gene

HDAC2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HDAC2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

397Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

HDAC2 is a gene implicated in neurodegeneration research. Key relationships include: regulates, associated with, activates. Associated with Aging, Als, Alzheimer. Connected to 161 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HDAC2
Full Name	Histone Deacetylase 2
Chromosome	6q21
Function	HDAC2 encodes histone deacetylase 2, a class I histone deacetylase that regulates gene expression through chromatin remodeling.
Primary Expression	neurons and plays critical roles in synaptic plasticity, memory formation, and transcriptional regulation
Pathways	Apoptosis, Dna Repair, Epigenetic, Hippo, Notch
UniProt ID	[Q92769](https://www.uniprot.org/uniprot/Q92769)
Ensembl ID	ENSG00000196591
OMIM	605185
GeneCards	HDAC2
Human Protein Atlas	HDAC2
Associated Diseases	Als, Alzheimer, Cancer, Colorectal Cancer, Gastric Cancer, Hepatocellular Carcinoma
Known Drugs/Compounds	SULFORAPHANE
Interactions	HDAC3, TRKB, BDNF, EGFR, EP300, SENP1
SciDEX Hypotheses	HDAC2-Specific Repression of PU.1 Pioneer Factor T
KG Connections	397 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HDAC2["HDAC2"]
    HDAC2 -->|"regulates"| Neurodegeneration["Neurodegeneration"]
    HDAC2 -->|"regulates"| Parkinson["Parkinson"]
    HDAC2 -->|"regulates"| Alzheimer["Alzheimer"]
    HDAC2 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    HDAC2 -->|"regulates"| Inflammation["Inflammation"]
    HDAC2 -->|"regulates"| Huntington["Huntington"]
    HDAC2 -->|"regulates"| Ms["Ms"]
    HDAC2 -.biomarker for.-> Als["Als"]
    HDAC2 -->|"activates"| Anxiety["Anxiety"]
    PLEKHG5["PLEKHG5"] -->|"interacts"| HDAC2
    SIRT6["SIRT6"] -->|"regulates"| HDAC2
    HDAC11["HDAC11"] -->|"expressed in"| HDAC2
    IKBKB["IKBKB"] -.biomarker for.-> HDAC2
    PIK3R1["PIK3R1"] -.biomarker for.-> HDAC2
    GENES["GENES"] -.biomarker for.-> HDAC2
    BDNF["BDNF"] -->|"regulates"| HDAC2
    HDAC3["HDAC3"] -->|"expressed in"| HDAC2
    SIRT5["SIRT5"] -->|"regulates"| HDAC2
    HDAC7["HDAC7"] -->|"expressed in"| HDAC2

Outgoing (232)

Target	Relation	Type	Str
LAPTM4B	associated_with	gene	0.98
Autophagy	regulates	process	0.95
LAPTM4B	binds	protein	0.93
Hepatocellular Carcinoma	associated_with	disease	0.92
Pro-Inflammatory Cytokines	regulates	protein	0.90
memory loss	causes	phenotype	0.80
Histone Deacetylation	catalyzes	mechanism	0.80
epigenetic regulation	participates_in	pathway	0.80
Colorectal Cancer	associated_with	disease	0.75
Cancer	associated_with	disease	0.75
Epigenetic	regulates	pathway	0.70
HDAC3	associated_with	gene	0.65
TAU	inhibits	protein	0.65
Neurodegeneration	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Huntington	regulates	disease	0.65
Ms	regulates	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Anxiety	activates	disease	0.65
Ms	activates	disease	0.65
Depression	activates	disease	0.65
Als	regulates	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
NEURODEGENERATION	associated_with	concept	0.65
Cardiac	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Autism	expressed_in	disease	0.65
Aging	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	expressed_in	disease	0.65
Aging	inhibits	disease	0.65
Als	inhibits	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Inflammation	interacts_with	disease	0.65
Als	associated_with	disease	0.65
Gastric Cancer	associated_with	disease	0.65
Als	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Alzheimer	expressed_in	disease	0.65
Ischemia	activates	disease	0.65
Als	activates	disease	0.65
Diabetes	activates	disease	0.65
Alzheimer	activates	disease	0.65
ALS	expressed_in	disease	0.65
Carcinoma	activates	disease	0.65

