gene

DDX60

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DDX60: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

9Outgoing

1Incoming

0Experiments

0Debates

Summary

DDX60 — DEAD-Box Helicase 60

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🧬 Gene Info

Gene Symbol	DDX60
Full Name	DEAD-Box Helicase 60
Chromosome	4q33
Function	is an RNA helicase involved in antiviral immunity and RNA metabolism.
GeneCards	DDX60
Human Protein Atlas	DDX60
DEAD Box Core	The central helicase domain containing the conserved motifs (Q-motif, motifs I-VI) responsible for ATP hydrolysis and RNA unwinding [@fairmanwilliams2010]
LRR Domain	Leucine-rich repeat region at the N-terminus, potentially involved in protein-protein interactions and RNA binding [@moy2009]
C-terminal Domain	Involved in substrate specificity and interaction with signaling partners
Associated Diseases	neurodegeneration
Interactions	AKT, IFN, KRAS, RNA, STAT3
KG Connections	10 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DDX60 — DEAD-Box Helicase 60

gene · 983 words

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Pathway Diagram

flowchart TD
    N0["DDX60"]
    N1["AKT"]
    N1 -->|"inhibits"| N0
    N2["IFN"]
    N0 -->|"regulates"| N2
    N3["KRAS"]
    N0 -->|"regulates"| N3
    N4["STAT3"]
    N0 -->|"inhibits"| N4
    N5["Wnt signaling"]
    N0 -->|"participates in"| N5
    N6["RNA"]
    N0 -->|"regulates"| N6

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    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
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    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
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    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
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    class N0 gene
    class N1 gene
    class N2 gene
    class N3 gene
    class N4 gene
    class N5 pathway
    class N6 gene

Outgoing (9)

Target	Relation	Type	Str
IFN	regulates	gene	0.60
KRAS	regulates	gene	0.60
KRAS	activates	gene	0.60
IFN	activates	gene	0.60
KRAS	inhibits	gene	0.60
Wnt signaling	participates_in	pathway	0.60
RNA	regulates	gene	0.60
RNA	activates	gene	0.60
STAT3	inhibits	gene	0.60

Incoming (1)

Source	Relation	Type	Str
AKT	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DDX60 in their description or question text

No additional research found