Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TP53: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
TP53 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, activates. Associated with AD, ALI, ALS. Connected to 1476 entities in the SciDEX knowledge graph.
| Gene Symbol | TP53 |
| Full Name | Tumor Protein P53 |
| Chromosome | 17p13.1 |
| Function | p53 regulates cell cycle arrest, DNA repair, and apoptosis in response to cellular stress. |
| Primary Expression | all neuronal populations including: - Cortical neurons (layer 2-6) - Hippocampal neurons (CA1-CA3, dentate gyrus granule cells) - Dopaminergic neurons |
| Amino Acids | 393 aa |
| Exons | 11 |
| Pathways | Akt, Apoptosis, Autophagy, Blood-Brain Barrier, Cell Cycle |
| UniProt ID | [P04637](https://www.uniprot.org/uniprot/P04637) |
| Ensembl ID | ENSG00000141510 |
| GeneCards | TP53 |
| Human Protein Atlas | TP53 |
| Associated Diseases | AD, ALI, ALS, Aging, Alzheimer |
| Known Drugs/Compounds | RAPAMYCIN, Mifepristone, Tinospora cordifolia, Emodin, PC14586, CHRYSOTIXINE |
| Interactions | EFNB1, EPHB4, SRC, DNMT3A, U2AF1, TERT |
| KG Connections | 2425 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
TP53["TP53"] -->|"activates"| apoptosis["apoptosis"]
TP53["TP53"] -->|"causes"| ESCC["ESCC"]
TP53["TP53"] -->|"regulates"| cell_proliferation["cell proliferation"]
TP53["TP53"] -->|"regulates"| apoptosis_1["apoptosis"]
TP53["TP53"] -->|"regulates"| senescence["senescence"]
TP53["TP53"] -->|"encodes"| P53["P53"]
FGFR3["FGFR3"] -->|"interacts with"| TP53["TP53"]
ASXL1["ASXL1"] -->|"activates"| TP53["TP53"]
SF3B1["SF3B1"] -->|"activates"| TP53["TP53"]
TET2["TET2"] -->|"activates"| TP53["TP53"]
style TP53 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| AKT | therapeutic_target | gene | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Tumor | associated_with | disease | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Cancer | activates | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| P53 | therapeutic_target | gene | 1.00 |
| Carcinoma | associated_with | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Aging | therapeutic_target | disease | 1.00 |
| Apoptosis | therapeutic_target | pathway | 1.00 |
| Cancer | expressed_in | disease | 1.00 |
| Tumor | expressed_in | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| Als | inhibits | disease | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| GENES | associated_with | gene | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| GENES | regulates | gene | 1.00 |
| Tumor | regulates | disease | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| Als | activates | disease | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| CANCER | inhibits | gene | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| P53 | inhibits | gene | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| OXIDATIVE STRESS | associated_with | gene | 1.00 |
| P53 | regulates | gene | 1.00 |
| P53 | expressed_in | gene | 1.00 |
| CANCER | expressed_in | gene | 1.00 |
| DNA | activates | gene | 1.00 |
| GENES | activates | gene | 1.00 |
| CANCER | treats | gene | 1.00 |
| Cancer | treats | disease | 1.00 |
| Als | treats | disease | 1.00 |
| Immunotherapy | therapeutic_target | pathway | 1.00 |
| DNA | implicated_in | gene | 1.00 |
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| EGFR | associated_with | gene | 1.00 |
| ESR1 | therapeutic_target | gene | 1.00 |
| GENES | inhibits | gene | 1.00 |
| DNA | therapeutic_target | gene | 1.00 |
| Pi3K/Akt | therapeutic_target | pathway | 1.00 |
| DNA | associated_with | gene | 1.00 |
| BCL2 | interacts_with | protein | 1.00 |
| Apoptotic Cell Death | mediates | process | 0.95 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MTOR | associated_with | gene | 1.00 |
| PI3K | therapeutic_target | gene | 1.00 |
| TNF | therapeutic_target | gene | 1.00 |
| PI3K | associated_with | gene | 1.00 |
| AKT | associated_with | gene | 1.00 |
| AKT1 | therapeutic_target | gene | 1.00 |
| APOPTOSIS | associated_with | gene | 1.00 |
| KRAS | associated_with | gene | 1.00 |
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| PARKINSON'S DISEASE | associated_with | gene | 0.98 |
| IRP2 | regulates | protein | 0.95 |
| IRP2 | post_transcriptionally_upregulates | protein | 0.95 |
| Emodin | binds_to | drug | 0.95 |
| ASPP1 | interacts_with | protein | 0.95 |
| USP36 | inhibits | enzyme | 0.95 |
| DRAGO | interacts_with | gene | 0.95 |
| POLY(PROLINE-ARGININE) | activates | protein | 0.92 |
| MDM2 | inhibits | protein | 0.92 |
| SRT2104 | downregulates | drug | 0.92 |
| Emodin | inhibits | drug | 0.90 |
| ASPP1 | regulates | protein | 0.90 |
| FMDV VP3 protein | modulates | protein | 0.90 |
| PC14586 | binds_to | drug | 0.90 |
| PC14586 | activates | drug | 0.90 |
| RBM28 | binds | protein | 0.90 |
| RBM28 | suppresses | protein | 0.90 |
| FBL | activates | gene | 0.90 |
| MDM2 | interacts_with | gene | 0.90 |
| KIAA0247 | interacts_with | gene | 0.90 |
| NEURON | activates | cell_type | 0.90 |
| MAPK1 | interacts_with | protein | 0.89 |
| TNF | activates | entity | 0.88 |
| CHRYSOTIXINE | activates | compound | 0.88 |
| MT2 | regulates | protein | 0.85 |
| ALOX12 | mediates | entity | 0.85 |
| NFKB1 | regulates | protein | 0.85 |
| XPO1 | reduces | protein | 0.85 |
| Polygonatum Sibiricum Polysaccharide | downregulates | compound | 0.85 |
| Xiyangshen Sanqi Danshen Granules | downregulates | drug | 0.85 |
| SIRT1 | downregulates | protein | 0.85 |
| ACTG1 | binds | protein | 0.85 |
| PMIγ | inhibits | compound | 0.85 |
| ALKBH5 | associated_with | entity | 0.85 |
| BPA | binds_to | drug | 0.85 |
| KIAA0247 | associated_with | gene | 0.85 |
| NRF2 | associated_with | gene | 0.82 |
| AUTOPHAGY | associated_with | gene | 0.82 |
| CHEK2 | interacts_with | gene | 0.80 |
| AGGF1 | stabilizes | gene | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||