Incoming (165)

Source	Relation	Type	Str
MIR34A	targets	gene	0.95
MIR34A	downregulates	gene	0.90
Creatine Phosphate	downregulates	compound	0.85
PLEKHG5	interacts_with	gene	0.80
AKT	de-SUMOylates	gene	0.80
CANCER	associated_with	gene	0.70
HDAC1	associated_with	gene	0.65
AKT	modifies	gene	0.65
SULFORAPHANE	inhibits	drug	0.65
SIRT6	regulates	gene	0.60
HDAC11	expressed_in	gene	0.60
IKBKB	biomarker_for	gene	0.60
PIK3R1	biomarker_for	gene	0.60
BDNF	regulates	gene	0.60
HDAC3	expressed_in	gene	0.60
SIRT5	regulates	gene	0.60
HDAC7	expressed_in	gene	0.60
SIRT4	regulates	gene	0.60
SIRT7	regulates	gene	0.60
HDAC6	expressed_in	gene	0.60
SIRT2	regulates	gene	0.60
SIRT1	regulates	gene	0.60
HDAC1	expressed_in	gene	0.60
KCNQ3	regulates	gene	0.60
EGFR	activates	gene	0.60
KCNQ2	regulates	gene	0.60
MECP2	regulates	gene	0.60
YY1	associated_with	gene	0.60
KDM1A	inhibits	gene	0.60
TRKB	activates	gene	0.60
UBIQUITIN	inhibits	gene	0.60
TP53	therapeutic_target	gene	0.60
TAU	regulates	gene	0.60
SIRT3	regulates	gene	0.60
IL6	interacts_with	gene	0.60
TET2	interacts_with	gene	0.60
BAX	regulates	gene	0.60
BRAF	associated_with	gene	0.60
TGFBR2	regulates	gene	0.60
ARID1A	regulates	gene	0.60
ACVR2A	regulates	gene	0.60
MRE11	associated_with	gene	0.60
MSH2	associated_with	gene	0.60
MSH3	regulates	gene	0.60
MLH1	associated_with	gene	0.60
MSH6	regulates	gene	0.60
LAPTM4B	activates	gene	0.60
HDAC8	expressed_in	gene	0.60
ANGPT1	activates	gene	0.60
SIRT1	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
HDAC2-Specific Repression of PU.1 Pioneer Factor Target Site	0.415	neurodegeneration	How does HDAC1/2 deletion specifically e

Mentioning Analyses (1)

Scientific analyses that reference this entity

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.508

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HDAC2

Understanding Entity Pages

Summary

Wiki Pages (21)

HDAC2 Gene

Epigenetic Dysregulation in Neurodegeneration

Epigenetic Dysregulation Comparison -- AD/PD/ALS/FTD/HD

Epigenetic Alterations in Alzheimer's Disease

Epigenetic Mechanisms in Alzheimer's Disease

Histone Modification Pathways in Neurodegeneration

epigenetics-neurodegeneration

Epigenetic Changes in PSP

Chromatin Remodeling in Neurodegeneration

Epigenetic Alterations in Alzheimer's Disease

PDLIM7 Epigenetic Activation in Parkinson's Disease

HDAC7 Protein

Epigenetics in Amyotrophic Lateral Sclerosis

HDAC Inhibitor Mechanism in Neurodegeneration

E2F4 Gene

Long-Term Potentiation (LTP)

Transcriptional Dysregulation in Neurodegeneration

Lactate Lactylation in Neurodegeneration

PRDM4 Gene

SIN3A Protein — SWI-Independent 3A Transcriptional Regulator