entity

Cort

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Cort: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections
9Hypotheses
9Analyses
0Outgoing
1Incoming

Wiki Pages (20)

Knowledge base pages for this entity

calcium-dysregulation-comparison

mechanism · 6468 words

CORT108297 Phase 2 (NCT04601038) - Stress Attenuation in AD

clinical · 3284 words

Urolithin A for Neurodegeneration

therapeutic · 3258 words

KCNK18 — Potassium Two Pore Domain Channel Subfamily K Member 18 (TRESK)

gene · 2933 words

AI-Powered Diagnostics for Alzheimer's Disease

technology · 2356 words

Outgoing (0)

TargetRelationTypeStr
No outgoing edges

Incoming (2)

SourceRelationTypeStr
Alopecia Areatabiomarker_fordisease0.85

Targeting Hypotheses (9)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Closed-loop transcranial focused ultrasound with 40Hz gamma 0.689 Alzheimer's disease Circuit-level neural dynamics in neurode
Gamma entrainment therapy to restore hippocampal-cortical sy 0.681 Alzheimer's disease Circuit-level neural dynamics in neurode
Closed-loop tACS targeting entorhinal cortex layer II SST in 0.625 Alzheimer's disease Circuit-level neural dynamics in neurode
Alpha-gamma cross-frequency coupling enhancement to restore 0.621 Alzheimer's disease Circuit-level neural dynamics in neurode
Interneuron SYNGAP1 Deficiency Disrupts Cortical Circuit Ass 0.576 neurodevelopment How does SYNGAP1, a 'synaptic' protein,
GluN2B-Mediated Thalamocortical Control of Glymphatic Tau Cl 0.575 neuroscience Circuit-level neural dynamics in neurode
Thalamocortical Synchrony Restoration via NMDA Modulation 0.542 neuroscience Circuit-level neural dynamics in neurode
Cortico-Striatal Synchrony Restoration via NMDA Modulation 0.500 neuroscience Circuit-level neural dynamics in neurode
Complement C1QA Spatial Gradient in Cortical Layers 0.428 Alzheimer's Disease SEA-AD Gene Expression Profiling — Allen

Mentioning Analyses (9)

Scientific analyses that reference this entity

How does SYNGAP1, a 'synaptic' protein, function in pre-synaptic radial glia cel

neurodevelopment | 2026-04-15 | 1 hypotheses Top: 0.576

Why does autophagy inhibition improve neuronal survival when autophagy is typica

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.557

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

neurodegeneration | 2026-04-13 | 0 hypotheses

Human connectome alterations and network-level dysfunction in Alzheimer disease

neurodegeneration | 2026-04-04 | 0 hypotheses

Circuit-level neural dynamics in neurodegeneration

neuroscience | 2026-04-03 | 49 hypotheses Top: 0.709

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Perivascular cells induce microglial phagocytic states and synaptic engulfment v [PMID:36747024] De Schepper S, Ge JZ, Sierksma A, Crowle Nat Neurosci 2023 2
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614] Han QQ, Shen SY, Liang LF, Chen XR, Yu J Brain Behav Immun 2024 1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704] Zhang T, Xu D, Trefts E, Lv M, Inuzuka H Science 2023 1
Anatomical and neurochemical profiles of somatostatin-positive neurons in the mo [PMID:41796787] Tomioka R, Kobayashi K, Song WJ Neuroscience 2026 0
Subtype-Specific Roles of Anterior Cingulate Cortex Neurons in Pain-Induced Soci [PMID:41799202] Wan X, Yan Z, Zhang Z, Liu X, Yang D, Zh Theranostics 2026 0
A comparative analysis of pig-to-rhesus corneal xenotransplantation with various [PMID:41928466] Lee SH, Yoon CH, Choi HJ, Lee HJ, Kang H Korean J Ophthalmol 2026 0
External fixation versus reverse shoulder arthroplasty for proximal humerus frac [PMID:41940987] Vadalà A, Benelli C, Suraci F, Carta B, Arch Orthop Trauma Surg 2026 0
Epigenetically regulated pancreatic GABA-somatostatin signaling underlies gestat [PMID:41779871] Zhu H, Luo S, Liu C, Cheng Y, Ren Z, Mo Science translational medicine 2026 0
Therapeutic Potential of Somatostatin and Its Analogues in Alzheimer's Disease: [PMID:41854733] Liu K, Zhang XY, Wang YT, Wang R, Jin RH Molecular neurobiology 2026 0
Altered Expression of GABA-Related Genes in Schizophrenia: Insights from Meta-An [PMID:41788138] Singer Y, Yitzhaky A, Hertzberg L Alpha psychiatry 2026 0
Paracrine inhibition via G protein inwardly rectifying potassium channels regula [PMID:41824458] Panzer JK, Lang AL, Levi NJ, Garcia PA, Cell reports 2026 0
Inspired by molecular dynamic simulation, exploring chemical constituents of alc [PMID:40166865] Shinge J, Muthal A, Walhekar V, Bagul C, Journal of biomolecular struct 2026 0
Cognitive loss after brain trauma results from sex-specific activation of synapt [PMID:40796363] Arizanovska D, Bush GF, Dallera CA, Folo Brain 2026 0
Inhibition of GluN2B-containing N-methyl-D-aspartate receptors by radiprodil. [PMID:40994429] Banke TG, Regan MC, Perszyk RE, Zhang L, Brain 2026 0
GluN2B-specific NMDAR positive allosteric modulation reverses cognitive and beha [PMID:41512078] Ge Y, Tian T, Li B, Axerio-Cillies P, Ch Sci Adv 2026 0
Zipper-interacting Protein Kinase Modulates Gene Expression Linked to Synaptic a [PMID:41526727] Mei Y, Zheng L, He M, Wang L, Zhou Y et Mol Neurobiol 2026 0
Multi-biofluid metabolomics coupled with gene network reveals stage-specific alt [PMID:41534821] Cadaxo AS, Cotrin JC, Valente AP, Lopes Brain Res 2026 0
Aberrant mRNA splicing and impaired hippocampal neurogenesis in Grin2b mutant mi [PMID:41675057] Farsi Z, Nicolella A, Simmons SK, Shin W iScience 2026 0
From synapse to system: mechanistic pathways of neural signaling dysfunction in [PMID:41799440] Gupta R, Jha NK, Kumar N, Nagraik R, Rav Front Cell Dev Biol 2026 0
Cellular Prion Protein Engages the N-Methyl-d-Aspartate Receptor through N- and [PMID:41860118] Mayfield JE, Wang J, Tovell H, Taylor SS Biochemistry 2026 0