gene

DCLRE1A

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about DCLRE1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

DCLRE1A (DNA Cross-Link Repair 1A) encodes a nuclease involved in DNA interstrand crosslink repair, crucial for genomic stability in post-mitotic neurons

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🧬 Gene Info

Gene Symbol	DCLRE1A
Full Name	DNA Cross-Link Repair 1A
Chromosome	10q26.3
Function	encodes a member of the metallo-beta-lactamase superfamily of nucleases involved in DNA repair.
Primary Expression	Ubiquitous, high in brain
UniProt ID	[Q9H9Y6](https://www.uniprot.org/uniprotkb/Q9H9Y6/entry)
GeneCards	DCLRE1A
Human Protein Atlas	DCLRE1A
ICL unhooking	Cleaves the DNA on one side of the crosslink, releasing one strand for translesion synthesis
Strand resection	Generates 3' overhangs that facilitate homologous recombination
Drafting	Removes blocking nucleotides during DNA repair synthesis
Associated Diseases	Alzheimer's disease, Parkinson's disease
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DCLRE1A Gene

gene · 1632 words

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Pathway Diagram

graph TD
    DCLRE1A["DCLRE1A"]
    neurodegeneration["neurodegeneration"]
    DCLRE1A -->|"implicated_in"| neurodegeneration
    style DCLRE1A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning DCLRE1A in their description or question text

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