Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DRD3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | DRD3 |
| Full Name | Dopamine Receptor D3 |
| Chromosome | 3q13.31 |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | the limbic system and plays critical roles in reward, motivation, and movement control |
| Molecular Weight | 130 kDa |
| Pathways | MAPK, PI3K |
| UniProt ID | P35462 |
| NCBI Gene ID | 1818 |
| Ensembl ID | ENSG00000151577 |
| OMIM | 139251 |
| GeneCards | DRD3 |
| Human Protein Atlas | DRD3 |
| Protein Class | G Protein-Coupled Receptor (Class A) |
| Associated Diseases | neurodegeneration |
| Known Drugs/Compounds | D-520 |
| Interactions | ULK1, DRD2, AMPK |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
DRD3["DRD3"]
Berberine_Inspired_Ionizable_Lipid["Berberine-Inspired Ionizable Lipid"]
Blood_Brain_Barrier_Penetration["Blood-Brain Barrier Penetration"]
D_520{"D-520"}
neurodegeneration["neurodegeneration"]
DRD3 -->|"mediates"| Berberine_Inspired_Ionizable_Lipid
DRD3 -->|"mediates"| Blood_Brain_Barrier_Penetration
D_520 -->|"activates"| DRD3
DRD3 -->|"implicated in"| neurodegeneration
style DRD3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
style Berberine_Inspired_Ionizable_Lipid fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff
style Blood_Brain_Barrier_Penetration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff
style D_520 fill:#1a3a3a,stroke:#4dd0e1,stroke-width:2px,color:#fff
style neurodegeneration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| ULK1 | activates | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.55 |
| benchmark_ot_ad_answer_key:DRD3 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| D-520 | binds | drug | 0.90 |
| DRD2 | activates | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| benchmark_ot_ad_answer_key:DRD3 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||