	regulates	concept	0.50
disease	expressed_in	disease	0.50
NEURONS	expressed_in	concept	0.50
PARKINSON'S	expressed_in	concept	0.50
OLIGODENDROCYTES	expressed_in	concept	0.50
DEMYELINATION	expressed_in	concept	0.50
OLIGODENDROCYTES	associated_with	concept	0.50
CENTRAL NERVOUS SYSTEM	associated_with	concept	0.50
CELL PROLIFERATION	regulates	concept	0.50
Cognitive Impairment	inhibits	phenotype	0.50
MYELIN	activates	concept	0.50
White Matter	activates	process	0.50
REMYELINATION	activates	concept	0.50
Cortex	inhibits	brain_region	0.50
AXON	inhibits	concept	0.50
Proteins	inhibits	protein	0.50
AXON	regulates	concept	0.50
MTOR SIGNALING	regulates	concept	0.50
AXON	associated_with	concept	0.50
AXON	activates	concept	0.50
VESICLE TRAFFICKING	activates	concept	0.50
Proteins	associated_with	protein	0.50
MYELIN	causes	concept	0.50
OLIGODENDROCYTES	causes	concept	0.50
MYELIN	expressed_in	concept	0.50
GENE EXPRESSION	regulates	concept	0.50
MYELIN	protects_against	concept	0.50
DEMYELINATION	protects_against	concept	0.50
Spinal Cord	activates	cell_type	0.50
OLIGODENDROCYTES	activates	concept	0.50
disease	inhibits	disease	0.50
White Matter	inhibits	process	0.50
NEURODEGENERATIVE DISEASE	inhibits	concept	0.50
Spinal Cord	inhibits	cell_type	0.50
OLIGODENDROCYTES	regulates	concept	0.50
AXON	expressed_in	concept	0.50
Oligodendrocyte	associated_with	cell_type	0.50
Stem Cell	associated_with	cell_type	0.50
Astrocyte	associated_with	cell_type	0.50
Neural Stem Cell	associated_with	cell_type	0.50
Neuron	associated_with	cell_type	0.50
Microglia	associated_with	cell_type	0.50
Macrophage	associated_with	cell_type	0.50
T Cell	associated_with	cell_type	0.50

Incoming (465)

Source	Relation	Type	Str
APOE4	associated_with	gene	0.95
OCN	inhibits	protein	0.95
Iron	involved_in	compound	0.95
Cholesterol Dysregulation	inhibits	mechanism	0.90
Microglia Activation	regulates	process	0.85
Microglia	regulates	cell_type	0.80
GBA1	regulates	gene	0.80
Metabolic Reprogramming	enhances	mechanism	0.70
AQP4	activates	gene	0.60
CD19	therapeutic_target	gene	0.60
GABRA1	associated_with	gene	0.60
GABRG2	associated_with	gene	0.60
GPR37	inhibits	gene	0.60
C4B	associated_with	gene	0.60
TREM2	associated_with	gene	0.60
CR2	inhibits	gene	0.60
OVERVIEW	inhibits	gene	0.60
MLKL	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
RIPK1	associated_with	gene	0.60
RIPK3	associated_with	gene	0.60
SOD1	regulates	gene	0.60
TNF	associated_with	gene	0.60
VEGF	associated_with	gene	0.60
GFAP	activates	gene	0.60
COMPLEMENT	causes	gene	0.60
AQP4	causes	gene	0.60
ASTROCYTES	causes	gene	0.60
CD19	causes	gene	0.60
ASTROCYTE	causes	gene	0.60
NEUROINFLAMMATION	causes	gene	0.60
EPILEPSY	causes	gene	0.60
GABRG2	causes	gene	0.60
GABRA1	causes	gene	0.60
GENES	causes	gene	0.60
MYELIN	inhibits	gene	0.60
OLIGODENDROCYTE	inhibits	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
STROKE	associated_with	gene	0.60
BANG	activates	gene	0.60
PARKINSON	associated_with	gene	0.60
INFLAMMATION	activates	gene	0.60
CANCER	associated_with	gene	0.60
CYTOKINES	activates	gene	0.60
DISEASE-ASSOCIATED MICROGLIA	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
JUN	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
OLIGODENDROCYTE	associated_with	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Oligodendrocyte Remyelination Enhancement	0.474	neurodegeneration	Gene expression changes in aging mouse b
BMP4 Pathway Inhibition for Oligodendrocyte Myelination Supp	0.454	neurodegeneration	Cell type vulnerability in Alzheimer's D

