concept

CLONAL HEMATOPOIESIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLONAL HEMATOPOIESIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections

0Hypotheses

1Analyses

14Outgoing

7Incoming

0Experiments

1Debates

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💡 Concept Info

Name	CLONAL HEMATOPOIESIS

Pathway Diagram

graph TD
    CLONAL_HEMATOPOIESIS["CLONAL HEMATOPOIESIS"]
    CLONAL_HEMATOPOIESIS -->|"modulates"| Inflammatory_Profiles["Inflammatory Profiles"]
    CLONAL_HEMATOPOIESIS -->|"contributes to"| Neurodegenerative_Conditions["Neurodegenerative Conditions"]
    CLONAL_HEMATOPOIESIS -->|"risk_factor_for"| Hematologic_Malignancies["Hematologic Malignancies"]
    CLONAL_HEMATOPOIESIS -->|"contributes to"| Atherosclerotic_Cardiovascular["Atherosclerotic Cardiovascular Disease"]
    CLONAL_HEMATOPOIESIS -->|"contributes to"| Heart_Failure["Heart Failure"]
    CLONAL_HEMATOPOIESIS -->|"contributes to"| Osteoporosis["Osteoporosis"]
    CLONAL_HEMATOPOIESIS -.protects against.-> ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    CLONAL_HEMATOPOIESIS -->|"causes"| CHRONIC_INFLAMMATION["CHRONIC INFLAMMATION"]
    TET2["TET2"] -->|"involved_in"| CLONAL_HEMATOPOIESIS
    DNMT3A["DNMT3A"] -->|"contributes to"| CLONAL_HEMATOPOIESIS
    ASXL1["ASXL1"] -->|"contributes to"| CLONAL_HEMATOPOIESIS
    TP53["TP53"] -->|"contributes to"| CLONAL_HEMATOPOIESIS
    PPM1D["PPM1D"] -->|"contributes to"| CLONAL_HEMATOPOIESIS

Outgoing (14)

Target	Relation	Type	Str
Inflammatory Profiles	modulates	phenotype	0.90
Hematologic Malignancies	risk_factor_for	disease	0.90
Neurodegenerative Conditions	associated_with	disease	0.90
Chronic Inflammation	promotes	mechanism	0.90
Atherosclerotic Cardiovascular Disease	associated_with	disease	0.85
Heart Failure	associated_with	disease	0.85
Osteoporosis	contributes_to	disease	0.85
CHRONIC INFLAMMATION	causes	entity	0.85
ALZHEIMER'S DISEASE	protects_against	entity	0.85
osteoporosis	associated_with	disease	0.80
NEURODEGENERATION	associated_with	entity	0.80
Alzheimer'S Disease	protects_against	disease	0.80
Alzheimer's Disease	protects_against	disease	0.75
Alzheimer'S Disease	protective_effect	disease	0.70

Incoming (7)

Source	Relation	Type	Str
TET2	involved_in	gene	0.95
PPM1D	contributes_to	gene	0.80
TET2	contributes_to	gene	0.80
DNMT3A	contributes_to	gene	0.80
ASXL1	contributes_to	gene	0.80
TP53	contributes_to	gene	0.80
testosterone replacement therapy	associated_with	drug	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does TRT-induced erythrocytosis actually increase venous thromboembolism risk in

endocrinology | 2026-04-13 | 2 hypotheses Top: 0.653

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Despite FDA warnings and a 315% increased erythrocytosis risk with TRT, the asso

closed · Rounds: 4 · Score: 0.83 · 2026-04-14

Related Research

Hypotheses and analyses mentioning CLONAL HEMATOPOIESIS in their description or question text

No additional research found