Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Chromatin Accessibility: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| PROLIFERATION GENES | regulates | gene | 0.85 |
| INFLAMMATORY GENES | regulates | gene | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Chromatin Accessibility Restoration via BRD4 Modulation | 0.559 | neurodegeneration | Epigenetic reprogramming in aging neuron |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Sertad4 Regulates Pathological Cardiac Remodeling. [PMID:41889836] | Francois A, Bermeo-Blanco O, Nguyen BT, | bioRxiv : the preprint server | 2026 | 0 |
| Hsp70-Targeting Chimeras Enable Dual Proteasomal and Lysosomal Degradation of In [PMID:41874277] | Wang Z, Li P, Yin F, Zhang H, Wang S, Te | Journal of medicinal chemistry | 2026 | 0 |
| Cartilage targeting hydrogel nanoplatform degrades BRD4 to alleviate osteoarthri [PMID:41904167] | Zhao Q, Xu T, Du Z, Lu X, Zhang Y, Peng | Nature communications | 2026 | 0 |
| Semi-rigid linkers improve the pharmacokinetic properties and therapeutic effica [PMID:41687266] | Yu S, Hu S, Wang W, Pan C, Zhang H et al | Eur J Med Chem | 2026 | 0 |
| Molecular insights for the tumor suppressor role of SPOP in prostate cancer. [PMID:41707797] | Yan P, Xue X, Hou T, Wang J, Jiang W et | Biochim Biophys Acta Rev Cance | 2026 | 0 |
| Nutrient-driven histone acetylation underlies energy storage and mobilization. [PMID:41786244] | Chen L, Zhu L, Xiao H, Wang X, Xia F et | Mol Metab | 2026 | 0 |
| D-MBIS Nonbonded Force Field Parameters Improve Specificity and Selectivity Pred [PMID:41849667] | Macaya L, Vöhringer-Martinez E | J Phys Chem B | 2026 | 0 |
| BRD4 directs myofiber identity and metabolic adaptation through CHD4 cooperation [PMID:41957025] | Zhou Z, Liu L, Xu Z, Zhou D, Liu A et al | Nat Commun | 2026 | 0 |
| Harnessing FBXO31 with Terminal Amide-Functionalized Molecules for Targeted Prot [PMID:41963263] | Zhang C, Jin X, Zhou C, Jenkins MJ, Riha | J Am Chem Soc | 2026 | 0 |
| Designing an Osmium(II) Complex to Inhibit the Growth and Recurrence of Tumors b [PMID:41964570] | Zhu M, Jiang M, Liao W, Qi K, Li G et al | J Med Chem | 2026 | 0 |
| Design, synthesis and evaluation of novel BRD4 and RIPK3 dual inhibitors as pote [PMID:41966492] | Moukha-Chafiq O, Yatchang MF, Houghtling | Bioorg Med Chem Lett | 2026 | 0 |
| Alkyne Two-Phase Strategy: Rapid Generation of TK-285-Derived PROTACs as BRD4 De [PMID:41852276] | Yamakoshi H, Watanabe R, Segawa R, Ishih | Journal of medicinal chemistry | 2026 | 0 |
| The epigenetic and epitranscriptomic regulation of Brd4-Mettl3 axis on STING med [PMID:41917296] | Zhao J, Luo X, Wang Z, Luo W, Wu S, Ma X | Inflammation research : offici | 2026 | 0 |
| Punicalagin with anti-inflammatory activities affects Brd-4 mediated chromatin r [PMID:41807492] | Li H, Li Q, Wan T, Wang Y, Zhang S | Scientific reports | 2026 | 0 |
| Targeting BRD4-A Promising Therapeutic Option for Glioblastoma? [PMID:41828493] | Lindner M, Lisińska D, Kędzierzyńska A, | International journal of molec | 2026 | 0 |
| High-intensity interval training alleviates COPD-induced gastrocnemius muscle dy [PMID:41865095] | Zhu C, Peng W, Yang L, Zhang W | Journal of muscle research and | 2026 | 0 |
| A photothermal immune hydrogel dressing for enhanced post-melanoma resection tre [PMID:41877232] | Tan D, Zhu W, Liu S, Liao F, Xu X, Luo J | Journal of nanobiotechnology | 2026 | 0 |
| Recovery of FAM134A-mediated ER-phagy through BRD4 inhibition alleviates ethanol [PMID:40959274] | ["Lim J", "Chae C", "Yoon J", "Cho J", " | International journal of biolo | 2025 | 0 |
| A human Tau expressing zebrafish model of progressive supranuclear palsy identif [PMID:39294122] | ["Bai Q", "Shao E", "Ma D", "Jiao B", "S | Nature communications | 2024 | 0 |
| Targeted Protein O-GlcNAcylation Using Bifunctional Small Molecules. [PMID:38561350] | ["Ma B", "Khan K", "Xu T", "Xeque Amada | Journal of the American Chemic | 2024 | 0 |