Mentioning Analyses (1)

Scientific analyses that reference this entity

What specific molecular mechanisms link APOE4 to cholesterol dysregulation in ol

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.505

Related Papers (18)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
cGAMP Enhances Microglial/Macrophage Phagocytosis in Ischemic Stroke Via Activat [PMID:41495583]	["Li Xinyu", "Ding Huamin", "Qian Shuyu"	Inflammation	2026
The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease [PMID:41109213]	Pilat DJ, Le H, Prokopenko D, Lin CJ, Ei	Neuron	2026
Role of TREM2 in neuroinflammation. [PMID:41213496]	Abdulkhaliq AA, Alasiri G, Almoghrabi Y,	Exp Neurol	2026
Fusion of Tumor Cells with Lipid-Associated Macrophages Drives Metastatic Progre [PMID:41342370]	Cheng Y, Huang G, Liu X, Wu C, Lian J et	Cancer Res	2026
Targeting senescent EGR1(+) B cells enhances immunotherapy efficacy in esophagea [PMID:41483805]	Zhou P, Zhang Y, Zhang H, Zhao P, Guo Y	Cell Rep Med	2026
Synergistic potential of TREM2 agonists and exercise training in Alzheimer's dis [PMID:41494649]	Zhang J, St Pierre Schneider B, Muguerza	Am J Physiol Endocrinol Metab	2026
Diankuang Mengxing Decoction exerts neuroprotective effects in post-stroke depre [PMID:41534750]	Yang X, Zhao Y, Liu W, Feng J, Wu X et a	J Ethnopharmacol	2026
Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystat [PMID:41576952]	Li X, Tang X, Zeng J, Duan L, Hou Z et a	Cell	2026
TREM2 expression level is critical for microglial state, metabolic capacity and [PMID:41580393]	Feiten AF, Dahm K, Schlepckow K, van Len	Nat Commun	2026
TREM2 and microglial immunity in Alzheimer's disease: mechanisms, genetics, and [PMID:41789102]	Wang T, Liu X, Wang X, Hua F, Yan L	Front Immunol	2026
TREM2 deficiency delays postnatal microglial maturation and synaptic pruning, le [PMID:41930604]	Yang HC, Deng YS, Zhang J, Zhang T, Song	J Alzheimers Dis	2026
TREM2 in neurodegeneration and diseases. [PMID:41792456]	["Abdulkhaliq A", "Alasiri G", "Kim B",	Molecular psychiatry	2026
Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721]	Aranda-Abreu GE, Rojas-Durán F, Hernánde	Neurology international	2026
Molecular mechanism of Alzheimer's disease using integrated multi-omics. [PMID:41907842]	Alhusaini M, Mussa BM, Ilce BY, Alhaj H,	Frontiers in aging neuroscienc	2026
ANGPTL4 regulates the adipogenic-osteogenic differentiation balance of bone marr [PMID:41482017]	Huang F, Zhu Z, Xing Q, Li M	Biochimie	2026
Viral and non-viral cellular therapies for neurodegeneration. [PMID:41585268]	["Srivastav Jyotsna", "Sharma Sachin"]	Frontiers in medicine	2025
BMP4 dose dictates lineage specification bias in human periodontal ligament stem [PMID:41568233]	Li Y, Tang Q, Li L, Lin C, Guo M et al.	Front Bioeng Biotechnol	2025
Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy. [PMID:20301376]	Adam MP, Bick S, Mirzaa GM, Pagon RA, Wa		1993

Myelination

Understanding Entity Pages

Summary

Wiki Pages (21)

Oligodendrocytes in CNS Myelination

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Parkinson's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

primary-progressive-aphasia

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Corticobasal Degeneration (CBD)

Therapeutics

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Neurons — Cell Type Hierarchy

neuroinflammation

CBS/PSP Treatment Rankings

NRF2 Oxidative Stress Pathway

Multiple System Atrophy

Microglial Cells — Cell Type Hierarchy