concept

INFLAMMATORY GENES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INFLAMMATORY GENES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

90Connections

0Hypotheses

0Analyses

50Outgoing

6Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	INFLAMMATORY GENES
Related Diseases	ALS, Inflammation, Multiple Sclerosis, Atherosclerosis, Alzheimer
Related Pathways	Chromatin Accessibility

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    INFLAMMATORY_GENES["INFLAMMATORY GENES"]
    INFLAMMATORY_GENES -->|"regulates"| ALS["ALS"]
    INFLAMMATORY_GENES -->|"inhibits"| Inflammation["Inflammation"]
    INFLAMMATORY_GENES -->|"activates"| Multiple_Sclerosis["Multiple Sclerosis"]
    INFLAMMATORY_GENES -->|"activates"| Atherosclerosis["Atherosclerosis"]
    Chromatin_Accessibility["Chromatin Accessibility"] -->|"regulates"| INFLAMMATORY_GENES
    Oligodendrocyte["Oligodendrocyte"] -->|"upregulates"| INFLAMMATORY_GENES
    C1Q["C1Q"] -->|"regulates"| INFLAMMATORY_GENES
    C_JUN["C-JUN"] -->|"inhibits"| INFLAMMATORY_GENES
    CYTOKINES["CYTOKINES"] -->|"inhibits"| INFLAMMATORY_GENES
    PRO_INFLAMMATORY_GENES["PRO-INFLAMMATORY GENES"] -->|"inhibits"| INFLAMMATORY_GENES
    JUN["JUN"] -->|"inhibits"| INFLAMMATORY_GENES

Outgoing (83)

Target	Relation	Type	Str
ALS	regulates	disease	0.65
ALS	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Multiple Sclerosis	activates	disease	0.65
ALS	expressed_in	disease	0.65
Inflammation	expressed_in	disease	0.65
Atherosclerosis	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Tauopathy	inhibits	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Dementia	inhibits	disease	0.65
ALS	activates	disease	0.65
C1Q	regulates	gene	0.60
GENES	regulates	gene	0.60
COMPLEMENT	regulates	gene	0.60
AND	regulates	gene	0.60
Complement	regulates	pathway	0.60
Epigenetic	regulates	pathway	0.60
Glycolysis	regulates	pathway	0.60
GENES	inhibits	gene	0.60
AKT	inhibits	gene	0.60
MTORC1	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
TLR	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
NF-ΚB	inhibits	gene	0.60
MAPK	inhibits	gene	0.60
PROINFLAMMATORY CYTOKINES	inhibits	gene	0.60
JUN	inhibits	gene	0.60
C-JUN	inhibits	gene	0.60
AND	inhibits	gene	0.60
PRO-INFLAMMATORY GENES	inhibits	gene	0.60
JAK	inhibits	gene	0.60
JNK	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
Mtor	inhibits	pathway	0.60
Nf-Κb	inhibits	pathway	0.60
Pi3K/Akt	inhibits	pathway	0.60
Mapk	inhibits	pathway	0.60
Toll-Like Receptor	inhibits	pathway	0.60
GENES	activates	gene	0.60
OLIGODENDROCYTE	activates	gene	0.60
AND	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
GENES	expressed_in	gene	0.60
INFLAMMATION	expressed_in	gene	0.60
NRF2	expressed_in	gene	0.60
OXIDATIVE STRESS	expressed_in	gene	0.60

Incoming (7)

Source	Relation	Type	Str
Chromatin Accessibility	regulates	mechanism	0.85
C1Q	regulates	gene	0.60
C-JUN	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
PRO-INFLAMMATORY GENES	inhibits	gene	0.60
JUN	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

INFLAMMATORY GENES

Understanding Entity Pages

Wiki Pages (20)

Sleep and Circadian Dysfunction in Alzheimer's Disease

neuroinflammation

NRF2 Oxidative Stress Pathway

Microglial Cells — Cell Type Hierarchy

TREM2 Mechanism Hub

Astrocyte Reactivity Mechanism

GSK-3β in Neurodegeneration

APOC4 — Apolipoprotein C-IV

TREM2 Microglial Signaling Pathway in Neurodegeneration

omega-3-fatty-acids-neurodegeneration

Vitamin D Signaling Pathway in Neurodegeneration

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

Epigenetic Dysregulation in Neurodegeneration

Epigenetic Dysregulation Comparison -- AD/PD/ALS/FTD/HD

Epigenetic Alterations in Alzheimer's Disease

Glia-Neuron Crosstalk in Alzheimer's Disease

NPAS3 Gene

Neuroinflammation-Mitochondria Crosstalk Pathway